Zobrazeno 1 - 10
of 522
pro vyhledávání: '"Robert A. Anders"'
Autor:
Shuming Chen, Tracee L. McMiller, Abha Soni, Farah Succaria, John-William Sidhom, Laura C. Cappelli, Livia A. Casciola-Rosen, Isaac R. Morales, Preethi Sankaran, Alan E. Berger, Julie Stein Deutsch, Qingfeng C. Zhu, Robert A. Anders, Jody E. Hooper, Drew M. Pardoll, Evan J. Lipson, Janis M. Taube, Suzanne L. Topalian
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background Tumor regression following immune checkpoint blockade (ICB) is often associated with immune-related adverse events (irAEs), marked by inflammation in non-cancerous tissues. This study was undertaken to investigate the functional r
Externí odkaz:
https://doaj.org/article/44edc95deb6444eabbd3e50a4991237d
Autor:
Shuming Zhang, Long Yuan, Ludmila Danilova, Guanglan Mo, Qingfeng Zhu, Atul Deshpande, Alexander T. F. Bell, Jennifer Elisseeff, Aleksander S. Popel, Robert A. Anders, Elizabeth M. Jaffee, Mark Yarchoan, Elana J. Fertig, Luciane T. Kagohara
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Background Novel immunotherapy combination therapies have improved outcomes for patients with hepatocellular carcinoma (HCC), but responses are limited to a subset of patients. Little is known about the inter- and intra-tumor heterogeneity i
Externí odkaz:
https://doaj.org/article/098a7d924d184c9b829632f226e3bd36
Autor:
Joseph Willis, Robert A. Anders, Toshihiko Torigoe, Yoshihiko Hirohashi, Carlo Bifulco, Inti Zlobec, Bernhard Mlecnik, Sandra Demaria, Won-Tak Choi, Pavel Dundr, Fabiana Tatangelo, Annabella Di Mauro, Pamela Baldin, Gabriela Bindea, Florence Marliot, Nacilla Haicheur, Tessa Fredriksen, Amos Kirilovsky, Bénédicte Buttard, Angela Vasaturo, Lucie Lafontaine, Pauline Maby, Carine El Sissy, Assia Hijazi, Amine Majdi, Christine Lagorce, Anne Berger, Marc Van den Eynde, Franck Pagès, Alessandro Lugli, Jérôme Galon
Publikováno v:
Cancers, Vol 15, Iss 16, p 4045 (2023)
Background: The Immunoscore (IS) is a quantitative digital pathology assay that evaluates the immune response in cancer patients. This study reports on the reproducibility of pathologists’ visual assessment of CD3+- and CD8+-stained colon tumors, c
Externí odkaz:
https://doaj.org/article/7426d03a66c4425eabc9e6f970f30903
Autor:
Tao Xia, Keyu Li, Nan Niu, Yingkuan Shao, Ding Ding, Dwayne L. Thomas, Hao Jing, Kenji Fujiwara, Haijie Hu, Arsen Osipov, Chunhui Yuan, Christopher L. Wolfgang, Elizabeth D. Thompson, Robert A. Anders, Jin He, Yiping Mou, Adrian G. Murphy, Lei Zheng
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-20 (2022)
Abstract Background Immunotherapy has demonstrated a limited clinical efficacy in approximately 5% of cholangiocarcinoma. The main challenges for an effective immunotherapy response in cholangiocarcinoma arise from the tumor microenvironment, which i
Externí odkaz:
https://doaj.org/article/0811bea100fd47df96bb43572ac97480
Autor:
Daniel Li, MD, MA, Angela Y. Jia, MD, PhD, Jane Zorzi, BS, Paige Griffith, MSN, AG-ACNP, BSN, Amy K. Kim, MD, Doan Dao, MD, Robert A. Anders, MD, PhD, Christos Georgiades, MD, PhD, Robert P. Liddell, MD, Kelvin Hong, MD, Nilofer S. Azad, MD, Won Jin Ho, MD, Marina Baretti, MD, Eric Christenson, MD, Azarakhsh Baghdadi, MD, MAS, Ihab R. Kamel, MD, PhD, Jeffrey Meyer, MD, Elie Ghabi, MD, Richard A. Burkhart, MD, Kelly Lafaro, MD, MPH, Jin He, MD, Chris Shubert, MD, Mark Yarchoan, MD
Publikováno v:
Annals of Surgery Open, Vol 3, Iss 4, p e207 (2022)
Objectives:. To compare liver cancer resectability rates before and during the COVID-19 pandemic. Background:. Liver cancers usually present with nonspecific symptoms or are diagnosed through screening programs for at-risk patients, and early detecti
