Zobrazeno 1 - 10
of 337
pro vyhledávání: '"Robert A. Brodsky"'
Autor:
Geoffrey Hall, Janet G. Markle, James Maiarana, Paul L. Martin, Jennifer A. Rothman, John W. Sleasman, Howard Lederman, Antoine E. Azar, Robert A. Brodsky, Talal Mousallem
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
A 20-year-old male patient with a history of celiac disease came to medical attention after developing profound fatigue and pancytopenia. Evaluation demonstrated pan-hypogammaglobulinemia. There was no history of significant clinical infections. Bone
Externí odkaz:
https://doaj.org/article/5324ac2bf76d46c88d830dc944e94e14
Publikováno v:
Haematologica, Vol 109, Iss 2 (2023)
Externí odkaz:
https://doaj.org/article/8e2aeacf3ba3409e8e06f60d20e8cb52
Autor:
Emmanuel K. Teye, Shasha Lu, Fangyuan Chen, Wenrui Yang, Thomas Abraham, Douglas B. Stairs, Hong-Gang Wang, Gregory S. Yochum, Robert A. Brodsky, Jeffrey J. Pu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Phosphatidylinositol glycan anchor biosynthesis class N (PIGN) has been linked to the suppression of chromosomal instability. The spindle assembly checkpoint complex is responsible for proper chromosome segregation during mitosis to prevent
Externí odkaz:
https://doaj.org/article/de2cadc6ed4e4474b1a7633bdd7d1cd8
Autor:
Austin G. Kulasekararaj, Robert A. Brodsky, Jun-ichi Nishimura, Christopher J. Patriquin, Hubert Schrezenmeier
Publikováno v:
Therapeutic Advances in Hematology, Vol 13 (2022)
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, chronic hematologic disorder associated with inappropriate terminal complement activity on blood cells that can result in intravascular hemolysis (IVH), thromboembolic events (TEs), and organ damag
Externí odkaz:
https://doaj.org/article/cbcf69a5e1e545d1bc820aa1213104fb
Autor:
Jia Yu, Gloria F. Gerber, Hang Chen, Xuan Yuan, Shruti Chaturvedi, Evan M. Braunstein, Robert A. Brodsky
Publikováno v:
Haematologica, Vol 107, Iss 5 (2021)
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may manifest as thrombosis, stroke, renal failure, myocardial infarction, and thrombocytopenia, reminiscent of other complement- mediated diseases. Multiple clinical and preclinical studies
Externí odkaz:
https://doaj.org/article/a7554fe69a974a30b503743a5dd25cc4
Autor:
Jin Y. Chen, Neeti S. Galwankar, Heather N. Emch, Smrithi S. Menon, Claudio Cortes, Joshua M. Thurman, Samuel A. Merrill, Robert A. Brodsky, Viviana P. Ferreira
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The complement system alternative pathway (AP) can be activated excessively in inflammatory diseases, particularly when there is defective complement regulation. For instance, deficiency in complement regulators CD55 and CD59, leads to paroxysmal noc
Externí odkaz:
https://doaj.org/article/a698ee5afd81457bb75e45a9b275cddc
Autor:
Jun Shen, Yaoyao Zhu, Cuicui Lyu, Zicen Feng, Shuzhen Lyu, Yuping Zhao, Dixie L. Hoyle, Guangzhen Ji, Weimin Miao, Xiaobing Zhang, Linzhao Cheng, Robert A. Brodsky, Tao Cheng, Zack Z. Wang
Publikováno v:
Haematologica, Vol 105, Iss 2 (2020)
Externí odkaz:
https://doaj.org/article/72f50708bbc845d8b871c5d216df3c1b
Autor:
Robert A. Brodsky, Régis Peffault de Latour, Scott T. Rottinghaus, Alexander Röth, Antonio M. Risitano, Ilene C. Weitz, Peter Hillmen, Jaroslaw P. Maciejewski, Jeff Szer, Jong Wook Lee, Austin G. Kulasekararaj, Lori Volles, Andrew I. Damokosh, Stephan Ortiz, Lori Shafner, Peng Liu, Anita Hill, Hubert Schrezenmeier
Publikováno v:
Haematologica, Vol 106, Iss 1 (2020)
Eculizumab is first-line treatment for paroxysmal nocturnal hemoglobinuria (PNH); however, approximately 11%-27% of patients may experience breakthrough hemolysis (BTH) on approved doses of eculizumab. Ravulizumab, a new long-acting C5 inhibitor with
Externí odkaz:
https://doaj.org/article/e3c0bd580d374332a80ee7518eb29f3a
Autor:
Isabelle Thiffault, Britton Zuccarelli, Holly Welsh, Xuan Yuan, Emily Farrow, Lee Zellmer, Neil Miller, Sarah Soden, Ahmed Abdelmoity, Robert A. Brodsky, Carol Saunders
Publikováno v:
BMC Medical Genetics, Vol 18, Iss 1, Pp 1-5 (2017)
Abstract Background Defects in the human glycosylphosphatidylinositol anchor biosynthetic pathway are associated with inherited glycosylphosphatidylinositol (GPI)-deficiencies characterized by a broad range of clinical phenotypes including multiple c
Externí odkaz:
https://doaj.org/article/62e2ea1ee7c143b8a7a53e166b7fbad7
Autor:
Yvette L. Kasamon, Richard F. Ambinder, Ephraim J. Fuchs, Marianna Zahurak, Gary L. Rosner, Javier Bolaños-Meade, Mark J. Levis, Douglas E. Gladstone, Carol Ann Huff, Lode J. Swinnen, William H. Matsui, Ivan Borrello, Robert A. Brodsky, Richard J. Jones, Leo Luznik
Publikováno v:
Blood Advances, Vol 1, Iss 4, Pp 288-292 (2017)
Abstract: Allogeneic blood or marrow transplantation (BMT) candidates may lack HLA-matched, related haploidentical, and unrelated umbilical cord options. Barriers to partially HLA-mismatched, unrelated donor (mMUD) BMT include excess graft-versus-hos
Externí odkaz:
https://doaj.org/article/af2ec2c8d00b48949c2586a19a5e7f02