Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Robert A. Ortmann"'
Autor:
Iain B. McInnes, Nicole L. Byers, Richard E. Higgs, Jonathan Lee, William L. Macias, Songqing Na, Robert A. Ortmann, Guilherme Rocha, Terence P. Rooney, Thomas Wehrman, Xin Zhang, Steven H. Zuckerman, Peter C. Taylor
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-10 (2019)
Abstract Background The in vitro pharmacology of baricitinib, upadacitinib, and tofacitinib was evaluated to understand differences among these JAK inhibitors (JAKis) at the cellular level. Methods Peripheral blood mononuclear cells from healthy dono
Externí odkaz:
https://doaj.org/article/9199674c675b4aa38a99899ed7156b79
Autor:
Désirée van der Heijde, Yoshiya Tanaka, Paul Emery, Li Xie, Michael Schiff, Gabriella Meszaros, Taeko Ishii, Marta Casillas, Robert A Ortmann
Publikováno v:
RMD Open, Vol 5, Iss 1 (2019)
Objectives To evaluate radiographic progression of structural joint damage over 2 years in patients with rheumatoid arthritis from baricitinib clinical trials who were disease-modifying antirheumatic drug (DMARD)–naïve or had an inadequate respons
Externí odkaz:
https://doaj.org/article/be6b2b26b8de45dd8bafd2d67de4083f
Fibroblast-like synoviocytes (FLS) are major effector cells in Rheumatoid arthritis (RA). Toll-like receptor-2 (TLR2) activation of FLS plays a key role in RA pathogenesis. Recently, statins have been shown to modulate RA. We investigated the immunom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93d3c93705bd7450a89e20b26dff95d4
https://doi.org/10.1101/2022.05.30.493863
https://doi.org/10.1101/2022.05.30.493863
Autor:
Melvin R. Hayden, Javad Habibi, Nazif A. Chowdhury, Poorna Rajasekhar Karuparthi, Gurushankar Govindarajan, Robert A. Ortmann
Publikováno v:
Journal of the CardioMetabolic Syndrome. 1:228-232
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e43222623bb4bca739ca8ce8d355f00
https://doi.org/10.1111/j.1559-4564.2006.05817.x
https://doi.org/10.1111/j.1559-4564.2006.05817.x
Publikováno v:
Pathophysiology. 12:167-181
Rodent models of rheumatoid arthritis (RA) are useful tools to study the pathogenic process of RA. Among the most widely used models of RA are the streptococcal cell wall (SCW) arthritis model and the collagen-induced arthritis (CIA). Both innate and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::729763df8073d7bf548f0b9618692691
https://doi.org/10.1016/j.pathophys.2005.07.011
https://doi.org/10.1016/j.pathophys.2005.07.011
Autor:
Eric L. Greidinger, Robert A. Ortmann, Rebecca L. Jorgenson, Michael L. Misfeldt, Mark F. Foecking, Tal Gazitt, Steven L. Young, Robert W. Hoffman
Publikováno v:
Arthritis & Rheumatism. 50:2891-2896
The U1-70-kd RNP is a prominent target of autoimmunity in connective tissue diseases. In this study, we explored whether its endogenous ligand, U1 RNA, mediates a proimmune signal and may be immunogenic.We assayed the proliferation of control and MyD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9143a9b6fc767e5a450beba580e83343
https://doi.org/10.1002/art.20428
https://doi.org/10.1002/art.20428
Publikováno v:
The Journal of Immunology. 166:5712-5719
B10.Q mice are normally susceptible to the induction of collagen-induced arthritis. We noted that one subline of B10.Q mice, B10.Q/J, was completely resistant to disease induction when immunized with collagen in CFA. B10.Q/J mice have a global defect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b3df45ba25690407d60b58ef0c9016
https://doi.org/10.4049/jimmunol.166.9.5712
https://doi.org/10.4049/jimmunol.166.9.5712
Autor:
Robert A. Ortmann, John H. Klippel
Publikováno v:
Rheumatic Disease Clinics of North America. 26:363-375
Over the past decade cyclophosphamide has come to assume an increasingly prominent role in the management of severe, life-threatening manifestations of SLE. Intermittent, intravenous pulse cyclophosphamide has become the standard of treatment of diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422b93c153dda593f2c9048a012bf073
https://doi.org/10.1016/s0889-857x(05)70143-5
https://doi.org/10.1016/s0889-857x(05)70143-5
Autor:
Beixue Gao, Robert A. Ortmann, Deyu Fang, Krishnaswamy Kannan, Sang-Myeong Lee, An Chen, Jinping Zhang, Donna D. Zhang
The E3 ubiquitin ligase synoviolin (SYVN1) functions as an anti-apoptotic factor that is responsible for the outgrowth of synovial cells during the development of rheumatoid arthritis. The molecular mechanisms underlying SYVN1 regulation of cell deat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dbe2d0a114d63691ef22a307c4439a3
https://europepmc.org/articles/PMC2373369/
https://europepmc.org/articles/PMC2373369/
Publikováno v:
The FASEB Journal. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a213ead7dd3bcee52cb47aa7af6c049
https://doi.org/10.1096/fasebj.22.1_supplement.675.21
https://doi.org/10.1096/fasebj.22.1_supplement.675.21