Zobrazeno 1 - 10
of 344
pro vyhledávání: '"Robert A. Menzies"'
Autor:
Josselin Nespoux, Marie-Louise T. Monaghan, Natalie K. Jones, Kevin Stewart, Laura Denby, Alicja Czopek, John J. Mullins, Robert I. Menzies, Andrew H. Baker, Matthew A. Bailey
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract P2X7 receptors mediate immune and endothelial cell responses to extracellular ATP. Acute pharmacological blockade increases renal blood flow and filtration rate, suggesting that receptor activation promotes tonic vasoconstriction. P2X7 expre
Externí odkaz:
https://doaj.org/article/3754b0ae722445b28dc0fc7b7de55dfa
Autor:
Zaher ElBeck, Mohammad Bakhtiar Hossain, Humam Siga, Nikolay Oskolkov, Fredrik Karlsson, Julia Lindgren, Anna Walentinsson, Dominique Koppenhöfer, Rebecca Jarvis, Roland Bürli, Tanguy Jamier, Elske Franssen, Mike Firth, Andrea Degasperi, Claus Bendtsen, Robert I. Menzies, Katrin Streckfuss-Bömeke, Michael Kohlhaas, Alexander G. Nickel, Lars H. Lund, Christoph Maack, Ákos Végvári, Christer Betsholtz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract While excessive production of reactive oxygen species (ROS) is a characteristic hallmark of numerous diseases, clinical approaches that ameliorate oxidative stress have been unsuccessful. Here, utilizing multi-omics, we demonstrate that in c
Externí odkaz:
https://doaj.org/article/8cb734f3e6db454ca663dbe7df2cc0bb
Autor:
Bijan Najafi, James S. Wrobel, Gurtej Grewal, Robert A. Menzies, Talal K. Talal, Mahmoud Zirie, David G. Armstrong
Publikováno v:
Journal of Aging Research, Vol 2012 (2012)
Objective. Asymmetric plantar temperature differences secondary to inflammation is a hallmark for the diagnosis and treatment response of Charcot foot syndrome. However, little attention has been given to temperature response to activity. We examined
Externí odkaz:
https://doaj.org/article/accbfd0ef23b42d9ab053dea845af339
Autor:
C. Raina MacIntyre, J. Kevin Yin, Christian Felter, Robert I. Menzies, Edward Thommes, Nathalie Largeron, Aye M. Moa, Mallory Trent, Valentina Costantino, Seulki Choi, Fabián P. Alvarez
Publikováno v:
Vaccine: X, Vol 15, Iss , Pp 100365- (2023)
Background: Standard dose influenza vaccine provides moderate protection from infection, but with lower effectiveness among the elderly. High dose and adjuvanted vaccines (HD-TIV and aTIV) were developed to address this. This study aims to estimate t
Externí odkaz:
https://doaj.org/article/9be6f38f9364482fb3bc6700348632b0
Autor:
Robert P. Menzies
Publikováno v:
Conspectus, Vol 35, Pp 99-101 (2023)
Externí odkaz:
https://doaj.org/article/70c155f574e64a82bd6be2014d34bbd3
Autor:
Lisa Buvall, Robert I. Menzies, Julie Williams, Kevin J. Woollard, Chanchal Kumar, Anna B. Granqvist, Maria Fritsch, Denis Feliers, Anna Reznichenko, Davide Gianni, Slavé Petrovski, Claus Bendtsen, Mohammad Bohlooly-Y, Carolina Haefliger, Regina Fritsche Danielson, Pernille B. L. Hansen
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Kidney disease is a complex disease with several different etiologies and underlying associated pathophysiology. This is reflected by the lack of effective treatment therapies in chronic kidney disease (CKD) that stop disease progression. However, no
Externí odkaz:
https://doaj.org/article/6361614ed43a4724915ac1760b7334c8
Autor:
Robert I Menzies, Xin Zhao, Linda J Mullins, John J Mullins, Carolynn Cairns, Nicola Wrobel, Donald R Dunbar, Matthew A Bailey, Christopher J Kenyon
Publikováno v:
Endocrine Connections, Vol 6, Iss 7, Pp 446-457 (2017)
Chronic ACTH exposure is associated with adrenal hypertrophy and steroidogenesis. The underlying molecular processes in mice have been analysed by microarray, histological and immunohistochemical techniques. Synacthen infused for 2 weeks markedly inc
Externí odkaz:
https://doaj.org/article/604365f401a94798b5d7a9d9fb79dcb4
Autor:
Robert I. Menzies, John W.R. Booth, John J. Mullins, Matthew A. Bailey, Frederick W.K. Tam, Jill T. Norman, Robert J. Unwin
Publikováno v:
EBioMedicine, Vol 19, Iss C, Pp 73-83 (2017)
Diabetes is a leading cause of renal disease. Glomerular mesangial expansion and fibrosis are hallmarks of diabetic nephropathy and this is thought to be promoted by infiltration of circulating macrophages. Monocyte chemoattractant protein-1 (MCP-1)
Externí odkaz:
https://doaj.org/article/09543f448dd741b5bce76b3c6f64b596
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 12, Pp 1419-1433 (2016)
The rat has classically been the species of choice for pharmacological studies and disease modeling, providing a source of high-quality physiological data on cardiovascular and renal pathophysiology over many decades. Recent developments in genome en
Externí odkaz:
https://doaj.org/article/5e2b82ec40dd485d849c393926b5e345
Autor:
Vandana Veenit, Hiddo J L Heerspink, Christine Ahlstrom, Peter J Greasley, Stanko Skritic, Natalie van Zuydam, Donald E Kohan, Pernille B L Hansen, Robert I Menzies
Publikováno v:
Nephrology Dialysis Transplantation.
Background Endothelin A receptor antagonists (ETARA) slow chronic kidney disease (CKD) progression but their use is limited due to fluid retention and associated clinical risks. Sodium glucose cotransporter 2 inhibitors (SGLT2i) cause osmotic diuresi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fc177714633d8c65f19be771dac71a4
https://doi.org/10.1093/ndt/gfad078
https://doi.org/10.1093/ndt/gfad078