Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Robert A. Cerulli"'
Autor:
Charles Abakah, Jiayuan Miao, Kirsten Deprey, James D. Baleja, Adam Moyer, Bryan J. Lampkin, Jennifer R. Pace, David Baker, Yu-Shan Lin, Joshua A. Kritzer, Robert A. Cerulli
Publikováno v:
J Am Chem Soc
Peptides constrained by intramolecular cross-links, especially stapled α-helices, have emerged as versatile scaffolds for drug development. However, there are fewer examples of similarly constrained scaffolds for other secondary structures. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b2db5b75ccf8e6895ff17249aed574
https://doi.org/10.1021/jacs.1c04378
https://doi.org/10.1021/jacs.1c04378
Autor:
Joshua A. Kritzer, Jennifer R. Pace, Hawley F. Brown, Robert A. Cerulli, Livia Shehaj, Yang Mei
Publikováno v:
Chembiochem
A growing body of evidence suggests that autophagy inhibition enhances the effectiveness of chemotherapy, especially in difficult-to-treat cancers. Existing autophagy inhibitors are primarily lysosomotropic agents. More specific autophagy inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b068ef6b388b98a96f0180d799b05a7
https://doi.org/10.1002/cbic.202000212
https://doi.org/10.1002/cbic.202000212
Autor:
Joshua A. Kritzer, Robert A. Cerulli
Publikováno v:
Org Biomol Chem
Tyrosine phosphorylation is a critical component of signal transduction for multicellular organisms, particularly for pathways that regulate cell proliferation and differentiation. While tyrosine kinase inhibitors have become FDA-approved drugs, inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c281efbe62bf3ecbe5ca3165cf270c8f
https://doi.org/10.1039/c9ob01998g
https://doi.org/10.1039/c9ob01998g
Autor:
Isidora Tošić, Kevin Jiang, Jing Wang, Robert A. Cerulli, Livia Shehaj, Joshua A. Kritzer, David A. Frank
Publikováno v:
Bioorg Med Chem
The signal transducer and activator of transcription 3 (STAT3) protein is constitutively activated in several cancers. STAT3 activity can be blocked by inhibiting its Src Homology 2 (SH2) domain, but phosphotyrosine and its isosteres have poor bioava
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f31fc9e70ed273e0b05e856c4e3c7f
https://europepmc.org/articles/PMC7294595/
https://europepmc.org/articles/PMC7294595/
Autor:
Joshua A. Kritzer, Robert A. Cerulli
Publikováno v:
Biochemistry. 58:1943-1944
[Image: see text]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de5a8e79972b028210ffb01dee879bd7
https://doi.org/10.1021/acs.biochem.9b00002
https://doi.org/10.1021/acs.biochem.9b00002
Publikováno v:
Blood. 124:1772-1772
Background: Recent clinical trials have highlighted the therapeutic benefit of BTK inhibitors in lymphoma with varying degrees of activity dependent in part on morphology and genetic origin. There appears to be a proclivity of activity in activated B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a45845abf88f472001ee5829df27156
https://doi.org/10.1182/blood.v124.21.1772.1772
https://doi.org/10.1182/blood.v124.21.1772.1772