Zobrazeno 1 - 10
of 1 120
pro vyhledávání: '"Robert A. Bradley"'
An autoregulatory poison exon in Smndc1 is conserved across kingdoms and influences organism growth.
Autor:
Andrea E Belleville, James D Thomas, Jackson Tonnies, Austin M Gabel, Andrea Borrero Rossi, Priti Singh, Christine Queitsch, Robert K Bradley
Publikováno v:
PLoS Genetics, Vol 20, Iss 8, p e1011363 (2024)
Many of the most highly conserved elements in the human genome are "poison exons," alternatively spliced exons that contain premature termination codons and permit post-transcriptional regulation of mRNA abundance through induction of nonsense-mediat
Externí odkaz:
https://doaj.org/article/2702abd2857a40798e0927e14c8e9f70
Autor:
Austin M. Gabel, Andrea E. Belleville, James D. Thomas, Siegen A. McKellar, Taylor R. Nicholas, Toshihiro Banjo, Edie I. Crosse, Robert K. Bradley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Alternative polyadenylation (APA) is strikingly dysregulated in many cancers. Although global APA dysregulation is frequently associated with poor prognosis, the importance of most individual APA events is controversial simply because few ha
Externí odkaz:
https://doaj.org/article/38f1b82c8b184f27a198e5de36ed4995
Autor:
Emily A. Wright, Madison B. Reddock, Emma K. Roberts, Yoseph W. Legesse, Gad Perry, Robert D. Bradley
Publikováno v:
PeerJ, Vol 12, p e17552 (2024)
Transmissible spongiform encephalopathies (TSEs) are a fatal neurogenerative disease that include Creutzfeldt–Jakob disease in humans, scrapie in sheep and goats, bovine spongiform encephalopathy (BSE), and several others as well as the recently de
Externí odkaz:
https://doaj.org/article/9bf4ad34456a43a99b98f40155a74a4b
Publikováno v:
eLife, Vol 12 (2024)
Cancer immune evasion contributes to checkpoint immunotherapy failure in many patients with metastatic cancers. The embryonic transcription factor DUX4 was recently characterized as a suppressor of interferon-γ signaling and antigen presentation tha
Externí odkaz:
https://doaj.org/article/fd7d1d0ccf2346e9aa165a47751997e3
Autor:
Egie E. Enabulele, Winka Le Clec’h, Emma K. Roberts, Cody W. Thompson, Molly M. McDonough, Adam W. Ferguson, Robert D. Bradley, Timothy J. C. Anderson, Roy N. Platt
Publikováno v:
Emerging Infectious Diseases, Vol 29, Iss 8, Pp 1566-1579 (2023)
More than 60 zoonoses are linked to small mammals, including some of the most devastating pathogens in human history. Millions of museum-archived tissues are available to understand natural history of those pathogens. Our goal was to maximize the val
Externí odkaz:
https://doaj.org/article/acd864c5ed8946bcabd159d8b11caa46
Autor:
Emma K. Roberts, Steve Tardif, Emily A. Wright, Roy N. Platt, Robert D. Bradley, Daniel M. Hardy
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-35 (2022)
Abstract Background Speciation genes contribute disproportionately to species divergence, but few examples exist, especially in vertebrates. Here we test whether Zan, which encodes the sperm acrosomal protein zonadhesin that mediates species-specific
Externí odkaz:
https://doaj.org/article/b94e0ebaecb7453c93eb078fb6a92c57
Autor:
William Dunker, Shivam A. Zaver, Jose Mario Bello Pineda, Cameron J. Howard, Robert K. Bradley, Joshua J. Woodward
Publikováno v:
JCI Insight, Vol 8, Iss 12 (2023)
Cyclic GMP-AMP synthase (cGAS) is a DNA sensor and responsible for inducing an antitumor immune response. Recent studies reveal that cGAS is frequently inhibited in cancer, and therapeutic targets to promote antitumor cGAS function remain elusive. SR
Externí odkaz:
https://doaj.org/article/7052b61a50574159ad243b8dd55f38e5
Publikováno v:
Diversity, Vol 15, Iss 11, p 1145 (2023)
The extraordinary morphological diversity among extant mammals poses a challenge for studies of speciation, adaptation, molecular evolution, and reproductive isolation. Despite the recent wealth of molecular studies on mammalian phylogenetics, uncert
Externí odkaz:
https://doaj.org/article/baea1ed2b7924d9292fee33ed89590fe
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Autor:
Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
RIT1 mutations are mutually exclusive with other lung cancer drivers and lack targeted therapies. Here the authors examine genetic dependencies of mutant RIT1 with genome-wide CRISPR screens, revealing synergy between RIT1 and YAP1, and increased sen
Externí odkaz:
https://doaj.org/article/06e749d7f425413a87006cc1366f2c04
Autor:
Gaurav S Choudhary, Andrea Pellagatti, Bogos Agianian, Molly A Smith, Tushar D Bhagat, Shanisha Gordon-Mitchell, Srabani Sahu, Sanjay Pandey, Nishi Shah, Srinivas Aluri, Ritesh Aggarwal, Sarah Aminov, Leya Schwartz, Violetta Steeples, Robert N Booher, Murali Ramachandra, Maria Samson, Milagros Carbajal, Kith Pradhan, Teresa V Bowman, Manoj M Pillai, Britta Will, Amittha Wickrema, Aditi Shastri, Robert K Bradley, Robert E Martell, Ulrich G Steidl, Evripidis Gavathiotis, Jacqueline Boultwood, Daniel T Starczynowski, Amit Verma
Publikováno v:
eLife, Vol 11 (2022)
Background: Mutations in the SF3B1 splicing factor are commonly seen in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), yet the specific oncogenic pathways activated by mis-splicing have not been fully elucidated. Inflammatory immun
Externí odkaz:
https://doaj.org/article/530c5c84de264ae68b3135c39fce561b