Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Robert A. Lazarus"'
Autor:
Henry R. Maun, Rajesh Vij, Benjamin T. Walters, Ashley Morando, Janet K. Jackman, Ping Wu, Alberto Estevez, Xiaocheng Chen, Yvonne Franke, Michael T. Lipari, Mark S. Dennis, Daniel Kirchhofer, Claudio Ciferri, Kelly M. Loyet, Tangsheng Yi, Charles Eigenbrot, Robert A. Lazarus, James T. Koerber
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
β-tryptases are responsible for most of the proteolytic activity during mast cell activation. Here, the authors develop β-tryptase-inhibiting antibodies and provide structural and biochemical evidence that the bivalency of the antibodies is a prere
Externí odkaz:
https://doaj.org/article/731be2a1b0e94f0d9e6e6bb1c65b39da
Autor:
Daniel Kirchhofer, Amitabha Chaudhuri, Robert A. Lazarus, Thomas D. Wu, Lydia Santell, Ming-Hong Xie, S. Jack Lin, Ganesh A. Kolumam, Rajkumar Ganesan
Macrophage-stimulating protein (MSP) is a plasminogen-related growth factor and ligand for the receptor tyrosine kinase RON. The MSP/RON system promotes wound healing and invasive tumor growth and suppresses proinflammatory immune response. MSP bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab92bcdb36a8748185ea7692af62458f
https://doi.org/10.1158/1541-7786.c.6542076
https://doi.org/10.1158/1541-7786.c.6542076
Autor:
Daniel Kirchhofer, Amitabha Chaudhuri, Robert A. Lazarus, Thomas D. Wu, Lydia Santell, Ming-Hong Xie, S. Jack Lin, Ganesh A. Kolumam, Rajkumar Ganesan
PDF file - 504K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25cea70a42c7644cf880ccb27c359620
https://doi.org/10.1158/1541-7786.22518687.v1
https://doi.org/10.1158/1541-7786.22518687.v1
Autor:
Joseph Chavarria-Smith, Cecilia P.C. Chiu, Janet K. Jackman, Jianping Yin, Juan Zhang, Jason A. Hackney, Wei-Yu Lin, Tulika Tyagi, Yonglian Sun, Janet Tao, Debra Dunlap, William D. Morton, Swapnil V. Ghodge, Henry R. Maun, Hong Li, Hilda Hernandez-Barry, Kelly M. Loyet, Emily Chen, John Liu, Christine Tam, Brian L. Yaspan, Hao Cai, Mercedesz Balazs, Joseph R. Arron, Jing Li, Arthur J Wittwer, Rajita Pappu, Cary D. Austin, Wyne P. Lee, Robert A. Lazarus, Jawahar Sudhamsu, James T. Koerber, Tangsheng Yi
Publikováno v:
Science Translational Medicine. 14
The epidermis is a barrier that prevents water loss while keeping harmful substances from penetrating the host. The impermeable cornified layer of the stratum corneum is maintained by balancing continuous turnover driven by epidermal basal cell proli
Autor:
James T. Koerber, Tracy Staton, Tangsheng Yi, Meire Bremer, Henry R. Maun, Saloumeh K Fischer, Robert A. Lazarus, Gizette Sperinde, Amos Baruch, Rajesh Vij
Publikováno v:
Bioanalysis. 12:1377-1388
Aim: Tryptase is a tetrameric trypsin-like serine protease contained within the secretory granules of mast cells and is an important mediator of allergic inflammatory responses in respiratory diseases. Detection of active tryptase in the airway may p
Autor:
Lawrence B. Schwartz, Andrea N. Naranjo, Quang T. Le, Joshua D. Milner, Jonathan J. Lyons, Robert A. Lazarus, Ana Olivera, Dean D. Metcalfe
Publikováno v:
The Journal of Experimental Medicine
Human α/β-tryptase heterotetramer, a previously hidden form of tryptase, explains some of the unusual clinical features of hereditary α-tryptasemia. α/β-Tryptase forms naturally in mast cells and, when secreted, activates clinically relevant pro
Autor:
Steven E Kauder, Lydia Santell, Elaine Mai, Lilyan Y Wright, Elizabeth Luis, Elsa N N'Diaye, Jeff Lutman, Navneet Ratti, Susan M Sa, Henry R Maun, Eric Stefanich, Lino C Gonzalez, Robert R Graham, Lauri Diehl, William A Faubion, Mary E Keir, Judy Young, Amitabha Chaudhuri, Robert A Lazarus, Jackson G Egen
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83958 (2013)
Macrophage stimulating protein (MSP) is a serum growth factor that binds to and activates the receptor tyrosine kinase, Recepteur d'Origine Nantais (RON). A non-synonymous coding variant in MSP (689C) has been associated with genetic susceptibility t
Externí odkaz:
https://doaj.org/article/6b29382e11a343b58a0d4a762432fc8a
Autor:
Kelly M. Loyet, Neil N. Trivedi, Racquel Corpuz, Brian L. Yaspan, Tracy Staton, Henry R. Maun, Erin H. Christensen, Kathila R. Alatsis, Xiumin Wu, Michael T. Lipari, Yvonne Franke, Mark S. Dennis, Daniel Kirchhofer, Wyne P. Lee, Rahul Ahuja, Xiaocheng Chen, Ashley Morando, Diana Chang, James T. Koerber, Aija Kusi, Joseph R. Arron, John Liu, Guiquan Jia, Juan Zhang, Janet Jackman, Ping Wu, George H. Caughey, Yan Wu, Rajesh Vij, Luz D. Orozco, Lawrence B. Schwartz, Benjamin T. Walters, Charles Eigenbrot, Prescott G. Woodruff, Lawren C. Wu, David F. Choy, Robert A. Lazarus, Meire Bremer, Amy Dressen, Magda Babina, Tangsheng Yi, Savita Ubhayakar, Xiaorong Liang, Jeff Lutman, Siddharth Sukumaran, Jason A. Hackney, John V. Fahy, Julie Q. Hang, Cary D. Austin, Manda Wong
Publikováno v:
Cell, vol 179, iss 2
Cell
Cell
Severe asthma patients with low type 2 inflammation derive less clinical benefit from therapies targeting type 2 cytokines and have significant unmet medical needs. We show that mast cell tryptase is elevated in severe asthma patients, correlating wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c0946c02d2066eb05676694e454e0e
https://escholarship.org/uc/item/8pf5p52n
https://escholarship.org/uc/item/8pf5p52n
Autor:
Charles Eigenbrot, William F. Forrest, Yvonne Franke, Henry R. Maun, Peter Liu, Lawrence B. Schwartz, Robert A. Lazarus
Publikováno v:
Journal of Biological Chemistry. 293:9614-9628
Human β-tryptase, a tetrameric trypsin-like serine protease, is an important mediator of the allergic inflammatory responses in asthma. During acute hypersensitivity reactions, mast cells degranulate, releasing active tetramer as a complex with prot
Autor:
Eric Suto, Jefferey Eastham‐Anderson, Lydia Santell, Peng Luan, Yanmei Lu, Yvonne Franke, Susan Haller, Maria Mouchess, Jason A. Hackney, Craig Blanchette, Christine Tam, Robert A. Lazarus, Sara Chan, Martine Darwish, Cary D. Austin, Dongping He, Wyne P. Lee, Bingbing Dai, Tangsheng Yi, Yi Cao
Publikováno v:
The FASEB Journal. 33