Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Robert A. Law"'
Autor:
James W. Hindley, Yuval Elani, Catriona M. McGilvery, Simak Ali, Charlotte L. Bevan, Robert V. Law, Oscar Ces
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-6 (2018)
Matryoshka doll-like, nested vesicles, each containing a different ingredient to a chemical reaction, can serve as microreactors. Here, the authors developed a system in which mixing of the ingredients can be induced by irradiation with ultraviolet l
Externí odkaz:
https://doaj.org/article/70757d22ec7b4fbd9828bd4dc7607b93
Autor:
Konstantinos Konstantopoulos, Lei Zheng, Jake M. Bieber, Robert A. Law, Soontorn Tuntithavornwat, Panagiotis Mistriotis, Daniel J. Shea, Bin Sheng Wong
PODXL knockdown impairs 2D random migration of metastatic pancreatic cancer cells. Representative scramble control (left) and PODXL-KD (right) SW1990 cells migrating on collagen I-coated glass coverslips. Scale bar represents 50 µm. Related to Fig.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50be4d4539af9b3ed28217f91339bc74
https://doi.org/10.1158/0008-5472.22421237.v1
https://doi.org/10.1158/0008-5472.22421237.v1
Autor:
Konstantinos Konstantopoulos, Lei Zheng, Jake M. Bieber, Robert A. Law, Soontorn Tuntithavornwat, Panagiotis Mistriotis, Daniel J. Shea, Bin Sheng Wong
Contains Supplementary Figures, Supplementary Figure Legends, Supplementary Video Legends, Supplementary Table and Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22badf1cb6c578e8d7b61f87cced0b86
https://doi.org/10.1158/0008-5472.22421240.v1
https://doi.org/10.1158/0008-5472.22421240.v1
Autor:
Konstantinos Konstantopoulos, Lei Zheng, Jake M. Bieber, Robert A. Law, Soontorn Tuntithavornwat, Panagiotis Mistriotis, Daniel J. Shea, Bin Sheng Wong
The sialoglycoprotein podocalyxin is absent in normal pancreas but is overexpressed in pancreatic cancer and is associated with poor clinical outcome. Here, we investigate the role of podocalyxin in migration and metastasis of pancreatic adenocarcino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2e1687e82d9f82542f5da8aad885238
https://doi.org/10.1158/0008-5472.c.6510866.v1
https://doi.org/10.1158/0008-5472.c.6510866.v1
Autor:
Konstantinos Konstantopoulos, Lei Zheng, Jake M. Bieber, Robert A. Law, Soontorn Tuntithavornwat, Panagiotis Mistriotis, Daniel J. Shea, Bin Sheng Wong
PODXL knockdown suppresses chemotactic migration of pancreatic cancer cells inside PDMS-based microchannels of prescribed widths. Representative scramble control (top) and PODXL-KD (bottom) cells migrating inside microchannels of 200 µm in length, 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4fe35f0b477233ae31c82fd6f72c07a
https://doi.org/10.1158/0008-5472.22421234.v1
https://doi.org/10.1158/0008-5472.22421234.v1
Publikováno v:
Journal of Non-Crystalline Solids: X, Vol 1, Iss , Pp - (2019)
Two series of glasses were produced by systematically substituting magnesium for calcium and strontium in the glass compositions, 4.5SiO2. 3Al2O3. 1.5P2O5. (3-x)CaO/SrO. xMgO. (2-y)CaF2/SrF2. yMgF2, 0 ≥ x ≥ 3, 0 ≥ y ≥ 2 and these glasses were
Externí odkaz:
https://doaj.org/article/bbc3ed42b4bb4154b373c4c5f78eb52a
Autor:
Robert A. Law, Alexander Kiepas, Habben E. Desta, Emiliano Perez Ipiña, Maria Parlani, Se Jong Lee, Christopher L. Yankaskas, Runchen Zhao, Panagiotis Mistriotis, Nianchao Wang, Zhizhan Gu, Petr Kalab, Peter Friedl, Brian A. Camley, Konstantinos Konstantopoulos
Publikováno v:
Science Advances, 9, 2
Science Advances, 9
Science Advances, 9
Supplementary code - Cytokinesis machinery promotes cell dissociation from collectively migrating strands in confinement - Robert A. Law, Alexander Kiepas, Habben E. Desta, Emiliano Perez Ipiña**, Maria Parlani, Se Jong Lee, Chris L. Yankaskas, Runc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e866c045ff2ea29598eb8ac29aa73020
Autor:
Han Dai, Robert P. Law, John P. Evans, Gillian F. Watt, Chun-wa Chung, Markus A. Queisser, John D. Harling, Antonia J. Lewis, Marcus Bantscheff, João Osvaldo Rodrigues Nunes, Adam Flinders, Paul Scott-Stevens, Andrew B. Benowitz, Peter Stacey, Christopher J. Tame, Karol Buda, Diana Klimaszewska, Marcel Muelbaier, Nico Zinn
Publikováno v:
Angewandte Chemie. 133:23515-23522
Focal adhesion kinase (FAK) is a key mediator of tumour progression and metastasis. To date, clinical trials of FAK inhibitors have reported disappointing efficacy for oncology indications. We report the design and characterisation of GSK215, a poten
Autor:
Peter Stacey, Gopal P. Sapkota, Georgina Green, Hannah Lithgow, Marcel Muelbaier, Glenn A. Burley, Andrew B. Benowitz, Ian Edward David Smith, Xiao Qing Lewell, Ryan Whatling, Markus A. Queisser, Agnieszka Konopacka, Robert P. Law, Stephen Besley, John D. Harling, Sascha Röth
Publikováno v:
SLAS Discovery. 26:885-895
Targeted protein degradation is an emerging new strategy for the modulation of intracellular protein levels with applications in chemical biology and drug discovery. One approach to enable this strategy is to redirect the ubiquitin-proteasome system