Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Robert A. Kumpf"'
Autor:
Thomas A. Paul, Martin Wythes, Fen Wang, Michelle Tran-Dube, Stephanie Scales, Eugene Rui, Ryan L. Patman, Wei Liu, Robert A. Kumpf, Susan E. Kephart, Vesta Goshtasbi, Ya-Li Deng, Alexei Brooun, John Braganza, Prakash Palde, Shannon Karlicek Bryant, Elizabeth A. McMillan, Chi-Yeh Chung, John Sherrill, Hieu Lam, Eleanore Hendrickson, Natalie Miller, Amy Nemeth, Manli Shi, Noah Spiegel, Shinji Yamazaki, Yuli Wang, Christopher P. Dillon, Tao Xie, Michele McTigue, Indrawan J. McAlpine, Karen A. Maegley, John Tatlock, Kristen Jensen-Pergakes
Supplemental Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46922fa072a5bd8d00c642d9ca4b1236
https://doi.org/10.1158/1535-7163.22522828.v1
https://doi.org/10.1158/1535-7163.22522828.v1
Autor:
Thomas A. Paul, Martin Wythes, Fen Wang, Michelle Tran-Dube, Stephanie Scales, Eugene Rui, Ryan L. Patman, Wei Liu, Robert A. Kumpf, Susan E. Kephart, Vesta Goshtasbi, Ya-Li Deng, Alexei Brooun, John Braganza, Prakash Palde, Shannon Karlicek Bryant, Elizabeth A. McMillan, Chi-Yeh Chung, John Sherrill, Hieu Lam, Eleanore Hendrickson, Natalie Miller, Amy Nemeth, Manli Shi, Noah Spiegel, Shinji Yamazaki, Yuli Wang, Christopher P. Dillon, Tao Xie, Michele McTigue, Indrawan J. McAlpine, Karen A. Maegley, John Tatlock, Kristen Jensen-Pergakes
ElasticNet Tables for PF-06939999 in NSCLC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2702f62418df5f02af2f23bc6d583fa7
https://doi.org/10.1158/1535-7163.22522837
https://doi.org/10.1158/1535-7163.22522837
Autor:
Thomas A. Paul, Martin Wythes, Fen Wang, Michelle Tran-Dube, Stephanie Scales, Eugene Rui, Ryan L. Patman, Wei Liu, Robert A. Kumpf, Susan E. Kephart, Vesta Goshtasbi, Ya-Li Deng, Alexei Brooun, John Braganza, Prakash Palde, Shannon Karlicek Bryant, Elizabeth A. McMillan, Chi-Yeh Chung, John Sherrill, Hieu Lam, Eleanore Hendrickson, Natalie Miller, Amy Nemeth, Manli Shi, Noah Spiegel, Shinji Yamazaki, Yuli Wang, Christopher P. Dillon, Tao Xie, Michele McTigue, Indrawan J. McAlpine, Karen A. Maegley, John Tatlock, Kristen Jensen-Pergakes
Supplemental Figures S1-S8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37771825e5ee666377a34886744f4a83
https://doi.org/10.1158/1535-7163.22522831
https://doi.org/10.1158/1535-7163.22522831
Autor:
Thomas A. Paul, Martin Wythes, Fen Wang, Michelle Tran-Dube, Stephanie Scales, Eugene Rui, Ryan L. Patman, Wei Liu, Robert A. Kumpf, Susan E. Kephart, Vesta Goshtasbi, Ya-Li Deng, Alexei Brooun, John Braganza, Prakash Palde, Shannon Karlicek Bryant, Elizabeth A. McMillan, Chi-Yeh Chung, John Sherrill, Hieu Lam, Eleanore Hendrickson, Natalie Miller, Amy Nemeth, Manli Shi, Noah Spiegel, Shinji Yamazaki, Yuli Wang, Christopher P. Dillon, Tao Xie, Michele McTigue, Indrawan J. McAlpine, Karen A. Maegley, John Tatlock, Kristen Jensen-Pergakes
Whole exome sequencing results from PRMT5 inhibitor resistant cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15cdb7d2fd2233079984a0b743edb087
https://doi.org/10.1158/1535-7163.22522843
https://doi.org/10.1158/1535-7163.22522843
Autor:
Thomas A. Paul, Martin Wythes, Fen Wang, Michelle Tran-Dube, Stephanie Scales, Eugene Rui, Ryan L. Patman, Wei Liu, Robert A. Kumpf, Susan E. Kephart, Vesta Goshtasbi, Ya-Li Deng, Alexei Brooun, John Braganza, Prakash Palde, Shannon Karlicek Bryant, Elizabeth A. McMillan, Chi-Yeh Chung, John Sherrill, Hieu Lam, Eleanore Hendrickson, Natalie Miller, Amy Nemeth, Manli Shi, Noah Spiegel, Shinji Yamazaki, Yuli Wang, Christopher P. Dillon, Tao Xie, Michele McTigue, Indrawan J. McAlpine, Karen A. Maegley, John Tatlock, Kristen Jensen-Pergakes
AUC and EC50 values for PF-06939999 treated NSCLC cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d7e8a99f10477f087966473edb7804
https://doi.org/10.1158/1535-7163.22522840
https://doi.org/10.1158/1535-7163.22522840
Autor:
Karen A. Maegley, Kephart Susan Elizabeth, Christopher P. Dillon, Manli Shi, Kristen Jensen-Pergakes, Prakash B. Palde, Ya-Li Deng, Chi-Yeh Chung, Natalie Miller, John Sherrill, Wei Liu, Ryan L. Patman, Shinji Yamazaki, Tao Xie, Fen Wang, Hieu Lam, Eleanore Hendrickson, John F. Braganza, Yuli Wang, Robert Arnold Kumpf, Shannon Karlicek Bryant, Thomas A Paul, Noah Spiegel, Martin James Wythes, Amy Nemeth, Stephanie Scales, Elizabeth A. McMillan, Michelle Tran-Dubé, Alexei Brooun, Vesta Goshtasbi, Eugene Rui, Michele McTigue, Indrawan James Mcalpine, Tatlock John H
Publikováno v:
Molecular Cancer Therapeutics. 21:3-15
Protein arginine methyltransferase 5 (PRMT5) overexpression in hematologic and solid tumors methylates arginine residues on cellular proteins involved in important cancer functions including cell-cycle regulation, mRNA splicing, cell differentiation,
Autor:
Simon Stael, Igor Sabljić, Dominique Audenaert, Thilde Andersson, Liana Tsiatsiani, Robert P. Kumpf, Andreu Vidal-Albalat, Cecilia Lindgren, Dominique Vercammen, Silke Jacques, Long Nguyen, Maria Njo, Álvaro D. Fernández-Fernández, Tine Beunens, Evy Timmerman, Kris Gevaert, Marc Van Montagu, Jerry Ståhlberg, Peter V. Bozhkov, Anna Linusson, Tom Beeckman, Frank Van Breusegem
Publikováno v:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Metacaspases are part of an evolutionarily broad family of multifunctional cysteine proteases, involved in disease and normal development. As the structure–function relationship of metacaspases remains poorly understood, we solved the X-ray crystal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e723d766be26d46f724c1998cc309b79
https://biblio.ugent.be/publication/01H1BBT35J1JZDAM2WQF7EAVEJ
https://biblio.ugent.be/publication/01H1BBT35J1JZDAM2WQF7EAVEJ
Autor:
Michael R. Collins, Robert Steven Kania, Connie Fan, Sutton Scott Channing, Dominique Verhelle, Kephart Susan Elizabeth, Martin James Wythes, Shuiwang Wang, Karen A. Maegley, Lisa Nguyen, Daniel Tyler Richter, A.E. Stewart, Pei-Pei Kung, Buwen Huang, Shikhar Sharma, Shinji Yamazaki, Ya-Li Deng, Rita Grantner, Patrick Bingham, Robert Arnold Kumpf, Penney Khamphavong, Jinjiang Zhu, Dac M. Dinh, Manfred Kraus, Wei Liu, Sean Uryu, Jillian E. Spangler, Wenyue Hu, Hui Wang, Robert A. Rollins, Cody Krivacic, Zehnder Luke Raymond, Neal W. Sach, Alexei Brooun, John Sherrill, Shijian Ren, Martin A. Edwards, Huichun Zhu, Ketan S. Gajiwala, Shuibo Xin, Hovhannes J. Gukasyan
Publikováno v:
Journal of Medicinal Chemistry. 61:650-665
A new series of lactam-derived EZH2 inhibitors was designed via ligand-based and physicochemical-property-based strategies to address metabolic stability and thermodynamic solubility issues associated with previous lead compound 1. The new inhibitors
Autor:
Eleanore Hendrickson, Martin James Wythes, Indrawan James Mcalpine, Karen A. Maegley, Christopher P. Dillon, Fen Wang, Kephart Susan Elizabeth, Amy Nemeth, Prakash B. Palde, Manli Shi, Kristen Jensen-Pergakes, Shinji Yamazaki, Tao Xie, Chi-Yeh Chung, Michelle Tran-Dubé, Tatlock John H, Stephanie Scales, Hieu Lam, Eugene Rui, Thomas A Paul, Elizabeth A. McMillan, Robert Arnold Kumpf, Ryan L. Patman, Michele McTigue, Natalie Miller, Ya-Li Deng, Yuli Wang, Noah Spiegel, Alexei Brooun, John Sherrill, Wei Liu, John F. Braganza
Publikováno v:
Cancer Research. 81:1160-1160
Protein arginine methyltransferase 5 (PRMT5) overexpression in hematological and solid tumors promotes symmetrical di-methyl arginine (SDMA) on cellular proteins involved in important cancer functions including cell cycle regulation, mRNA splicing, c
Autor:
Dafydd R. Owen, Aiping Dong, Martin James Wythes, Steven Kennedy, Dalia Barsyte-Lovejoy, Matthieu Schapira, Hong Wu, Rajiah Aldrin Denny, Viacheslav V. Trush, Mihir D. Parikh, Agustin Casimiro-Garcia, Renato Ferreira de Freitas, Masoud Vedadi, Magdalena Swewczyk, Hong Zeng, Tatlock John H, Fengling Li, Alexandria P. Taylor, Robert Arnold Kumpf, Peter Brown, Cheryl H. Arrowsmith
Publikováno v:
Journal of medicinal chemistry. 62(17)
The first chemical probe to primarily occupy the co-factor binding site of a Su(var)3-9, enhancer of a zeste, trithorax (SET) domain containing protein lysine methyltransferase (PKMT) is reported. Protein methyltransferases require S-adenosylmethioni