Zobrazeno 1 - 10
of 259
pro vyhledávání: '"Robert A. Pearce"'
Autor:
Thomas Payne, Jennifer Taylor, David Kunkel, Katherine Konieczka, Frankie Ingram, Kaj Blennow, Henrik Zetterberg, Robert A. Pearce, Anke Meyer-Franke, Niccolò Terrando, Katerina Akassoglou, Robert D. Sanders, Richard C. Lennertz
Publikováno v:
BJA Open, Vol 12, Iss , Pp 100349- (2024)
Background: We aimed to assess perioperative changes in fibrinogen in the cerebrospinal fluid (CSF), their association with markers of blood–brain barrier breakdown and neuroinflammation, and their association with postoperative delirium severity.
Externí odkaz:
https://doaj.org/article/46f97a63a6754a3c850420900105059e
Autor:
Cameron P. Casey, Sean Tanabe, Zahra Farahbakhsh, Margaret Parker, Amber Bo, Marissa White, Tyler Ballweg, Andrew Mcintosh, William Filbey, Matthew I. Banks, Yuri B. Saalmann, Robert A. Pearce, Robert D. Sanders
Publikováno v:
NeuroImage, Vol 263, Iss , Pp 119657- (2022)
The neural mechanisms through which individuals lose sensory awareness of their environment during anesthesia remains poorly understood despite being of vital importance to the field. Prior research has not distinguished between sensory awareness of
Externí odkaz:
https://doaj.org/article/ac6cffde462245fd832192982a0cd81e
Autor:
David Kunkel, Margaret Parker, Cameron Casey, Bryan Krause, Jennifer Taylor, Robert A. Pearce, Richard Lennertz, Robert D. Sanders
Publikováno v:
BJA Open, Vol 2, Iss , Pp 100006- (2022)
Background: Perioperative inflammation is associated with perioperative complications, including delirium, that are associated with a reduced number of postoperative days alive and at home at 90 days (DAH90). We tested whether inflammation was associ
Externí odkaz:
https://doaj.org/article/49c4e74195864577ae5b73a79117fc6d
Autor:
Alifayaz Abdulzahir, Steven Klein, Chong Lor, Mark G. Perkins, Alyssa Frelka, Robert A. Pearce
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5637 (2023)
Point mutations in the β2 (N265S) and β3 (N265M) subunits of γ-amino butyric acid type A receptors (GABAARs) that render them insensitive to the general anesthetics etomidate and propofol have been used to link modulation of β2-GABAARs to sedatio
Externí odkaz:
https://doaj.org/article/5b6c594b434a40b6882f24508751a985
Autor:
David A. Ruhl, Ewa Bomba-Warczak, Emma T. Watson, Mazdak M. Bradberry, Tabitha A. Peterson, Trina Basu, Alyssa Frelka, Chantell S. Evans, Joseph S. Briguglio, Tamara Basta, Michael H. B. Stowell, Jeffrey N. Savas, Avtar Roopra, Robert A. Pearce, Robert C. Piper, Edwin R. Chapman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The functional role of synaptotagmin-17 (syt-17) has remained unanswered. In this study, authors demonstrate that syt-17 exists in two distinct pools in hippocampal neurons (Golgi complex and early endosomes), where it served two completely independe
Externí odkaz:
https://doaj.org/article/2285b841eadf401cae3e662ea7ba2f42
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 24, p 9534 (2020)
Background: Mice carrying the GABAA receptor β3(N265M) point mutation, which renders receptors incorporating β3-subunits insensitive to many general anesthetics, have been used experimentally to link modulation of different receptor subtypes to dis
Externí odkaz:
https://doaj.org/article/ca7d2cd45fcd42708aa0df81787f29f3
Autor:
Thomas Payne, Jennifer Taylor, Cameron Casey, David Kunkel, Maggie Parker, Kaj Blennow, Henrik Zetterberg, Robert A. Pearce, Richard C. Lennertz, Robert D. Sanders
Publikováno v:
British Journal of Anaesthesia. 130:546-556
Autor:
Jennifer Taylor, Laura Eisenmenger, Heidi Lindroth, James Booth, Rosaleena Mohanty, Veena Nair, Margaret Parker, David Kunkel, Cameron Rivera, Cameron Casey, Henrik Zetterberg, Kaj Blennow, Marko Mrkobrada, Philip J. Devereaux, Robert A. Pearce, Richard Lennertz, Vivek Prabhakaran, Robert D. Sanders
Publikováno v:
British Journal of Anaesthesia. 130:e361-e369
Ischaemic brain infarction can occur without acute neurological symptoms (covert strokes) or with symptoms (overt strokes), both associated with poor health outcomes. We conducted a pilot study of the incidence of preoperative and postoperative (intr
Publikováno v:
British Journal of Anaesthesia. 130:e449-e451
Autor:
Sean Tanabe, Maggie Parker, Richard Lennertz, Robert A Pearce, Matthew I Banks, Robert D Sanders
Publikováno v:
The journals of gerontology. Series A, Biological sciences and medical sciences. 77(11)