Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Robert A. Coover"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 371 (2024)
Neurofibromatosis Type 1 (NF1) is a common neurogenic condition characterized by heterozygous loss of function mutations in the neurofibromin gene. NF1 patients are susceptible to the development of neurofibromas, including plexiform neurofibromas (p
Externí odkaz:
https://doaj.org/article/4c8e457f923f41c38b1827e9a7fcd4a3
Autor:
Robert A. Coover, Tabitha E. Healy, Li Guo, Katherine E. Chaney, Robert F. Hennigan, Craig S. Thomson, Lindsey E. Aschbacher-Smith, Michael P. Jankowski, Nancy Ratner
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-15 (2018)
Abstract Normal Schwann cells (SCs) are quiescent in adult nerves, when ATP is released from the nerve in an activity dependent manner. We find that suppressing nerve activity in adult nerves causes SC to enter the cell cycle. In vitro, ATP activates
Externí odkaz:
https://doaj.org/article/1bfa1d5d9ede4c02abd2406952f3a5c2
Autor:
Kwangmin Choi, Robert A. Coover, Nancy Ratner, Tilat A. Rizvi, Melissa R. Perrino, Katherine E. Chaney, Jay Pundavela, David A. Largaespada, Craig S. Thomson
Publikováno v:
Oncogene
Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft-tissue sarcomas that cause significant mortality in adults with Neurofibromatosis Type 1 (NF1). We compared gene expression of growth factors in normal human nerves to MPNST and nor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72f552363c255a405fa98cecbacaabfe
https://doi.org/10.1038/s41388-021-01773-x
https://doi.org/10.1038/s41388-021-01773-x
Autor:
Garrett Alewine, Jerrica Knight, Adithya Ghantae, Christina Mamrega, Bashnona Attiah, Robert A. Coover, Cale D. Fahrenholtz
Publikováno v:
Journal of Personalized Medicine; Volume 12; Issue 7; Pages: 1080
Neurofibromatosis type 1 (NF1) is among the most common neurogenic disorders, characterized by loss of function mutations in the neurofibromin gene (NF1). NF1 patients are extremely susceptible to developing neurofibromas, which can transform into de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd2268137255a0d4c67a8269be79b37
https://pubmed.ncbi.nlm.nih.gov/35887576
https://pubmed.ncbi.nlm.nih.gov/35887576
Publikováno v:
Glia
To facilitate analyses of purinergic signaling in peripheral nerve glia, we review recent literature and catalog purinergic receptor mRNA expression in cultured mouse Schwann cells (SCs). Purinergic signaling can decrease developmental SC proliferati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ed79299d96d476a31b9dacbb788098
https://doi.org/10.1002/glia.23969
https://doi.org/10.1002/glia.23969
Autor:
Jennifer Patritti Cram, Jianqiang Wu, Robert A Coover, Tilat A Rizvi, Katherine E Chaney, Ramya Ravindran, Jose A Cancelas, Robert J Spinner, Nancy Ratner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1086bbc5c6891bffc248e8f3aec5f0ca
https://doi.org/10.7554/elife.73511.sa2
https://doi.org/10.7554/elife.73511.sa2
Publikováno v:
Cureus
Background and objective Neurofibromatosis 1 (NF1) is a genetic disorder that is accompanied by psychiatric comorbidities such as depression, anxiety, and attention-deficit hyperactivity disorder (ADHD) in more than half of the patients. However, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::594c93eae217115ad7840848ffa76395
https://doi.org/10.7759/cureus.20244
https://doi.org/10.7759/cureus.20244
Autor:
Robert J. Spinner, Jennifer Patritti-Cram, Katherine E. Chaney, Shinji Kuninaka, Jose A. Cancelas, Jianqiang Wu, Robert F. Hennigan, Tilat A. Rizvi, Robert A. Coover, Ramya Ravindran, Nancy Ratner
Neurofibromatosis type 1 (NF1) is a genetic disorder characterized by nerve tumors called neurofibromas, in which Schwann cells (SCs) lack NF1 and show deregulated RAS signaling. NF1 is also implicated in regulation of cAMP. Gene expression profiling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ece2c5eedcfa53c2a480999cdb4b267
https://doi.org/10.1101/2021.09.24.461701
https://doi.org/10.1101/2021.09.24.461701
Autor:
Jennifer Patritti Cram, Jianqiang Wu, Robert A Coover, Tilat A Rizvi, Katherine E Chaney, Ramya Ravindran, Jose A Cancelas, Robert J Spinner, Nancy Ratner
Publikováno v:
eLife. 11
Neurofibromatosis type 1 (NF1) is characterized by nerve tumors called neurofibromas, in which Schwann cells (SCs) show deregulated RAS signaling. NF1 is also implicated in regulation of cAMP. We identified the G-protein-coupled receptor (GPCR) P2ry1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b83042ad02a15e288c90e827d74fc4
https://pubmed.ncbi.nlm.nih.gov/35311647
https://pubmed.ncbi.nlm.nih.gov/35311647
Autor:
Garrett Alewine, Adithya Ghantae, Christina Mamrega, Jerrica L. Knight, Bashnona Attiah, Robert A. Coover, Cale D. Fahrenholtz
Publikováno v:
Cancer Research. 82:373-373
Neurofibromatosis type 1 (NF1) is the most common neurogenic disorder affecting 1 in every 3,000 people worldwide. NF1 is defined by heterozygous loss-of-function of the neurofibromin 1 gene (NF1). NF1 patients develop neurofibromas with near complet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb18e84e0939293091264c94f0451a1b
https://doi.org/10.1158/1538-7445.am2022-373
https://doi.org/10.1158/1538-7445.am2022-373