A simplified function-first method for the discovery and optimization of bispecific immune engaging antibodies

Autor: Alex Shepherd, Bigitha Bennychen, Anne Marcil, Darin Bloemberg, Robert A. Pon, Risini D. Weeratna, Scott McComb

Publikováno v: PLoS ONE, Vol 18, Iss 6 (2023)

Bi-specific T-cell engager antibodies (BiTEs) are synthetic fusion molecules that combine multiple antibody-binding domains to induce active contact between T-cells and antigen expressing cells in the body. Blinatumomab, a CD19-CD3 BiTE is now a wide

Externí odkaz: https://doaj.org/article/b963816902bb40d5ba44061d2e1b1911

A High-Throughput Method for Characterizing Novel Chimeric Antigen Receptors in Jurkat Cells

Autor: Darin Bloemberg, Tina Nguyen, Susanne MacLean, Ahmed Zafer, Christine Gadoury, Komal Gurnani, Anindita Chattopadhyay, Josée Ash, Julie Lippens, Doreen Harcus, Martine Pagé, Annie Fortin, Robert A. Pon, Rénald Gilbert, Anne Marcil, Risini D. Weeratna, Scott McComb

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 16, Iss , Pp 238-254 (2020)

Chimeric antigen receptor (CAR) development involves extensive empirical characterization of antigen-binding domain (ABD)/CAR constructs for clinical suitability. Here, we present a cost-efficient and rapid method for evaluating CARs in human Jurkat

Externí odkaz: https://doaj.org/article/b53d7d3e370f450b9900f99abd4d6663

Mechanism of γδ T cell-induced human oligodendrocyte cytotoxicity: relevance to multiple sclerosis

Autor: Rana Zeine, Mark S. Freedman, Jack P. Antel, Robert A. Pon, Uma Ladiwala, Lionel G. Filion

Publikováno v: Journal of Neuroimmunology. 87:49-61

Gammadelta T cells may contribute to the pathogenesis of Multiple Sclerosis (MS) via cytotoxicity directed at the myelin-oligodendrocyte unit. We have previously demonstrated that peripheral blood-derived gammadelta T cells lyse fresh human oligodend

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e7bec5c2222be68ae11cd707d04ff4
https://doi.org/10.1016/s0165-5728(98)00047-2

List of Contributors

Autor: Nawaf Al-Maharik, Heidi Annuk, Michael A. Apicella, Ben J. Appelmelk, Ivo G. Boneca, Petra Born, Klaus Brandenburg, Patrick J. Brennan, Volker Briken, Eric D. Brown, Stephen D. Carrington, Paola Cescutti, Delphi Chatterjee, Marguerite Clyne, Richard M. Cooper, Anthony P. Corfield, Monica M. Cunneen, Piet W.J. de Groot, Gennaro De Libero, Clara G. de los Reyes-Gavilán, Tamara L. Doering, Max Dow, Nicole N. Driessen, Jeffrey C. Dyason, Eva Maria Egelseer, Alan D. Elbein, Mario F. Feldman, Eamonn Fitz Patrick, Yukari Fujimoto, Koichi Fukase, Patrick Garidel, Jeroen Geurtsen, Marlyn Gonzalez, I. Darren Grice, Patricia Guerry, Thomas Gutsmann, Holger Heine, Joanne Heng, Otto Holst, Harold. J Jennings, Michael P. Jennings, Margaret I. Kanipes, Dennis L. Kasper, Wafa Khamri, Milton J. Kiefel, Dionne C.G. Klein, Frans M. Klis, Yuriy A. Knirel, Thomas Kohler, Paul Kosma, Emir Kulauzovic, Shoichi Kusumoto, John R. Lawrence, Clifford A. Lingwood, Peter N. Lipke, Susan M. Logan, Radia Mahfoud, Malcolm J. McConville, Rachel M. McLoughlin, Paul Messner, Antonio Molinaro, Anthony P. Moran, Thomas Naderer, Thomas R. Neu, Mari-Anne Newman, Andrei V. Nikolaev, Christian M. Pedersen, Mark P. Pereira, Andreas Peschel, Stefan Pöhlmann, Robert A. Pon, Stuart A. Ralph, Peter R. Reeves, Anne N. Reid, Colm J. Reid, Morgann C. Reilly, Sabine Riekenberg, Patricia Ruas-Madiedo, Nuria Salazar, Christina Schäffer, Richard R. Schmidt, Ian C. Schoenhofen, Marit Sletmoen, Uwe B. Sleytr, Evelyn C. Soo, Imke Steffen, Daniel C. Stein, Bjørn T. Stokke, Christine M. Szymanski, Joe Tiralongo, Jennifer A. Tee, Mark R. Thursz, M. Stephen Trent, Theodros S. Tsegaye, Jean van Heijenoort, Waldemar Vollmer, Mark von Itzstein, Jennifer C. Wilson, Guoqing Xia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f309f19d53c57b2a7fee9813b303d0ea
https://doi.org/10.1016/b978-0-12-374546-0.00053-5

[24] Induction of rabbit immunoglobulin G antibodies against synthetic sialylated neoglycoproteins

Autor: Andrzej Gamian, Craig A. Laferrière, René Roy, Robert A. Pon

Publisher Summary This chapter illustrates that the prime event in influenza virus infections depends on the recognition and discusses the binding of the viral glycoprotein hemagglutinin to the cell surface sialic acids. As multivalencies have been r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c399e91704bdf286485e276d11077916
https://doi.org/10.1016/s0076-6879(94)47026-x