Zobrazeno 1 - 10
of 316
pro vyhledávání: '"Robert A. Bridges"'
Autor:
Miki E. Verma, Robert A. Bridges, Michael D. Iannacone, Samuel C. Hollifield, Pablo Moriano, Steven C. Hespeler, Bill Kay, Frank L. Combs
Publikováno v:
PLoS ONE, Vol 19, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/33f617b3270a45bf8d01fe7fd8742cb7
Autor:
Matthew D. Strub, Shyam Ramachandran, Dmitri Y. Boudko, Ella A. Meleshkevitch, Alejandro A. Pezzulo, Aravind Subramanian, Arthur Liberzon, Robert J. Bridges, Paul B. McCray Jr.
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 2, Pp 240-251 (2022)
Abstract Cystic fibrosis (CF) is a lethal autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The common ΔF508‐CFTR mutation results in protein misfolding and proteasomal degradat
Externí odkaz:
https://doaj.org/article/118b9841113341758b26c7d71659a1be
Autor:
Rachel A. Hodos, Matthew D. Strub, Shyam Ramachandran, Ella A. Meleshkevitch, Dmitri Y. Boudko, Robert J. Bridges, Joel T. Dudley, Paul B. McCray Jr.
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 5, Pp 500-510 (2021)
Abstract Rare diseases affect 10% of the first‐world population, yet over 95% lack even a single pharmaceutical treatment. In the present age of information, we need ways to leverage our vast data and knowledge to streamline therapeutic development
Externí odkaz:
https://doaj.org/article/35af72e80c624b9c9410aa56577a0eb6
Autor:
Karen S. Raraigh, Kathleen C. Paul, Jennifer L. Goralski, Erin N. Worthington, Anna V. Faino, Stanley Sciortino, Yiting Wang, Melis A. Aksit, Hua Ling, Derek L. Osorio, Frankline M. Onchiri, Shivani U. Patel, Christian A. Merlo, Kristina Montemayor, Ronald L. Gibson, Natalie E. West, Amita Thakerar, Robert J. Bridges, David N. Sheppard, Neeraj Sharma, Garry R. Cutting
Publikováno v:
JCI Insight, Vol 7, Iss 6 (2022)
The chloride channel dysfunction caused by deleterious cystic fibrosis transmembrane conductance regulator (CFTR) variants generally correlates with severity of cystic fibrosis (CF). However, 3 adults bearing the common severe variant p.Phe508del (le
Externí odkaz:
https://doaj.org/article/78b4738b6909425d927439919d715df3
Autor:
Kirsten A. Cottrill, Vincent D. Giacalone, Camilla Margaroli, Robert J. Bridges, Michael Koval, Rabindra Tirouvanziam, Nael A. McCarty
Publikováno v:
Physiological Reports, Vol 9, Iss 17, Pp n/a-n/a (2021)
Abstract Loss of function of the cystic fibrosis transmembrane conductance regulator (CFTR) causes cystic fibrosis (CF). In the lungs, this manifests as immune cell infiltration and bacterial infections, leading to tissue destruction. Previous work h
Externí odkaz:
https://doaj.org/article/643f626715024b628d46003c13d0b820
Autor:
Kirsten A. Cottrill, Raven J. Peterson, Colby F. Lewallen, Michael Koval, Robert J. Bridges, Nael A. McCarty
Publikováno v:
Physiological Reports, Vol 9, Iss 15, Pp n/a-n/a (2021)
Abstract The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel whose dysfunction causes cystic fibrosis (CF). The loss of CFTR function in pulmonary epithelial cells causes surface dehydration, mucus build‐up, inflammat
Externí odkaz:
https://doaj.org/article/ab84396bd5ba466c8fa59996606ebd95
Publikováno v:
American Journal of Physiology-Cell Physiology. 323:C1215-C1230
We previously identified potentiators of KCa3.1 (5,6-dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one; DCEBIO) that stimulate Cl− secretion across human bronchial epithelial cells (HBEs) expressing wild-type (WT) cystic fibrosis transmembrane con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f4e0b3b7d0f9ffc789862480b39ab07
https://doi.org/10.1152/ajpcell.00319.2022
https://doi.org/10.1152/ajpcell.00319.2022
Autor:
Robert A. Bridges, Sean Oesch, Michael D. Iannacone, Kelly M. T. Huffer, Brian Jewell, Jeff A. Nichols, Brian Weber, Miki E. Verma, Daniel Scofield, Craig Miles, Thomas Plummer, Mark Daniell, Anne M. Tall, Justin M. Beaver, Jared M. Smith
Publikováno v:
Digital Threats: Research and Practice.
There is a lack of scientific testing of commercially available malware detectors, especially those that boast accurate classification of never-before-seen (i.e., zero-day) files using machine learning (ML). Consequently, efficacy of malware detector
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33d9a0ff72badc9c93947a07e7cb236e
https://doi.org/10.1145/3567432
https://doi.org/10.1145/3567432
Autor:
Matthew D. Strub, Shyam Ramachandran, Dmitri Y. Boudko, Ella A. Meleshkevitch, Alejandro A. Pezzulo, Aravind Subramanian, Arthur Liberzon, Robert J. Bridges, Paul B. McCray
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 2, Pp 240-251 (2022)
Cystic fibrosis (CF) is a lethal autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The common ΔF508‐CFTR mutation results in protein misfolding and proteasomal degradation. If
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69927bce9f5a70344d83ee3912fc5e1
https://doi.org/10.1002/psp4.12751
https://doi.org/10.1002/psp4.12751
Autor:
Jordan J. Sosnowski, Samuel C. Hollifield, Michael D. Iannacone, Miki E. Verma, Robert A. Bridges
Publikováno v:
IEEE Transactions on Vehicular Technology. 70:9685-9700
Controller area networks (CANs) are a broadcast protocol for real-time communication of critical vehicle subsystems. Original equipment manufacturers of passenger vehicles hold secret their mappings of CAN data to vehicle signals, and these definitio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae50387025f6e1bf7287de2436b39c7c
https://doi.org/10.1109/tvt.2021.3092354
https://doi.org/10.1109/tvt.2021.3092354