Zobrazeno 1 - 10
of 501
pro vyhledávání: '"Robert A. O'rourke"'
Autor:
Alexander Ky, Atticus J. McCoy, Carmen G. Flesher, Nicole E. Friend, Jie Li, Kore Akinleye, Christopher Patsalis, Carey N. Lumeng, Andrew J. Putnam, Robert W. O’Rourke
Publikováno v:
Adipocyte, Vol 12, Iss 1 (2023)
ABSTRACTAlterations of the extracellular matrix contribute to adipose tissue dysfunction in metabolic disease. We studied the role of matrix density in regulating human adipocyte phenotype in a tunable hydrogel culture system. Lipid accumulation was
Externí odkaz:
https://doaj.org/article/849bf78638d543b0b0b52a41d2e819ae
Autor:
Qianqian Kang, Xiaorong Zhu, Decheng Ren, Alexander Ky, Ormond A. MacDougald, Robert W. O'Rourke, Liangyou Rui
Publikováno v:
Advanced Science, Vol 10, Iss 28, Pp n/a-n/a (2023)
Abstract White adipose tissue (WAT) lipolysis releases free fatty acids as a key energy substance to support metabolism in fasting, cold exposure, and exercise. Atgl, in concert with Cgi‐58, catalyzes the first lipolytic reaction. The sympathetic n
Externí odkaz:
https://doaj.org/article/423e17ecec094af0a0625656f8719ffa
Autor:
Strieder-Barboza, Carmen G. Flesher, Lynn M. Geletka, Tad Eichler, Olukemi Akinleye, Alexander Ky, Anne P. Ehlers, Carey N. Lumeng, Robert W. O’Rourke
Publikováno v:
Adipocyte, Vol 11, Iss 1, Pp 665-675 (2022)
ABSTRACTObesity-associated type 2 diabetes (DM) leads to adipose tissue dysfunction. Lumican is a proteoglycan implicated in obesity, insulin resistance (IR), and adipocyte dysfunction. Using human visceral adipose tissue (VAT) from subjects with and
Externí odkaz:
https://doaj.org/article/bfc5b3bfcf8747499aca7f06d5b0c508
Autor:
Nicholas J. Carruthers, Clarissa Strieder-Barboza, Joseph A. Caruso, Carmen G. Flesher, Nicki A. Baker, Samuel A. Kerk, Alexander Ky, Anne P. Ehlers, Oliver A. Varban, Costas A. Lyssiotis, Carey N. Lumeng, Paul M. Stemmer, Robert W. O’Rourke
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Dysfunctional visceral adipose tissue (VAT) in obesity is associated with type 2 diabetes (DM) but underlying mechanisms remain unclear. Our objective in this discovery analysis was to identify genes and proteins regulated by DM to elucidate
Externí odkaz:
https://doaj.org/article/024c6a60909c4763a385cab961c87175
Autor:
J. K. Wenderott, Carmen G. Flesher, Nicki A. Baker, Christopher K. Neeley, Oliver A. Varban, Carey N. Lumeng, Lutfiyya N. Muhammad, Chen Yeh, Peter F. Green, Robert W. O’Rourke
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Abstract Obesity-related type 2 diabetes (DM) is a major public health concern. Adipose tissue metabolic dysfunction, including fibrosis, plays a central role in DM pathogenesis. Obesity is associated with changes in adipose tissue extracellular matr
Externí odkaz:
https://doaj.org/article/7d43f4f971fb465e90cbeab3655e3e1f
Autor:
Clarissa Strieder-Barboza, Nicki A. Baker, Carmen G. Flesher, Monita Karmakar, Ayush Patel, Carey N. Lumeng, Robert W. O’Rourke
Publikováno v:
Adipocyte, Vol 9, Iss 1, Pp 189-196 (2020)
Subcutaneous (SAT) and visceral (VAT) adipose tissues have distinct metabolic phenotypes. We hypothesized that the extracellular matrix (ECM) regulates depot-specific differences in adipocyte metabolic function in murine obesity. VAT and SAT preadipo
Externí odkaz:
https://doaj.org/article/0970a11f195b4b1d81be62a7cd31e02a
Autor:
Lindsey A. Muir, Kae Won Cho, Lynn M. Geletka, Nicki A. Baker, Carmen G. Flesher, Anne P. Ehlers, Niko Kaciroti, Stephen Lindsly, Scott Ronquist, Indika Rajapakse, Robert W. O’Rourke, Carey N. Lumeng
Publikováno v:
JCI Insight, Vol 7, Iss 3 (2022)
Increased adipose tissue macrophages (ATMs) correlate with metabolic dysfunction in humans and are causal in development of insulin resistance in mice. Recent bulk and single-cell transcriptomics studies reveal a wide spectrum of gene expression sign
Externí odkaz:
https://doaj.org/article/e2a3aa6ca7054fe5b756515764982b7c
Autor:
Clarissa Strieder-Barboza, Carmen G. Flesher, Lynn M. Geletka, Tad Eichler, Olukemi Akinleye, Alexander Ky, Anne P. Ehlers, Carey N. Lumeng, Robert W. O’Rourke
Publikováno v:
Adipocyte. 11:665-675
Obesity-associated type 2 diabetes (DM) leads to adipose tissue dysfunction. Lumican is a proteoglycan implicated in obesity, insulin resistance (IR), and adipocyte dysfunction. Using human visceral adipose tissue (VAT) from subjects with and without
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0f4d84ed0a529af662af5800ba54ee
https://doi.org/10.1080/21623945.2022.2154112
https://doi.org/10.1080/21623945.2022.2154112
Autor:
Henriette Frikke-Schmidt, Brian F. Zamarron, Robert W. O'Rourke, Darleen A. Sandoval, Carey N. Lumeng, Randy J. Seeley
Publikováno v:
Molecular Metabolism, Vol 6, Iss 4, Pp 317-326 (2017)
Objective: In addition to adipocytes, adipose tissue contains large numbers of immune cells. A wide range of evidence links the activity of these cells to regulation of adipocyte and systemic metabolic function. Bariatric surgery improves several asp
Externí odkaz:
https://doaj.org/article/5aa7cb83e36144418370d3a91937ea8d
Autor:
Robert W. O'Rourke, Girish Gandikota, Shadi F. Azar, David A. Jamadar, Ashish P. Wasnik, Elaine M. Caoili
Publikováno v:
Clinical Imaging. 74:131-138
Objective Spigelian hernia is an uncommon congenital or acquired defect in the transversus abdominis aponeurosis with non-specific symptoms posing a diagnostic challenge. There is a paucity of radiology literature on imaging findings of Spigelian her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13daec716f8a07ab04a3c040d5524f88
https://doi.org/10.1016/j.clinimag.2020.12.031
https://doi.org/10.1016/j.clinimag.2020.12.031