Výsledky vyhledávání - "Robert A. Ivey"

Akademický článek

Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation

Autor: Mini P. Sajan, Robert A. Ivey, Mackenzie C. Lee, Robert V. Farese

Publikováno v: Journal of Lipid Research, Vol 56, Iss 1, Pp 70-80 (2015)

Pathogenesis of insulin resistance in leptin-deficient ob/ob mice is obscure. In another form of diet-dependent obesity, high-fat-fed mice, hepatic insulin resistance involves ceramide-induced activation of atypical protein kinase C (aPKC), which sel

Externí odkaz: https://doaj.org/article/dda2d6e8d0d34a14b1b39e6fa81aea0a

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Autor: Robert V. Farese, Mini P. Sajan, Robert A. Ivey

Publikováno v: Metabolism. 64:1454-1465

Information on insulin resistance in human liver is limited. In mouse diet-induced obesity (DIO), hepatic insulin resistance initially involves: lipid + insulin-induced activation of atypical protein kinase C (aPKC); elevated Akt activity/activation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f33875c020c7017146cd404d28e04bd8
https://doi.org/10.1016/j.metabol.2015.08.011

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Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation

Autor: Robert V. Farese, Mini P. Sajan, Mackenzie C. Lee, Robert A. Ivey

Publikováno v: Journal of Lipid Research, Vol 56, Iss 1, Pp 70-80 (2015)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02cd806ade826898da8f21d36616d56d
http://www.sciencedirect.com/science/article/pii/S0022227520356418

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Akt-Dependent Phosphorylation of Hepatic FoxO1 Is Compartmentalized on a WD40/ProF Scaffold and Is Selectively Inhibited by aPKC in Early Phases of Diet-Induced Obesity

Autor: Mini P. Sajan, Robert V. Farese, Mackenzie C. Lee, Mary L. Standaert, Mildred Acevedo-Duncan, Robert A. Ivey

Publikováno v: Diabetes

Initiating mechanisms that impair gluconeogenic enzymes and spare lipogenic enzymes in diet-induced obesity (DIO) are obscure. Here, we examined insulin signaling to Akt and atypical protein kinase C (aPKC) in liver and muscle and hepatic enzyme expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f074cdecc8d5904ba45e825ca128da09
https://doi.org/10.2337/db13-1863

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Perceptions of the Future of Cataloging: Is the Sky Really Falling?

Autor: Robert T. Ivey

Publikováno v: Cataloging & Classification Quarterly. 47:464-482

Cataloging procedures have evolved in many academic research libraries over the past 10 years. Some predicted trends—outsourcing, original cataloging by paraprofessionals, more digital material—have been borne out. Others, such as a decline in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0eca3baa16640e2d8d48afb0514adb75
https://doi.org/10.1080/01639370902832645

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Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1-40/42 and Phospho-Tau May Abet Alzheimer Development

Autor: Shijie Song, Robert V. Farese, Csilla Ari, Barbara C. Hansen, Michael Leitges, Robert A. Ivey, Margaret Farese-Higgs, Joshua Sajan, Ursula Braun, Mini P. Sajan

Publikováno v: Diabetes

Increased coexistence of Alzheimer disease (AD) and type 2 diabetes mellitus (T2DM) suggests that insulin resistance abets neurodegenerative processes, but linkage mechanisms are obscure. Here, we examined insulin signaling factors in brains of insul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e52b12b02e56e80faa9ca9f9573bd9
https://pubmed.ncbi.nlm.nih.gov/26895791

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Crystallographic Structure of a Rheumatoid Arthritis MHC Susceptibility Allele, HLA-DR1 (DRB1*0101), Complexed with the Immunodominant Determinant of Human Type II Collagen

Autor: Karen B. Whittington, Andrew H. Kang, Edward F. Rosloniec, Robert A. Ivey, Hee-Won Park

Publikováno v: The Journal of Immunology. 177:3884-3892

The expression of HLA-DR1 (DRB1*0101) is associated with an enhanced risk for developing rheumatoid arthritis (RA). To study its function, we have solved the three-dimensional structure of HLA-DR1 complexed with a candidate RA autoantigen, the human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc08affcd40b0cea5d13420291f4c1d0
https://doi.org/10.4049/jimmunol.177.6.3884

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Requirements for Pseudosubstrate Arginine Residues during Autoinhibition and Phosphatidylinositol 3,4,5-(PO4)3-dependent Activation of Atypical PKC*

Autor: Robert V. Farese, Mini P. Sajan, Robert A. Ivey

Atypical PKC (aPKC) isoforms are activated by the phosphatidylinositol 3-kinase product phosphatidylinositol 3,4,5-(PO4)3 (PIP3). How PIP3 activates aPKC is unknown. Although Akt activation involves PIP3 binding to basic residues in the Akt pleckstri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25ba8f9bef0db9dcc2ffe21d2da61cc6
https://europepmc.org/articles/PMC4155669/

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PKCλ Haploinsufficiency Prevents Diabetes by a Mechanism Involving Alterations in Hepatic Enzymes

Autor: Ursula Braun, Michael J. Jurczak, Michael Leitges, Gerald I. Shulman, Varman T. Samuels, Stephen Mastorides, Robert V. Farese, Robert A. Ivey, Mini P. Sajan, Mackenzie C. Lee

Tissue-specific knockout (KO) of atypical protein kinase C (aPKC), PKC-λ, yields contrasting phenotypes, depending on the tissue. Thus, whereas muscle KO of PKC-λ impairs glucose transport and causes glucose intolerance, insulin resistance, and liv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f3bc939935cf5dfca7953a882a65d9
https://europepmc.org/articles/PMC4075159/

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