Zobrazeno 1 - 10
of 1 347
pro vyhledávání: '"Robert A. Klein"'
Autor:
Robert J. Klein, Emily Vertosick, Dan Sjoberg, David Ulmert, Ann-Charlotte Rönn, Christel Häggström, Elin Thysell, Göran Hallmans, Anders Dahlin, Pär Stattin, Olle Melander, Andrew Vickers, Hans Lilja
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-8 (2022)
Abstract Polygenic risk scores (PRS) for prostate cancer incidence have been proposed to optimize prostate cancer screening. Prediction of lethal prostate cancer is key to any stratified screening program to avoid excessive overdiagnosis. Herein, PRS
Externí odkaz:
https://doaj.org/article/5f0a0b867c3d40ad97478098664fd2bd
Autor:
Sanjay M. Prakadan, Christopher A. Alvarez-Breckenridge, Samuel C. Markson, Albert E. Kim, Robert H. Klein, Naema Nayyar, Andrew W. Navia, Benjamin M. Kuter, Kellie E. Kolb, Ivanna Bihun, Joana L. Mora, Mia Solana Bertalan, Brian Shaw, Michael White, Alexander Kaplan, Jackson H. Stocking, Marc H. Wadsworth, Eudocia Q. Lee, Ugonma Chukwueke, Nancy Wang, Megha Subramanian, Denisse Rotem, Daniel P. Cahill, Viktor A. Adalsteinsson, Jeffrey W. Miller, Ryan J. Sullivan, Scott L. Carter, Priscilla K. Brastianos, Alex K. Shalek
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Leptomeningeal disease (LMD) is a serious complication of metastatic solid tumors with a poor prognosis. Here, by using single-cell RNA sequencing of cerebrospinal fluid, the authors report genomic and immune correlates of response to immunotherapy i
Externí odkaz:
https://doaj.org/article/687017c072604770afffff35e85435f2
Autor:
Alyssa L. Kennedy, Kasiani C. Myers, James Bowman, Christopher J. Gibson, Nicholas D. Camarda, Elissa Furutani, Gwen M. Muscato, Robert H. Klein, Kaitlyn Ballotti, Shanshan Liu, Chad E. Harris, Ashley Galvin, Maggie Malsch, David Dale, John M. Gansner, Taizo A. Nakano, Alison Bertuch, Adrianna Vlachos, Jeffrey M. Lipton, Paul Castillo, James Connelly, Jane Churpek, John R. Edwards, Nobuko Hijiya, Richard H. Ho, Inga Hofmann, James N. Huang, Siobán Keel, Adam Lamble, Bonnie W. Lau, Maxim Norkin, Elliot Stieglitz, Wendy Stock, Kelly Walkovich, Steffen Boettcher, Christian Brendel, Mark D. Fleming, Stella M. Davies, Edie A. Weller, Christopher Bahl, Scott L. Carter, Akiko Shimamura, R. Coleman Lindsley
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Understanding the molecular basis of leukaemia predisposition is essential for intervention. The authors here investigate germline genetic leukaemia predisposition by studying Shwachman-Diamond syndrome and report compensatory inactivating mutations
Externí odkaz:
https://doaj.org/article/911d91b30d4548af8f9e72d025592f4b
Autor:
Weiva Sieh, Joseph H. Rothstein, Robert J. Klein, Stacey E. Alexeeff, Lori C. Sakoda, Eric Jorgenson, Russell B. McBride, Rebecca E. Graff, Valerie McGuire, Ninah Achacoso, Luana Acton, Rhea Y. Liang, Jafi A. Lipson, Daniel L. Rubin, Martin J. Yaffe, Douglas F. Easton, Catherine Schaefer, Neil Risch, Alice S. Whittemore, Laurel A. Habel
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Mammographic density represents one the strongest predictors of breast cancer risk. Here the authors perform genome-wide association study meta-analysis of women screened with full-field digital mammography and identify 31 previously unreported loci
Externí odkaz:
