Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Robert A. Bone"'
Autor:
Alexandrina Balanean, Samuel Baird, Brooke Dulka, Luke Jennings‐Zhang, Robert N. Bone, Yolaine Jeune‐Smith, Bruce Feinberg, Muhamed Baljevic
Publikováno v:
eJHaem, Vol 5, Iss 6, Pp 1154-1164 (2024)
Abstract Introduction Initially approved for the fifth‐line or later therapeutic setting, the chimeric antigen receptor (CAR) T‐cell regimen ciltacabtagene autoleucel (cilta‐cel) was recently approved for second‐line (2L) treatment in relapse
Externí odkaz:
https://doaj.org/article/f96f1b2f20a343e0b5ab4238e1bad89f
Autor:
Javier Martin Gonzalez, Sophie M. Morgani, Robert A. Bone, Kasper Bonderup, Sahar Abelchian, Cord Brakebusch, Joshua M. Brickman
Publikováno v:
Stem Cell Reports, Vol 7, Iss 2, Pp 177-191 (2016)
Embryonic stem cells (ESCs) are cell lines derived from the mammalian pre-implantation embryo. Here we assess the impact of derivation and culture conditions on both functional potency and ESC transcriptional identity. Individual ESCs cultured in eit
Externí odkaz:
https://doaj.org/article/ebe5d83f8ce1449da14f67cbdc1edb8f
Autor:
Farooq Syed, Divya Singhal, Koen Raedschelders, Preethi Krishnan, Robert N. Bone, Madeline R. McLaughlin, Jennifer E. Van Eyk, Raghavendra G. Mirmira, Mei-Ling Yang, Mark J. Mamula, Huanmei Wu, Xiaowen Liu, Carmella Evans-Molina
Publikováno v:
EBioMedicine, Vol 87, Iss , Pp 104379- (2023)
Summary: Background: Stress responses within the β cell have been linked with both increased β cell death and accelerated immune activation in type 1 diabetes (T1D). At present, information on the timing and scope of these responses as well as dise
Externí odkaz:
https://doaj.org/article/e4d20da624eb40df994a03c5fc5bd7ca
Autor:
Jose Casasnovas, Christopher Luke Damron, James Jarrell, Kara S. Orr, Robert N. Bone, Stephanie Archer-Hartmann, Parastoo Azadi, Kok Lim Kua
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Offspring of obese mothers suffer higher risks of type 2 diabetes due to increased adiposity and decreased β cell function. To date, the sex-differences in offspring islet insulin secretion during early life has not been evaluated extensively, parti
Externí odkaz:
https://doaj.org/article/39ed121fee024f5aba04980c08119cf1
Autor:
Alexander J. Nelson, Daniel J. Stephenson, Robert N. Bone, Christopher L. Cardona, Margaret A. Park, Ying G. Tusing, Xiaoyong Lei, George Kokotos, Christina L. Graves, Clayton E. Mathews, Joanna Kramer, Martin J. Hessner, Charles E. Chalfant, Sasanka Ramanadham
Publikováno v:
JCI Insight, Vol 5, Iss 16 (2020)
Type 1 diabetes (T1D) is a consequence of autoimmune β cell destruction, but the role of lipids in this process is unknown. We previously reported that activation of Ca2+-independent phospholipase A2β (iPLA2β) modulates polarization of macrophages
Externí odkaz:
https://doaj.org/article/acc96d8d77f847bb9d00e773a381249e
Autor:
Rebecca K. Davidson, Sukrati Kanojia, Wenting Wu, Tatsuyoshi Kono, Jerry Xu, Meredith Osmulski, Robert N. Bone, Nolan Casey, Carmella Evans-Molina, Emily K. Sims, Jason M. Spaeth
The transcriptional activity of Pdx1 is modulated by a diverse array of coregulatory factors that govern chromatin accessibility, histone modifications, and nucleosome distribution. We previously identified the Chd4 subunit of the nucleosome remodeli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a03ae668fe75f1bb64d63f350f20ed1
https://doi.org/10.2337/figshare.22236679
https://doi.org/10.2337/figshare.22236679
Autor:
Sasanka Ramanadham, Tomader Ali, Jason W. Ashley, Robert N. Bone, William D. Hancock, Xiaoyong Lei
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 9, Pp 1643-1668 (2015)
Among the family of phospholipases A2 (PLA2s) are the Ca2+-independent PLA2s (iPLA2s) and they are designated group VI iPLA2s. In relation to secretory and cytosolic PLA2s, the iPLA2s are more recently described and details of their expression and ro
Externí odkaz:
https://doaj.org/article/21e6391acba34f2581abdc148f3fed1f
Publikováno v:
Blood. 140:10958-10959
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d17d08ffe842ba4ca664f57298609fdc
https://doi.org/10.1182/blood-2022-166490
https://doi.org/10.1182/blood-2022-166490
Publikováno v:
Blood. 140:13234-13235
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ea2c87b87e8aa73e174c76a2cd44524
https://doi.org/10.1182/blood-2022-166976
https://doi.org/10.1182/blood-2022-166976
Autor:
Hitoshi Iida, Tatsuyoshi Kono, Chih-Chun Lee, Preethi Krishnan, Matthew C. Arvin, Staci A. Weaver, Timothy S. Jarvela, Robert N. Bone, Xin Tong, Peter Arvan, Iris Lindberg, Carmella Evans-Molina
Increased circulating levels of incompletely processed insulin (i.e. proinsulin) are observed clinically in both type 1 and type 2 diabetes; however, the mechanisms underlying impaired proinsulin processing remain incompletely understood. Here, we id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4650c5d2e43900ce537422c5527ef5b1
https://doi.org/10.1101/2022.06.13.495980
https://doi.org/10.1101/2022.06.13.495980