Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Robert A. Galemmo"'
Autor:
Shantasia Thomas, Benjamin Y. Owusu, James W. Janetka, Zhenfu Han, Phanindra K. M. Venukadasula, Robert A. Galemmo, Lidija Klampfer
Publikováno v:
Oncotarget
// Benjamin Y. Owusu 1 , Shantasia Thomas 1 , Phanindra Venukadasula 1 , Zhenfu Han 2 , James W. Janetka 2 , Robert A. Galemmo Jr 1 and Lidija Klampfer 1 1 Department of Oncology Southern Research, Birmingham, AL, 35205 USA 2 Department of Biochemist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::824d839fa59b86b010c16850dc287f26
https://doi.org/10.18632/oncotarget.18260
https://doi.org/10.18632/oncotarget.18260
Autor:
Benjamin Y. Owusu, Troy E. Messick, Namita Bansal, Robert A. Galemmo, Larry J. Ross, Sanjay Goel, Phanindra K. M. Venukadasula, Lidija Klampfer
Publikováno v:
Oncotarget
The binding of hepatocyte growth factor (HGF) to its receptor MET activates a signaling cascade that promotes cell survival, proliferation, cell scattering, migration and invasion of malignant cells. HGF is secreted by cancer cells or by tumor-associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::610d9f8724173a771046f6843dbb4eea
https://doi.org/10.18632/oncotarget.8785
https://doi.org/10.18632/oncotarget.8785
Autor:
James W. Janetka, Robert A. Galemmo
Publikováno v:
Extracellular Targeting of Cell Signaling in Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be280a5f664d33c1b86436e58c9443e9
https://doi.org/10.1002/9781119300229.ch9
https://doi.org/10.1002/9781119300229.ch9
Autor:
John P. Anderson, Dean R. Artis, Hing L. Sham, Roy K. Hom, Michael S. Dappen, Andrei W. Konradi, Simeon Bowers, Hu Pan, Robert A. Galemmo, Marc Adler, Pearl Tanaka, May Lin, Jeanne Baker, Lany Ruslim, Donald J. Fauss, Zhao Ren, Yong L. Zhu, Anh P. Truong, Danny Tam, Marcelle Bergeron, Lee H. Latimer, Paul Beroza, Jacek Jagodzinski, Heather Zhang, Michael P. Bova, George Tonn, Linnea Diep, Ruth Motter, Kent Fitzgerald, Nanhua Yao, Wayman Chan, Jennifer K. Hoffman, R. Jeffrey Neitz, Danielle L. Aubele
Publikováno v:
ChemMedChem. 8:1295-1313
Polo-like kinase-2 (Plk-2) has been implicated as the dominant kinase involved in the phosphorylation of α-synuclein in Lewy bodies, which are one of the hallmarks of Parkinson's disease neuropathology. Potent, selective, brain-penetrant inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9de472a2de2bc218c1224fe31845aba
https://doi.org/10.1002/cmdc.201300166
https://doi.org/10.1002/cmdc.201300166
Autor:
Roy K. Hom, Hing L. Sham, Kyle Powell, Gary Probst, Irene Griswold-Prenner, Simeon Bowers, Brian T. Peterson, Heather Zhang, Gergely Tóth, Frederique Bard, Jennifer Sealy, Karina Wong, Wayman Chan, May Lin, R. Jeffrey Neitz, Lany Ruslim, Bhushan Samant, David A. Quincy, Anh P. Truong, Robert A. Galemmo, Colin Lorentzen, Zhao Ren, Andrei W. Konradi, Mark Dryer, Wes Zmolek, Ted Yednock, Nanhua Yao, Erich Goldbach, Sarah J Wright, Hu Pan, Kevin P. Quinn, John-Michael Sauer, Dean R. Artis, George Tonn, Linda Chen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5521-5527
The SAR of a series of brain penetrant, trisubstituted thiophene based JNK inhibitors with improved pharmacokinetic properties is described. These compounds were designed based on information derived from metabolite identification studies which led t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b679a372a052f80d8da68c92b9b5f4
https://doi.org/10.1016/j.bmcl.2011.06.100
https://doi.org/10.1016/j.bmcl.2011.06.100
Autor:
Hing L. Sham, Gergley Tóth, Karina Wong, Ann Qin, Kyle Powell, David A. Quincy, Andrei W. Konradi, Nanhua Yao, Jennifer Sealy, David Chereau, Lany Ruslim, Gary Probst, Sarah J Wright, May Lin, Ted Yednock, Irene Griswold-Prenner, Wes Zmolek, Kevin P. Quinn, Hu Pan, Roy K. Hom, Simeon Bowers, Colin Lorentzen, Frederique Bard, John P. Anderson, Anh P. Truong, Zhao Ren, Robert A. Galemmo, John-Michael Sauer, Dean R. Artis, David F. Nakamura
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:315-319
In this Letter, we describe the discovery of selective JNK2 and JNK3 inhibitors, such as 10, that routinely exhibit >10-fold selectivity over JNK1 and >1000-fold selectivity over related MAPKs, p38α and ERK2. Substitution of the naphthalene ring aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a612c27c0d960510e5c57743328c54cf
https://doi.org/10.1016/j.bmcl.2010.11.010
https://doi.org/10.1016/j.bmcl.2010.11.010
Autor:
Ehab Khalil, Anna C. Maroney, Kevin J. Moriarty, Farah Ali, Robert A. Galemmo, Dana L. Johnson, Carl S. Crysler, Holly K. Koblish, Ioanna P. Petrounia, Thomas Garrabrant, Jahanvi Maisuria
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5778-5783
A new class of Aurora-A inhibitors have been identified based on the 2-amino-pyrrolo[2,3-d]pyrimidine scaffold. Here, we describe the synthesis and SAR of this novel series. We report compounds which exhibit nanomolar activity in the Aurora-A biochem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb0c0dd5ff5427ffd7e6d4e32438f0c
https://doi.org/10.1016/j.bmcl.2006.08.080
https://doi.org/10.1016/j.bmcl.2006.08.080
Autor:
Holly K. Koblish, John A. Masucci, Juan J. Marugan, Ludmila A. Barnakova, Anna C. Maroney, Larry E. Weaner, Dana L. Johnson, Thomas Garrabrant, Tara M. Mezzasalma, Alexander N. Barnakov, William J. Jones, Robert A. Galemmo, Matthew J. Todd, Ingrid Deckman
Publikováno v:
Biochemistry. 45:5678-5685
Heat shock protein 90 (Hsp90) is critical for the maturation of numerous client proteins, many of which are involved in cellular transformation and oncogenesis. The ansamycins, geldanamycin (GA) and its derivative, 17-allylaminogeldanamycin (17-AAG),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06546c539091ed34960b0bc2819af574
https://doi.org/10.1021/bi0524969
https://doi.org/10.1021/bi0524969
Publikováno v:
Molecular Cancer Therapeutics. 4:1198-1204
With the advent of agents directed against specific molecular targets in drug discovery, it has become imperative to show a compound's cellular impact on the intended biomolecule in vivo. The objective of the present study was to determine if we coul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad7f8842c8a045d465cf1fc9d8f9411
https://doi.org/10.1158/1535-7163.mct-05-0004
https://doi.org/10.1158/1535-7163.mct-05-0004
Autor:
Bruce P. Damiano, Dana L. Johnson, Shyamali Ghosh, Brunner Livia, Brett A. Tounge, Jef C. Proost, William J. Hoekstra, Judith Baker, Robert A. Galemmo, Rosemary J. Santulli, Bruce E. Maryanoff, Candace Burns, William A. Kinney, Corte Bart De, Liu Li, Robert W. Tuman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:5227-5232
The synthesis and SAR of a new class of piperidine-based αvβ3/αvβ5 integrin antagonists is described. Replacement of an amide bond in a prototype isonipecotamide by a C–C isostere, and adjustment of the spacer length between the carboxylic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::331e139a8252211e93d606ef30ad5fd8
https://doi.org/10.1016/j.bmcl.2004.06.061
https://doi.org/10.1016/j.bmcl.2004.06.061