https://doaj.org/article/455a1267540b4504a0c8a2bad60954fb
Autor:
Jing Zhang, Donghoon Lee, Vineet Dhiman, Peng Jiang, Jie Xu, Patrick McGillivray, Hongbo Yang, Jason Liu, William Meyerson, Declan Clarke, Mengting Gu, Shantao Li, Shaoke Lou, Jinrui Xu, Lucas Lochovsky, Matthew Ung, Lijia Ma, Shan Yu, Qin Cao, Arif Harmanci, Koon-Kiu Yan, Anurag Sethi, Gamze Gürsoy, Michael Rutenberg Schoenberg, Joel Rozowsky, Jonathan Warrell, Prashant Emani, Yucheng T. Yang, Timur Galeev, Xiangmeng Kong, Shuang Liu, Xiaotong Li, Jayanth Krishnan, Yanlin Feng, Juan Carlos Rivera-Mulia, Jessica Adrian, James R Broach, Michael Bolt, Jennifer Moran, Dominic Fitzgerald, Vishnu Dileep, Tingting Liu, Shenglin Mei, Takayo Sasaki, Claudia Trevilla-Garcia, Su Wang, Yanli Wang, Chongzhi Zang, Daifeng Wang, Robert J. Klein, Michael Snyder, David M. Gilbert, Kevin Yip, Chao Cheng, Feng Yue, X. Shirley Liu, Kevin P. White, Mark Gerstein
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
ENCODE is a resource comprising thousands of functional genomic datasets. Here, the authors present custom annotation within ENCODE for cancer, highlighting a workflow that can help prioritise key elements in oncogenesis.
Externí odkaz:
https://doaj.org/article/d3ef1766b33842a5aa6bd3194efeba4e
Publikováno v:
PLoS ONE, Vol 17, Iss 5 (2022)
Previous research has demonstrated that adults with comorbid depressive and anxiety disorders are significantly more likely to show pathological use of drugs or alcohol. Few studies, however, have examined associations of this type in children. A bet
Externí odkaz:
https://doaj.org/article/b741c39384664409a7a757b598ccd157
Publikováno v:
Internet Interventions, Vol 25, Iss , Pp 100424- (2021)
Introduction: Online social networking data (SN) is a contextually and temporally rich data stream that has shown promise in the prediction of suicidal thought and behavior. Despite the clear advantages of this digital medium, predictive modeling of
Externí odkaz:
https://doaj.org/article/7a305050cefe4bfba04c7157f749cf65
Autor:
Raina N. Fichorova, Allison K. DeLong, Susan Cu-Uvin, Caroline C. King, Denise J. Jamieson, Robert S. Klein, Jack D. Sobel, David Vlahov, Hidemi S. Yamamoto, Kenneth H. Mayer
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Co-infections with sexually transmittable pathogens are common and more likely in women with disturbed vaginal bacteriome. Among those pathogens, the protozoan parasite Trichomonas vaginalis (TV) is most common after accounting for the highly persist
Externí odkaz:
https://doaj.org/article/3546cc4120a84297a77c3c43fe886721
Publikováno v:
Emotion. 23:911-924
According to psychological flexibility theory, fully experiencing one's emotions, even when they involve negative reactions, can enhance psychological well-being. In pursuit of this possibility, procedures capable of disentangling reaction intensitie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485a36fe1c78cd31f191a7c373150b83
https://doi.org/10.1037/emo0001159
https://doi.org/10.1037/emo0001159
Autor:
Daniel Crozier, Fabian Leon, Jales M. O. Fonseca, Patricia E. Klein, Robert R. Klein, William L. Rooney
Publikováno v:
Crop Science. 63:1183-1196
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45fc3c48ee6d56ef82bd93f87c677744
https://doi.org/10.1002/csc2.20927
https://doi.org/10.1002/csc2.20927