A Comparison of Magnetic Resonance Imaging Methods to Assess Multiple Sclerosis Lesions: Implications for Patient Characterization and Clinical Trial Design

Autor: Ewart Mark Haacke, Evanthia Bernitsas, Karthik Subramanian, David Utriainen, Vinay Kumar Palutla, Kiran Yerramsetty, Prashanth Kumar, Sean K. Sethi, Yongsheng Chen, Zahid Latif, Pavan Jella, Sara Gharabaghi, Ying Wang, Xiaomeng Zhang, Robert A. Comley, John Beaver, Yanping Luo

Publikováno v: Diagnostics, Vol 12, Iss 1, p 77 (2021)

Magnetic resonance imaging (MRI) is a sensitive imaging modality for identifying inflammatory and/or demyelinating lesions, which is critical for a clinical diagnosis of MS and evaluating drug responses. There are many unique means of probing brain t

Externí odkaz: https://doaj.org/article/e731727d80cb486496df63604751f7a5

Evaluation of a semi-automated approach for FDG PET image analysis for routine clinical application in patients with multiple myeloma

Autor: Tyler J Wellman, Sarah R Mudd, Kelly N Godby, Dustin W Wooten, Jeremy A Ross, Orlando F Bueno, Danielle Wanik, Chaitanya R Divgi, Robert A Comley, Luciano J Costa, Jacob Y Hesterman

Publikováno v: Translational Oncology, Vol 37, Iss , Pp 101767- (2023)

Background: FDG PET/CT is a tool for assessing response to therapy in various cancers, and may provide an earlier biomarker of clinical response. We developed a novel semi-automated approach for analyzing FDG PET/CT images in patients with multiple m

Externí odkaz: https://doaj.org/article/c0fa07e75db04630b3f8adad4bf6cb5e

Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer’s disease

Autor: Ashwin V. Venkataraman, Ayla Mansur, Gaia Rizzo, Courtney Bishop, Yvonne Lewis, Ece Kocagoncu, Anne Lingford-Hughes, Mickael Huiban, Jan Passchier, James B. Rowe, Hideo Tsukada, David J. Brooks, Laurent Martarello, Robert A. Comley, Laigao Chen, Adam J. Schwarz, Richard Hargreaves, Roger N. Gunn, Eugenii A. Rabiner, Paul M. Matthews

Publikováno v: Venkataraman, A V, Mansur, A, Rizzo, G, Bishop, C, Lewis, Y, Kocagoncu, E, Lingford-Hughes, A, Huiban, M, Passchier, J, Rowe, J B, Tsukada, H, Brooks, D J, Martarello, L, Comley, R A, Chen, L, Schwarz, A J, Hargreaves, R, Gunn, R N, Rabiner, E A & Matthews, P M 2022, ' Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer's disease ', Science Translational Medicine, vol. 14, no. 658, eabk1051 . https://doi.org/10.1126/scitranslmed.abk1051

Cell stress and impaired oxidative phosphorylation are central to mechanisms of synaptic loss and neurodegeneration in the cellular pathology of Alzheimer’s disease (AD). In this study, we quantified the in vivo expression of the endoplasmic reticu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f1dff4aaab7fcdad74b5dfc66d7a81
https://doi.org/10.1126/scitranslmed.abk1051

Test–retest variability and reference region-based quantification of 18F-BCPP-EF for imaging mitochondrial complex I in the human brain

Autor: Jan Passchier, Yvonne Lewis, Hideo Tsukada, Roger N. Gunn, Robert A. Comley, Ayla Mansur, Eugenii A. Rabiner, Mickael Huiban

Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 41:771-779

Mitochondrial complex I (MC-I) is an essential regulator of brain bioenergetics and can be quantified in the brain using PET radioligand 18F-BCPP-EF. Here we evaluate the test–retest reproducibility of 18F-BCPP-EF in humans, and assess the use of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8df8043afb128d95ef788a667fe875f2
https://doi.org/10.1177/0271678x20928149

Baseline amyloid and tau PET imaging characteristics in the ongoing phase 2 study of tilavonemab in early Alzheimer’s disease

Autor: Dustin W. Wooten, Qi Guo, Ziyi Jin, Scott Gladstein, Edwin Stage, Jacob Hesterman, Nahome Fisseha, Hana Florian, Robert A. Comley

Publikováno v: Alzheimer's & Dementia. 17

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27284de1af7839c99d9ee02e8c3bbe53
https://doi.org/10.1002/alz.052183