Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Robert A. Conradi"'
Autor:
Brian J. Stockman, Terrence A. Scahill, Philip S. Burton, Robert A. Conradi, Jay T. Goodwin, James R. Blinn, David A. Kloosterman
Publikováno v:
Biopolymers. 53:396-410
Efficient transport of intact drug (solute) across the intestinal epithelium is typically a requirement for good oral activity. In general, the membrane permeability of a solute is a complex function of its size, lipophilicity, hydrogen bond potentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d8f36ac4994e6471f945b0262301239
https://doi.org/10.1002/(sici)1097-0282(20000415)53:5<396::aid-bip4>3.0.co
https://doi.org/10.1002/(sici)1097-0282(20000415)53:5<396::aid-bip4>3.0.co
Publikováno v:
The Journal of Peptide Research. 53:355-369
The therapeutic efficacy of an orally administered drug is dictated not only by its pharmacological properties such as potency and selectivity, but also its pharmacokinetic properties such as its access to the site of activity. Thorough evaluation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c68b6b4bfeda72deb48a5fb389b5cd
https://doi.org/10.1034/j.1399-3011.1999.00072.x
https://doi.org/10.1034/j.1399-3011.1999.00072.x
Autor:
Ford Charles W, Robert A. Conradi, Jenifer L. Adamski, Randy M. Jensen, Debra A. Allwine, Barbachyn Michael R, John A. Tucker, Gary E. Zurenko, Jennifer L. Klock, Hutchinson Douglas K, Steven J. Brickner, Phillip S. Burton, Kevin C. Grega
Publikováno v:
Journal of Medicinal Chemistry. 41:3727-3735
Oxazolidinones are a novel class of synthetic antibacterial agents active against gram-positive organisms including methicillin-resistant Staphylococcus aureus as well as selected anaerobic organisms. Important representatives of this class include t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d34a88e0c2051e1805ace7c6383cf0a9
https://doi.org/10.1021/jm980274l
https://doi.org/10.1021/jm980274l
Publikováno v:
Advanced Drug Delivery Reviews. 23:143-156
Cellular efflux pathways function to remove both endogenous and exogenous substances from the cell. In the case of a polarized cellular barrier, such as the epithelium, these pathways serve an excretory or secretory role in transporting solutes out o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54584cc8982ba18fcf2ed5ef68c1014b
https://doi.org/10.1016/s0169-409x(96)00432-2
https://doi.org/10.1016/s0169-409x(96)00432-2
Publikováno v:
QSAR & Combinatorial Science. 13:4-10
In the search for a better model of the rate limiting processes in peptide transport we studied the partitioning of solutes between heptane and ethylene glycol. Methods for determining the log partition coefficient (logPH/G) in this solvent system we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be047ea68b34c151b6db3539dc1884d2
https://doi.org/10.1002/qsar.19940130103
https://doi.org/10.1002/qsar.19940130103
Publikováno v:
Journal of Drug Targeting. 2:167-171
The influence of the aminoterminal substituent in a homologous series of tetrapeptide analogs on transport across Caco-2 cell monolayers was studied. In a series of pyridylcarboxamide regioisomers, the 2-pyridyl isomer was significantly more permeabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a49e0593b5c4e4de217972556d3e852
https://doi.org/10.3109/10611869409015906
https://doi.org/10.3109/10611869409015906
Autor:
W. J. Howe, W. T. Lowther, J. O. Hui, W. G. Tarpley, D. E. Emmert, Chetana Rao, A G Tomasselli, John H. Kinner, V. S. Bradford, D. L. Alexander, Tomi K. Sawyer, B.M. Dunna, Robert A. Conradi, D. L. Decamp, Clark W. Smith, Allen W. Harrison, Charles S. Craik, James Michael Tustin, T. J. Mcquade, Robert L. Heinrikson, Y. Z. Zhang, Philip S. Burton, Jed F. Fisher, Roger A. Poorman, Joseph B. Moon, Jackson B. Hester, D J Staples, L. Liu, P. E. Scarborough, Maggiora Linda Louise
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:819-824
The structure-activity relationships and pharmacophore modeling aspects of a series of HIV PR inhibitors modified at the N- and/or C-terminus of the dipeptide isostere ChaΨ[CH(OH)CH2]Val (Cha, cyclohexylalanine) are reported. The HIV PR binding affi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b57d250dd9d5791ff9b0e19fb8eaad6
https://doi.org/10.1016/s0960-894x(00)80673-3
https://doi.org/10.1016/s0960-894x(00)80673-3
Autor:
W. J. Howe, W. T. Lowther, A G Tomasselli, D. E. Emmert, D J Staples, Jackson B. Hester, W. G. Tarpley, J. O. Hui, Ben M. Dunn, John H. Kinner, Robert L. Heinrikson, Y. Z. Zhang, Tomi K. Sawyer, Charles S. Craik, D. L. Decamp, James Michael Tustin, T. J. Mcquade, D. L. Alexander, Allen W. Harrison, P. E. Scarborough, Robert A. Conradi, Jed F. Fisher, Roger A. Poorman, Philip S. Burton, Maggiora Linda Louise, V. S. Bradford, Joseph B. Moon, L. Liu, Clark W. Smith, Chetana Rao
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b99dbead49d3038ea527912ab65dad7
https://doi.org/10.1002/chin.199509217
https://doi.org/10.1002/chin.199509217
Publikováno v:
Journal of Controlled Release. 19:87-97
The successful development of orally bioavailable peptides and peptide-like substances as therapeutic agents will require an understanding of how structure influences absorption across the intestinal mucosa. In an attempt to define such relationships
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb6ac348343a5a4a5463957987e762b9
https://doi.org/10.1016/0168-3659(92)90067-2
https://doi.org/10.1016/0168-3659(92)90067-2
Publikováno v:
Pharmaceutical Research. :435-439
In order to study the influence of hydrogen bonding in the amide backbone of a peptide on permeability across a cell membrane, a series of tetrapeptide analogues was prepared from D-phenylalanine. The amide nitrogens in the parent oligomer were seque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92f8390e054194d6624f3bfbe49caec8
https://doi.org/10.1023/a:1015867608405
https://doi.org/10.1023/a:1015867608405