Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Robert A. Hazlitt"'
Autor:
Robert A. Hazlitt, Lei Yang, Jie Fang, Tal Teitz, Justine D. Bonga, Taosheng Chen, Jian Zuo, Asli N. Goktug, Duane G. Currier, Zoran Rankovic, Shiyong Diao, Luigi I. Iconaru, Jaeki Min
Publikováno v:
Journal of Medicinal Chemistry. 61:7700-7709
There are currently no FDA-approved therapies to prevent the hearing loss associated with the usage of cisplatin in chemotherapeutic regimens. We recently demonstrated that the pharmacologic inhibition with kenpaullone or genetic deletion of CDK2 pre
Publikováno v:
Journal of Medicinal Chemistry. 61:5512-5524
Cisplatin is a highly effective treatment for malignant cancers and has become a cornerstone in chemotherapeutic regimens. Unfortunately, its use in the clinic is often coupled with a high incidence of severe hearing loss. Over the past few decades,
Autor:
Sarath Vijayakumar, Zoran Rankovic, Jaeki Min, Marisa Zallocchi, Santanu Hati, Yuju Li, Jian Zuo, Sándor Lovas, Robert A. Hazlitt
Publikováno v:
Eur J Med Chem
Cyclin-dependent kinase 2 (CDK2) is a potential therapeutic target for the treatment of hearing loss and cancer. Previously, we identified AZD5438 and AT7519-7 as potent inhibitors of CDK2, however, they also targeted additional kinases, leading to u
Publikováno v:
ChemMedChem. 12:1481-1490
The success of fluorinated molecules in drug design has led medicinal chemists to search for new fluorine-containing substituents. A major recently developed group is the pentafluorosulfanyl group. This group is stable under physiological conditions
Publikováno v:
J Org Chem
2,2,4,4,4-Pentafluoro-3,3-dihydroxyketones are valuable precursors to difluoroenolates, following fragmentation during the release of trifluoroacetate; however, there are few synthetic strategies to prepare this unique class of compound. We have addr
Publikováno v:
Journal of Medicinal Chemistry
Cisplatin is a highly effective treatment for malignant cancers and has become a cornerstone in chemotherapeutic regimens. Unfortunately, its use in the clinic is often coupled with a high incidence of severe hearing loss. Over the past few decades,
Autor:
Jie Fang, R. Kiplin Guy, Robert A. Hazlitt, Robyn A. Umans, Burgess B. Freeman, Junmin Peng, Jaeki Min, Cheng Cheng, Asli N. Goktug, Duane G. Currier, Richard W. Kriwacki, Shiyong Diao, Luigi I. Iconaru, Marie Morfouace, Justine D. Bonga, Jian Zuo, Martine F. Roussel, Michael R. Taylor, Yinmei Zhou, Tal Teitz, Taosheng Chen
Publikováno v:
The Journal of Experimental Medicine
Using a high-throughput small molecule screen, Teitz et al. identify kenpaullone, a cyclin-dependent kinase 2 inhibitor, which when delivered locally confers protection against cisplatin- and noise-induced hearing loss in zebrafish, mice, and rats an
Publikováno v:
Tetrahedron Letters. 57:1906-1908
Pentafluoro-gem-diols are substrates that enable the synthesis of valuable difluoromethylene-containing organic molecules through the release of trifluoroacetate. Currently, only one synthetic strategy is available to assemble these important precurs
Publikováno v:
Tetrahedron letters. 58(5)
Deuterodifluoromethyl ketones and sulfones were assembled in three synthetic steps from methyl ketones and sulfones, respectively. The key synthetic transformation is the deuteration of the difluorocarbanion generated by the release of trifluoroaceta
Publikováno v:
Synthesis. 47(2)
Disubstituted hydroxylamines were synthesized and used to form aluminum–amide complexes. These reagents masked carbonyl groups in situ from nucleophilic addition. The stability and utility of the aluminum–aminals are presented in the context of s