Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Robert A. Koza"'
Autor:
Rea Victoria P. Anunciado-Koza, Anyonya R. Guntur, Calvin P. Vary, Carlos A. Gartner, Madeleine Nowak, Robert A. Koza
Publikováno v:
BMC Research Notes, Vol 16, Iss 1, Pp 1-7 (2023)
Abstract Objective Our goal was to isolate purified mitochondria from mouse skeletal muscle using a Percoll density gradient and to assess bioenergetic function and purity via Seahorse Extracellular Flux (XF) Analyses and mass spectrometry. Results M
Externí odkaz:
https://doaj.org/article/7b5b03ab87174ad39cfc3280d4ed208e
Publikováno v:
Adipocyte, Vol 10, Iss 1, Pp 574-586 (2021)
Expansion of visceral white adipose tissue (vWAT) occurs in response to nutrient excess, and is a risk factor for metabolic disease. SPRY1, a feedback inhibitor of receptor tyrosine kinase (RTK) signaling, is expressed in PDGFRa+ adipocyte progenitor
Externí odkaz:
https://doaj.org/article/dfd1f8d43a5c4d89876a7a582db6fd13
Autor:
Bingzhong Xue, Jong-Seop Rim, Jessica C. Hogan, Ann A. Coulter, Robert A. Koza, Leslie P. Kozak
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 1, Pp 41-51 (2007)
Cold exposure induces brown adipocytes in retroperitoneal fat (RP) of adult A/J mice but not in C57BL/6J (B6) mice. In contrast, induction of the mitochondrial uncoupling protein 1 gene (Ucp1) in interscapular brown adipose tissue (iBAT) shows no str
Externí odkaz:
https://doaj.org/article/6fc2bb2c2f154af1a106556517264bb6
Publikováno v:
Adipocyte
article-version (VoR) Version of Record
Adipocyte, Vol 10, Iss 1, Pp 574-586 (2021)
article-version (VoR) Version of Record
Adipocyte, Vol 10, Iss 1, Pp 574-586 (2021)
Expansion of visceral white adipose tissue (vWAT) occurs in response to nutrient excess, and is a risk factor for metabolic disease. SPRY1, a feedback inhibitor of receptor tyrosine kinase (RTK) signaling, is expressed in PDGFRa+ adipocyte progenitor
Autor:
Peter C. Reifsnyder, Kevin Flurkey, Rosalinda Doty, Nigel A. Calcutt, Robert A. Koza, David E. Harrison
Publikováno v:
Aging cell, vol 21, iss 9
Rapamycin treatment has positive and negative effects on progression of type 2 diabetes (T2D) in a recombinant inbred polygenic mouse model, male NONcNZO10/LtJ (NcZ10). Here, we show that combination treatment with metformin ameliorates negative effe
Autor:
Igor Prudovsky, Sergey Ryzhov, Michael P. Robich, Amanda J. Favreau-Lessard, Robert A. Koza, Yodit R. Herrmann, Douglas B. Sawyer, Haifeng Yin, Joanne T. deKay
Publikováno v:
Journal of Molecular and Cellular Cardiology. 152:1-16
Background Myeloid cells play an important role in a wide variety of cardiovascular disorders, including both ischemic and non-ischemic cardiomyopathies. Neuregulin-1 (NRG-1)/ErbB signaling has recently emerged as an important factor contributing to
Autor:
Gene P. Ables, Diana Cooke, Dwight A.L. Mattocks, Rea P. Anunciado-Koza, Sailendra N. Nichenametla, Robert A. Koza
Publikováno v:
Obesity (Silver Spring)
Objective Identifying novel approaches to combat obesity is important to improve health span. It was hypothesized that methionine restriction (MR) will induce weight loss in obese mice by reducing adipose tissue mass caused by increased energy expend
Publikováno v:
PLOS ONE. 17:e0271913
Mesoderm specific transcript (Mest)/paternally expressed gene-1 (Peg1) is an imprinted gene expressed predominantly from the paternal allele. Aberrations in maternal behavior were previously reported in a Mest global knockout mouse (Mesttm1Masu). In
Autor:
Kevin Flurkey, Ian Mills, Peter C. Reifsnyder, Sergey Ryzhov, David E. Harrison, Rea P. Anunciado-Koza, Robert A. Koza
Publikováno v:
Annals of the New York Academy of Sciences. 1418:106-117
Rapamycin (RAPA), an inhibitor of mTORC signaling, has been shown to extend life span in mice and other organisms. Recently, animal and human studies have suggested that inhibition of mTORC signaling can alleviate or prevent the development of cardio
Autor:
Igor Prudovsky, Chester G. Jacobs, Robert A. Koza, Rea P. Anunciado-Koza, Matthew E. Siviski, Doreen Kacer
Publikováno v:
Journal of Cellular Biochemistry. 119:2636-2645
Highly variable expression of mesoderm-specific transcript (Mest) in adipose tissue among genetically homogeneous mice fed an obesogenic diet, and its positive association with fat mass expansion, suggests that Mest is an epigenetic determinant for t