Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Robert A. H. van de Ven"'
Autor:
Robert A. H. van de Ven, Milou Tenhagen, Wouter Meuleman, Jeske J. G. van Riel, Ron C. J. Schackmann, Patrick W. B. Derksen
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 4, Pp 373-384 (2015)
E-cadherin inactivation underpins the progression of invasive lobular breast carcinoma (ILC). In ILC, p120-catenin (p120) translocates to the cytosol where it controls anchorage independence through the Rho-Rock signaling pathway, a key mechanism dri
Externí odkaz:
https://doaj.org/article/b7bbaceb3afd41468abf0fd1753b7c88
Autor:
Robert A. H. van de Ven, Jolien S. de Groot, Danielle Park, Robert van Domselaar, Danielle de Jong, Karoly Szuhai, Elsken van der Wall, Oscar M. Rueda, H. Raza Ali, Carlos Caldas, Paul J. van Diest, Martin W. Hetzer, Erik Sahai, Patrick W. B. Derksen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications 7: Article number: 13874 (2016); Published 22 December 2016; Updated 6 September 2017 The financial support for this Article was not fully acknowledged. The Acknowledgements should have included the National Institutes of Health
Externí odkaz:
https://doaj.org/article/146b7d7566bb4d11a0d25bc73322993b
Autor:
Sarah A. Tucker, Giulia Notarangelo, Clary B. Clish, Haejin Yoon, Robert A. H. van de Ven, Mathew T. Chvasta, Gaëlle Laurent, Jessica B. Spinelli, Elizabeth R. Nunn, Marcia C. Haigis, Shakchhi Joshi, Stacy Mulei, Krystle Kalafut, Suganja Sivaloganathan, Paulina Keskinidis, Elma Zaganjor
Publikováno v:
Cell Reports, Vol 36, Iss 2, Pp 109345-(2021)
Cell Rep
Cell Rep
Summary: Upon nutrient stimulation, pre-adipocytes undergo differentiation to transform into mature adipocytes capable of storing nutrients as fat. We profiled cellular metabolite consumption to identify early metabolic drivers of adipocyte different
Autor:
Jeroen F Vermeulen, Robert A H van de Ven, Cigdem Ercan, Petra van der Groep, Elsken van der Wall, Peter Bult, Matthias Christgen, Ulrich Lehmann, Juliet Daniel, Paul J van Diest, Patrick W B Derksen
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37864 (2012)
Kaiso is a BTB/POZ transcription factor that is ubiquitously expressed in multiple cell types and functions as a transcriptional repressor and activator. Little is known about Kaiso expression and localization in breast cancer. Here, we have related
Externí odkaz:
https://doaj.org/article/40131f4f53244a949fedd5d60232922f
Autor:
Lydia W.S. Finley, Amey Barakat, Gaudenz Danuser, Karina N. Gonzalez Herrera, Isaac S. Harris, Joris J. P. G. Demmers, Elma Zaganjor, Robert A. H. van de Ven, Marcia C. Haigis, Seung Min Jeong, Yin P Hung, Mei Rosa Ng, Jaewon J. Lee, Sandra S. McAllister
Publikováno v:
Proceedings of the National Academy of Sciences. 115:7057-7062
Metastasis remains the leading cause of cancer mortality, and reactive oxygen species (ROS) signaling promotes the metastatic cascade. However, the molecular pathways that control ROS signaling relevant to metastasis are little studied. Here, we iden
Autor:
Blessing Bassey-Archibong, Stephen J. Pettitt, Christopher J. Lord, Juliet M. Daniel, Sridevi Jaksani, Francois Richard, Thijs Koorman, Max Ratze, Rebecca Steele, Robert A. H. van de Ven, Christine Desmedt, Lotte Enserink, Clare M. Isacke, Elvira R M Bakker, Andrew Tutt, Paul J. van Diest, Thijmen Sijnesael, Patrick W. B. Derksen, Daan Visser, Amanda Fitzpatrick
Publikováno v:
Cancer Research. 81:LB246-LB246
Invasive lobular breast carcinoma (ILC) is a low grade and mostly chemo-refractory luminal-type breast cancer that has been linked to sustained proliferative quiescence and long-term latency relapses (15-20 years). Loss of E-cadherin causes metastati
Publikováno v:
Journal of Cell Science, 131(16). Company of Biologists Ltd
Journal of Cell Science
Journal of Cell Science
Metastatic breast cancer is responsible for most breast cancer-related deaths. Disseminated cancer cells have developed an intrinsic ability to resist anchorage-dependent apoptosis (anoikis). Anoikis is caused by the absence of cellular adhesion, a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2300d816e0cf67102fa45ea2382aad3
https://dspace.library.uu.nl/handle/1874/374257
https://dspace.library.uu.nl/handle/1874/374257
Publikováno v:
Small GTPases. 11(2)
Local modulation of the actin cytoskeleton is essential for the initiation and maintenance of strong homotypic adhesive interfaces between neighboring cells. The epithelial adherens junction (AJ) fulfils a central role in this process by mediating E-
Mitochondrial sirtuins (SIRT3–5) are part of the sirtuin family of NAD+ dependent deacylases and ADP ribosyl transferases. While mitochondrial sirtuins have been the focus of research for the last decades, many aspects of sirtuin biology remain unk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca2ec2ed6ae3eb9433704f9a2613dec6
https://doi.org/10.1016/b978-0-12-813499-3.00008-3
https://doi.org/10.1016/b978-0-12-813499-3.00008-3
Advancing age is the major risk factor for the development of chronic diseases and is accompanied by changes in metabolic processes and mitochondrial dysfunction. Mitochondrial sirtuins (SIRT3–5) are part of the sirtuin family of NAD + -dependent d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd9ed2a4d09caa923751e7ef8623e78
https://europepmc.org/articles/PMC5713479/
https://europepmc.org/articles/PMC5713479/