Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Robert A. Holmgren"'
Autor:
Amira Brigui, Line Hofmann, Camilla Argüelles, Matthieu Sanial, Robert A. Holmgren, Anne Plessis
Publikováno v:
Open Biology, Vol 5, Iss 10 (2015)
The conserved Hedgehog (HH) signals control animal development, adult stem cell maintenance and oncogenesis. In Drosophila, the HH co-receptor Patched (PTC) controls both HH gradient formation and signalling. PTC is post-translationally downregulated
Externí odkaz:
https://doaj.org/article/410696e8da2945b883f7b008fdc26fea
Publikováno v:
Development. 149
Morphogen gradients need to be robust, but may also need to be tailored for specific tissues. Often this type of regulation is carried out by negative regulators and negative feedback loops. In the Hedgehog (Hh) pathway, activation of patched (ptc) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab8aa528210f035f043885c74673ea0
https://doi.org/10.1242/dev.200159
https://doi.org/10.1242/dev.200159
Autor:
Meghan W. Dukes, Elizabeth A. Bajema, Tyler J. Whittemore, Robert A. Holmgren, Thomas J. Meade
Publikováno v:
Bioconjugate chemistry. 33(4)
The Hedgehog (Hh) signaling pathway is integral for embryonic development and normal cell maintenance. However, aberrant expression of the Hh pathway is recognized as the oncogenic driving force for basal cell carcinoma (BCC). Current chemotherapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f549ed8d0e380946ba94889389e940de
https://pubmed.ncbi.nlm.nih.gov/35271256
https://pubmed.ncbi.nlm.nih.gov/35271256
Autor:
Lucia Bruzzone, Isabelle Becam, Marina Gonçalves-Antunes, Robert A. Holmgren, Howard D. Lipshitz, Craig A. Smibert, Anne Plessis, Fairouz Qasrawi, Giorgia Alvisi, Graciela Lidia Boccaccio, Camilla Argüelles, Matthieu Sanial, Samia Miled
Publikováno v:
EMBO Rep
From fly to mammals, the Smaug/Samd4 family of prion-like RNA-binding proteins control gene expression by destabilizing and/or repressing the translation of numerous target transcripts. However, the regulation of its activity remains poorly understoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a0599ac2238d1977dff4f1b8bdf7fa
https://doi.org/10.15252/embr.201948425
https://doi.org/10.15252/embr.201948425
Autor:
Matthieu Sanial, Line Hofmann, Julien Béhague, Vanessa Gourhand, Lucia Bruzzone, Anne Plessis, Camilla Argüelles, Robert A. Holmgren, Isabelle Becam
Publikováno v:
Development.
Smoothened (SMO) is a G-protein-coupled receptor-related protein required for the transduction of Hedgehog (HH). The HH gradient leads to graded phosphorylation of SMO, mainly by the PKA and CKI kinases. How thresholds in HH morphogen regulate SMO to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::369f3fc2c8001472176c516cda36706f
https://doi.org/10.1242/dev.144782
https://doi.org/10.1242/dev.144782
Autor:
Matthieu, Sanial, Isabelle, Bécam, Line, Hofmann, Julien, Behague, Camilla, Argüelles, Vanessa, Gourhand, Lucia, Bruzzone, Robert A, Holmgren, Anne, Plessis
Publikováno v:
Development (Cambridge, England). 144(10)
Smoothened (SMO) is a G-protein-coupled receptor-related protein required for the transduction of Hedgehog (HH). The HH gradient leads to graded phosphorylation of SMO, mainly by the PKA and CKI kinases. How thresholds in HH morphogen regulate SMO to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a381b32909ed5a4545cee6b2c5b53bb6
https://pubmed.ncbi.nlm.nih.gov/28360132
https://pubmed.ncbi.nlm.nih.gov/28360132
Autor:
Thomas J. Meade, Robert J. Holbrook, Robert A. Holmgren, Marie C. Heffern, Allison S. Harney, Ryan R. Hurtado
Publikováno v:
Molecular Pharmaceutics. 9:325-333
We describe the use of Co(III) Schiff base-DNA conjugates, a versatile class of research tools that target C2H2 transcription factors, to inhibit the Hedgehog (Hh) pathway. In developing mammalian embryos, Hh signaling is critical for the formation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6ff2397fe60c64802636746b2a7ce78
https://doi.org/10.1021/mp2005577
https://doi.org/10.1021/mp2005577
Publikováno v:
Journal of Biological Chemistry. 286:39051-39058
The Gli proteins are the transcriptional effectors of the mammalian Hedgehog signaling pathway. In an unusual mechanism, the proteasome partially degrades or processes Gli3 in the absence of Hedgehog pathway stimulation to create a Gli3 fragment that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac83bbfa6829622ce4d9a9be8a2e0f94
https://doi.org/10.1074/jbc.m111.274993
https://doi.org/10.1074/jbc.m111.274993
Publikováno v:
Developmental Biology. 294:258-270
The Hedgehog (Hh) signal transduction pathway plays a central role in the development of invertebrates and vertebrates. While much is known about the pathway, the role of Suppressor of fused (Su(fu)), a component of the pathway's signaling complex ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8c97203fc032d3909c4398ecd7a394
https://doi.org/10.1016/j.ydbio.2006.02.050
https://doi.org/10.1016/j.ydbio.2006.02.050
Publikováno v:
Developmental Biology. 236:411-420
Much of our understanding of the Hedgehog (Hh) signaling pathway comes from Drosophila, where a gradient of Hh signaling regulates the function of the transcription factor Cubitus interruptus (Ci) at three levels: protein stabilization, nuclear impor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1761711e8904f3014e7ae02397dd1ea1
https://doi.org/10.1006/dbio.2001.0345
https://doi.org/10.1006/dbio.2001.0345