Zobrazeno 1 - 10
of 3 188
pro vyhledávání: '"Robert A. Harris"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Thioflavin-T (THT) is a common and indispensable tool for the study of amyloid pathologies and protein aggregation, both in vitro and for histological samples. In this study we expand the use of THT beyond its canonical usage for staining am
Externí odkaz:
https://doaj.org/article/1f7bb5944dd44f0db46f868c0222d40c
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Microbes have been suspected to cause Alzheimer’s disease since at least 1908, but this has generally remained unpopular in comparison to the amyloid hypothesis and the dominance of Aβ and Tau. However, evidence has been accumulating to suggest th
Externí odkaz:
https://doaj.org/article/164b317cab8c4290a00fa01e8ff883c8
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
The pathophysiology of ALS involves many signs of a disruption in copper homeostasis, with both excess free levels and functional deficiency likely occurring simultaneously. This is crucial, as many important physiological functions are performed by
Externí odkaz:
https://doaj.org/article/62850bcf9c174f978d99f277e6a30573
Autor:
Seungwon An, Balachandar Nedumaran, Hong Koh, Dong Jin Joo, Hyungjo Lee, Chul-Seung Park, Robert A. Harris, Keong Sub Shin, Ali R. Djalilian, Yong Deuk Kim
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 7, Pp 1556-1569 (2023)
Abstract Melatonin is involved in the regulation of various biological functions. Here, we explored a novel molecular mechanism by which the melatonin-induced sestrin2 (SESN2)-small heterodimer partner (SHP) signaling pathway protects against fasting
Externí odkaz:
https://doaj.org/article/ec0700fedd614f35a163c6cf6050fdd6
Autor:
Themis Thoudam, Dipanjan Chanda, Jung Yi Lee, Min-Kyo Jung, Ibotombi Singh Sinam, Byung-Gyu Kim, Bo-Yoon Park, Woong Hee Kwon, Hyo-Jeong Kim, Myeongjin Kim, Chae Won Lim, Hoyul Lee, Yang Hoon Huh, Caroline A. Miller, Romil Saxena, Nicholas J. Skill, Nazmul Huda, Praveen Kusumanchi, Jing Ma, Zhihong Yang, Min-Ji Kim, Ji Young Mun, Robert A. Harris, Jae-Han Jeon, Suthat Liangpunsakul, In-Kyu Lee
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Ca2+ overload-induced mitochondrial dysfunction is considered a contributing factor alcohol-associated liver disease pathogenesis. Here the authors report that PDK4 promotes Ca2 + -channelling complex formation at the endoplasmic reticulum-mitochondr
Externí odkaz:
https://doaj.org/article/ca818281f2e2456cb8d5bb15f28a64a9
Publikováno v:
Cell Transplantation, Vol 32 (2023)
Cell therapy is an integral modality of regenerative medicine. Macrophages are known for their sensitivity to activation stimuli and capability to recruit other immune cells to the sites of injury and healing. In addition, the route of administration
Externí odkaz:
https://doaj.org/article/e09923497bc74ae4b16f66d387f56c69
Autor:
Jingdian Zhang, Camilla Koolmeister, Jinming Han, Roberta Filograna, Leo Hanke, Monika Àdori, Daniel J. Sheward, Sina Teifel, Shreekara Gopalakrishna, Qiuya Shao, Yong Liu, Keying Zhu, Robert A. Harris, Gerald McInerney, Ben Murrell, Mike Aoun, Liselotte Bäckdahl, Rikard Holmdahl, Marcin Pekalski, Anna Wedell, Martin Engvall, Anna Wredenberg, Gunilla B. Karlsson Hedestam, Xaquin Castro Dopico, Joanna Rorbach
Publikováno v:
JCI Insight, Vol 8, Iss 17 (2023)
Pathogenic mutations in mitochondrial (mt) tRNA genes that compromise oxidative phosphorylation (OXPHOS) exhibit heteroplasmy and cause a range of multisyndromic conditions. Although mitochondrial disease patients are known to suffer from abnormal im
Externí odkaz:
https://doaj.org/article/06ca1318ae034d2c89248663f7d9045f
Autor:
Hoyul Lee, Jae Han Jeon, Yu-Jeong Lee, Mi-Jin Kim, Woong Hee Kwon, Dipanjan Chanda, Themis Thoudam, Haushabhau S. Pagire, Suvarna H. Pagire, Jin Hee Ahn, Robert A. Harris, Eun Soo Kim, In-Kyu Lee
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 2, Pp 439-461 (2023)
Background & Aims: Despite recent evidence supporting the metabolic plasticity of CD4+ T cells, it is uncertain whether the metabolic checkpoint pyruvate dehydrogenase kinase (PDK) in T cells plays a role in the pathogenesis of colitis. Methods: To i
Externí odkaz:
https://doaj.org/article/56b0f5c5afd64696a6533f36bb60da13
Autor:
Kai Zhou, Jinming Han, Harald Lund, Nageswara Rao Boggavarapu, Volker M Lauschke, Shinobu Goto, Huaitao Cheng, Yuyu Wang, Asuka Tachi, Cuicui Xie, Keying Zhu, Ying Sun, Ahmed M. Osman, Dong Liang, Wei Han, Kristina Gemzell-Danielsson, Christer Betsholtz, Xing-Mei Zhang, Changlian Zhu, Martin Enge, Bertrand Joseph, Robert A. Harris, Klas Blomgren
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-18 (2022)
Abstract Background Fluorescent reporter labeling and promoter-driven Cre-recombinant technologies have facilitated cellular investigations of physiological and pathological processes, including the widespread use of the Cx3cr1 CreER-Eyfp/wt mouse st
Externí odkaz:
https://doaj.org/article/add60eceb8c54a998f2ff155de0cb934
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-11 (2021)
Abstract There are inherent structural and functional differences in the central nervous systems (CNS) of females and males. It has been gradually established that these sex-specific differences are due to a spectrum of genetic, epigenetic, and hormo
Externí odkaz:
https://doaj.org/article/41eabea3dbcc45dcbf05c778aed58927