Zobrazeno 1 - 10
of 444
pro vyhledávání: '"Robert A. Cross"'
Autor:
Yean Ming Chew, Robert A. Cross
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract Taxol is a small molecule effector that allosterically locks tubulin into the microtubule lattice. We show here that taxol has different effects on different single-isotype microtubule lattices. Using in vitro reconstitution, we demonstrate
Externí odkaz:
https://doaj.org/article/c66b6eabede4475daaa507fc7552cd28
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
In vitro kinesin-coated gold nanorod (kinesin-GNRs) assays reveal that torque drives both rolling and yawing of kinesin-GNRs translocating along the microtubule axis with possible relevance to intracellular transport.
Externí odkaz:
https://doaj.org/article/6c665d0309dd48d8acfdca0ba33704a8
Publikováno v:
Biology Open, Vol 1, Iss 1, Pp 12-18 (2011)
Summary Roughly half of all animal somatic cell spindles assemble by the classical prophase pathway, in which the centrosomes separate ahead of nuclear envelope breakdown (NEBD). The remainder assemble by the prometaphase pathway, in which the centro
Externí odkaz:
https://doaj.org/article/8caf8d714b70438688c73618c26e7007
Autor:
Courtney Woolsey, Robert W. Cross, Abhishek N. Prasad, Krystle N. Agans, Viktoriya Borisevich, Daniel J. Deer, Natalie S. Dobias, Alyssa C. Fears, Mack B. Harrison, Megan L. Heinrich, Karla A. Fenton, Robert F. Garry, Luis M. Branco, Thomas W. Geisbert
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
ABSTRACTLassa virus (LASV) is a World Health Organization (WHO) priority pathogen that causes high morbidity and mortality. Recently, we showed that a combination of three broadly neutralizing human monoclonal antibodies known as Arevirumab-3 (8.9F,
Externí odkaz:
https://doaj.org/article/055f26a5860147ff8cc66a9db9b3c6b4
Autor:
Courtney Woolsey, Alyssa C. Fears, Viktoriya Borisevich, Krystle N. Agans, Natalie S. Dobias, Abhishek N. Prasad, Daniel J. Deer, Joan B. Geisbert, Karla A. Fenton, Thomas W. Geisbert, Robert W. Cross
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 1635-1646 (2022)
Due to its high mortality rate and continued re-emergence, Ebolavirus disease (EVD) continues to pose a serious threat to global health. A group of viruses within the genus Ebolavirus causes this severe hemorrhagic disease in humans: Ebola virus (EBO
Externí odkaz:
https://doaj.org/article/4ba14efe32f140fb83a7c614da4e3f7b
Autor:
Robert W. Cross, Christopher M. Wiethoff, Patricia Brown-Augsburger, Shawn Berens, Jamie Blackbourne, Ling Liu, Xiaohua Wu, Jonathan Tetreault, Carter Dodd, Ramtin Sina, Derrick R. Witcher, Deanna Newcomb, Denzil Frost, Angela Wilcox, Viktoriya Borisevich, Krystle N. Agans, Courtney Woolsey, Abhishek N. Prasad, Daniel J. Deer, Joan B. Geisbert, Natalie S. Dobias, Karla A. Fenton, Beth Strifler, Philip Ebert, Richard Higgs, Anne Beall, Sumit Chanda, Laura Riva, Xin Yin, Thomas W. Geisbert
Publikováno v:
Pathogens, Vol 12, Iss 12, p 1408 (2023)
As part of the non-clinical safety package characterizing bamlanivimab (SARS-CoV-2 neutralizing monoclonal antibody), the risk profile for antibody-dependent enhancement of infection (ADE) was evaluated in vitro and in an African green monkey (AGM) m
Externí odkaz:
https://doaj.org/article/f7f4761387234185a8923bd4c6b15ef6
Autor:
Teresa E. Sorvillo, Robert W. Cross, Dylan M. Johnson, Natalie S. Dobias, Karla A. Fenton, Chad E. Mire, Thomas W. Geisbert
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-8 (2021)
Abstract Junin virus (JUNV) is a pathogen of biodefense importance due to its potential for aerosol transmission and mortality rates reaching 30%. Currently, there are no JUNV vaccines licensed by the United States Food and Drug Administration (FDA)
Externí odkaz:
https://doaj.org/article/713abba0383a49a4b2dc963289c7e778
Autor:
Courtney Woolsey, Robert W Cross, Krystle N Agans, Viktoriya Borisevich, Daniel J Deer, Joan B Geisbert, Cheryl Gerardi, Theresa E Latham, Karla A Fenton, Michael A Egan, John H Eldridge, Thomas W Geisbert, Demetrius Matassov
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 5, p e0010433 (2022)
BackgroundMarburg virus (MARV), an Ebola-like virus, remains an eminent threat to public health as demonstrated by its high associated mortality rate (23-90%) and recent emergence in West Africa for the first time. Although a recombinant vesicular st
Externí odkaz:
https://doaj.org/article/03f5f518f8bc426ba64de4f125e7cfd9
Autor:
Kathryn Westendorf, Stefanie Žentelis, Lingshu Wang, Denisa Foster, Peter Vaillancourt, Matthew Wiggin, Erica Lovett, Robin van der Lee, Jörg Hendle, Anna Pustilnik, J. Michael Sauder, Lucas Kraft, Yuri Hwang, Robert W. Siegel, Jinbiao Chen, Beverly A. Heinz, Richard E. Higgs, Nicole L. Kallewaard, Kevin Jepson, Rodrigo Goya, Maia A. Smith, David W. Collins, Davide Pellacani, Ping Xiang, Valentine de Puyraimond, Marketa Ricicova, Lindsay Devorkin, Caitlin Pritchard, Aoise O’Neill, Kush Dalal, Pankaj Panwar, Harveer Dhupar, Fabian A. Garces, Courtney A. Cohen, John M. Dye, Kathleen E. Huie, Catherine V. Badger, Darwyn Kobasa, Jonathan Audet, Joshua J. Freitas, Saleema Hassanali, Ina Hughes, Luis Munoz, Holly C. Palma, Bharathi Ramamurthy, Robert W. Cross, Thomas W. Geisbert, Vineet Menachery, Kumari Lokugamage, Viktoriya Borisevich, Iliana Lanz, Lisa Anderson, Payal Sipahimalani, Kizzmekia S. Corbett, Eun Sung Yang, Yi Zhang, Wei Shi, Tongqing Zhou, Misook Choe, John Misasi, Peter D. Kwong, Nancy J. Sullivan, Barney S. Graham, Tara L. Fernandez, Carl L. Hansen, Ester Falconer, John R. Mascola, Bryan E. Jones, Bryan C. Barnhart
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110812- (2022)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing monoclonal antibodies (mAbs) can reduce the risk of hospitalization from coronavirus disease 2019 (COVID-19) when administered early. However, SARS-CoV-2 variants of c
Externí odkaz:
https://doaj.org/article/daeff3ff2f814504a3643f35bb419fcf
Autor:
Robert W. Cross, Zachary A. Bornholdt, Abhishek N. Prasad, Viktoriya Borisevich, Krystle N. Agans, Daniel J. Deer, Dafna M. Abelson, Do H. Kim, William S. Shestowsky, Lioudmila A. Campbell, Elaine Bunyan, Joan B. Geisbert, Karla A. Fenton, Larry Zeitlin, Danielle P. Porter, Thomas W. Geisbert
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Extending the therapeutic window for acute viral infections could save lives. Here, the authors show that combination treatment with a human monoclonal antibody and remdesivir initiated at 6 days post infection with Marburg virus provides 80% protect
Externí odkaz:
https://doaj.org/article/d0f0bff00c684416a81ac789aecee0a8