Zobrazeno 1 - 10
of 483
pro vyhledávání: '"Robert A. Austin"'
Autor:
Shengkai Li, Trung V. Phan, Gao Wang, Ramzi Khuri, Jared W. Wilson, Robert H. Austin, Liyu Liu
Publikováno v:
Communications Physics, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract Inertial underdamped collisions preserve the memory of physical parameters that existed before the collision, leading to phenomena usually unseen in overdamped systems. Here we probe the less studied inertial chiral matter with spinners on a
Externí odkaz:
https://doaj.org/article/d7333d33c28f4018bc992058d6024929
Publikováno v:
Frontiers in Sociology, Vol 9 (2024)
Externí odkaz:
https://doaj.org/article/9b6f6a1c9b594764b9b11cefaa607a28
Autor:
Wanyoung Lim, Inwoo Hwang, Jiande Zhang, Zhenzhong Chen, Jeonghun Han, Jaehyung Jeon, Bon-Kyoung Koo, Sangmin Kim, Jeong Eon Lee, Youngkwan Kim, Kenneth J Pienta, Sarah R Amend, Robert H Austin, Jee-Yin Ahn, Sungsu Park
Publikováno v:
eLife, Vol 12 (2024)
Chemoresistance is a major cause of treatment failure in many cancers. However, the life cycle of cancer cells as they respond to and survive environmental and therapeutic stress is understudied. In this study, we utilized a microfluidic device to in
Externí odkaz:
https://doaj.org/article/938e5cfba98a4d9f955a45c8b7d44e66
Autor:
Anuraag Bukkuri, Kenneth J. Pienta, Robert H. Austin, Emma U. Hammarlund, Sarah R. Amend, Joel S. Brown
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The polyaneuploid cancer cell (PACC) state promotes cancer lethality by contributing to survival in extreme conditions and metastasis. Recent experimental evidence suggests that post-therapy PACC-derived recurrent populations display cross-r
Externí odkaz:
https://doaj.org/article/bcbd6c09da064051a756848a4f23f88c
Autor:
Anuraag Bukkuri, Kenneth J. Pienta, Sarah R. Amend, Robert H. Austin, Emma U. Hammarlund, Joel S. Brown
Publikováno v:
Ecology and Evolution, Vol 13, Iss 10, Pp n/a-n/a (2023)
Abstract Evolvability is the capacity of a population to generate heritable variation that can be acted upon by natural selection. This ability influences the adaptations and fitness of individual organisms. By viewing this capacity as a trait, evolv
Externí odkaz:
https://doaj.org/article/7e4d9299408e4b9199e84cb6dae86b05
Publikováno v:
Royal Society Open Science, Vol 10, Iss 8 (2023)
The evolution of antibiotic resistance is a fundamental problem in disease management but is rarely quantified on a single-cell level owing to challenges associated with capturing the spatial and temporal variation across a population. To evaluate ce
Externí odkaz:
https://doaj.org/article/911f187d3923462ea7670716e393fb3c
Autor:
Chi-Ju Kim, Anna LK Gonye, Kevin Truskowski, Cheng-Fan Lee, Yoon-Kyoung Cho, Robert H. Austin, Kenneth J. Pienta, Sarah R. Amend
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 42, Iss , Pp 100906- (2023)
The emergence of chemotherapy resistance drives cancer lethality in cancer patients, with treatment initially reducing overall tumor burden followed by resistant recurrent disease. While molecular mechanisms underlying resistance phenotypes have been
Externí odkaz:
https://doaj.org/article/8af064d351f84e628dd1296774c570ee
Autor:
Anuraag Bukkuri, Kenneth J. Pienta, Robert H. Austin, Emma U. Hammarlund, Sarah R. Amend, Joel S. Brown
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Therapeutic resistance is one of the main reasons for treatment failure in cancer patients. The polyaneuploid cancer cell (PACC) state has been shown to promote resistance by providing a refuge for cancer cells from the effects of therapy an
Externí odkaz:
https://doaj.org/article/5e255d74321e44159eab4104663af1f8
Autor:
Anuraag Bukkuri, Kenneth J. Pienta, Robert H. Austin, Emma U. Hammarlund, Sarah R. Amend, Joel S. Brown
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Recent evidence suggests that a polyaneuploid cancer cell (PACC) state may play a key role in the adaptation of cancer cells to stressful environments and in promoting therapeutic resistance. The PACC state allows cancer cells to pause cell
Externí odkaz:
https://doaj.org/article/f9e258e630024871bac773c4cd734baa
Autor:
Sarah R. Amend, Emma U. Hammarlund, Robert Axelrod, Kenneth J. Pienta, Joel S. Brown, Robert H. Austin
Publikováno v:
Pienta, K J, Hammarlund, E U, Austin, R H, Axelrod, R, Brown, J S & Amend, S R 2022, ' Cancer cells employ an evolutionarily conserved polyploidization program to resist therapy ', Seminars in Cancer Biology, vol. 81, pp. 145-159 . https://doi.org/10.1016/j.semcancer.2020.11.016
Unusually large cancer cells with abnormal nuclei have been documented in the cancer literature since 1858. For more than 100 years, they have been generally disregarded as irreversibly senescent or dying cells, too morphologically misshapen and chro