Externí odkaz:
https://doaj.org/article/7e5acd49afd340669a8e3f54361f1158
Autor:
Annemarie Boleij, Payam Fathi, William Dalton, Ben Park, Xinqun Wu, David Huso, Jawara Allen, Sepideh Besharati, Robert A. Anders, Franck Housseau, Amanda E. Mackenzie, Laura Jenkins, Graeme. Milligan, Shaoguang Wu, Cynthia L. Sears
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Boleij et al. show that G protein-coupled receptor 35 (GPR35) regulates the responses to enterotoxigenic Bacteroides fragilis (ETBF) in colonic epithelial cells. They find that GPR35-deficiency nearly protected mice from ETBF-induced death, suggestin
Externí odkaz:
https://doaj.org/article/2986eba9551643dc8608d3a4c5b5b496
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers due to low therapeutic response rates and poor prognoses. Majority of patients present with symptoms post metastatic spread, which contributes to its overall lethality as th
Externí odkaz:
https://doaj.org/article/8fbdea4367b240f496e4f6ddb4f33b2a
Autor:
Mark Yarchoan, Chiung‐Yu Huang, Qingfeng Zhu, Anna K. Ferguson, Jennifer N. Durham, Robert A. Anders, Elizabeth D. Thompson, Noah S. Rozich, Dwayne L. Thomas II, Julie M. Nauroth, Christina Rodriguez, Arsen Osipov, Ana De Jesus‐Acosta, Dung T. Le, Adrian G. Murphy, Daniel Laheru, Ross C. Donehower, Elizabeth M. Jaffee, Lei Zheng, Nilofer S. Azad
Publikováno v:
Cancer Medicine, Vol 9, Iss 4, Pp 1485-1494 (2020)
Abstract Background Mismatch repair proficient (MMRp) colorectal cancer (CRC) has been refractory to single‐agent programmed cell death protein 1 (PD1) inhibitor therapy. Colon GVAX is an allogeneic, whole‐cell, granulocyte‐macrophage colony‐
Externí odkaz:
https://doaj.org/article/d4ba8200190f4f8999ae7ef37f32141a
Autor:
Angela Y. Jia MD, PhD, Aleksandra Popovic BS, Aditya A. Mohan BS, Jane Zorzi BS, Paige Griffith MSN, AG-ACNP, BSN, Amy K. Kim MD, Robert A. Anders MD, PhD, Richard A. Burkhart MD, Kelly Lafaro MD, MPH, Christos Georgiades MD, PhD, Nilofer S. Azad MD, Robert P. Liddell MD, Marina Baretti MD, Ihab R. Kamel MD, PhD, Amol Narang MD, Mark Yarchoan MD, Jeffrey Meyer MD
Publikováno v:
Cancer Control, Vol 28 (2021)
Multidisciplinary care has been associated with improved survival in patients with primary liver cancers. We report the practice patterns and real world clinical outcomes for patients presenting to the Johns Hopkins Hospital (JHH) multidisciplinary l
Externí odkaz:
https://doaj.org/article/034223e2cef847608ca5c19b928d6819
Autor:
Kellie N. Smith, Nicolas J. Llosa, Tricia R. Cottrell, Nicholas Siegel, Hongni Fan, Prerna Suri, Hok Yee Chan, Haidan Guo, Teniola Oke, Anas H. Awan, Franco Verde, Ludmila Danilova, Valsamo Anagnostou, Ada J. Tam, Brandon S. Luber, Bjarne R. Bartlett, Laveet K. Aulakh, John-William Sidhom, Qingfeng Zhu, Cynthia L. Sears, Leslie Cope, William H. Sharfman, Elizabeth D. Thompson, Joanne Riemer, Kristen A. Marrone, Jarushka Naidoo, Victor E. Velculescu, Patrick M. Forde, Bert Vogelstein, Kenneth W. Kinzler, Nickolas Papadopoulos, Jennifer N. Durham, Hao Wang, Dung T. Le, Sune Justesen, Janis M. Taube, Luis A. Diaz, Julie R. Brahmer, Drew M. Pardoll, Robert A. Anders, Franck Housseau
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-8 (2019)
Abstract Background Several predictive biomarkers are currently approved or are under investigation for the selection of patients for checkpoint blockade. Tumor PD-L1 expression is used for stratification of non-small cell lung (NSCLC) patients, with
Externí odkaz:
https://doaj.org/article/1bbf8602f6f8428183fdc7d49f984cca