Výsledky vyhledávání - "Robert A. Ach"

The repressive genome compartment is established early in the cell cycle before forming the lamina associated domains

Autor: Michael E.G. Sauria, M. C. Gaillard, Katja Pekrun, Xianrong Wong, Robert A. Ach, E. DeBoy, James Taylor, N. A. Yamada, Peter Tsang, Victoria E. Hoskins, Karen L. Reddy, Teresa Romeo Luperchio

Three-dimensional (3D) genome organization is thought to be important for regulation of gene expression. Chromosome conformation capture-based studies have uncovered ensemble organizational principles such as active (A) and inactive (B) compartmental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2afe9df4e076c73243b4b26d906e0c

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Chromosome Conformation Paints Reveal the Role of Lamina Association in Genome Organization and Regulation

Autor: Marie Cécile Gaillard, Peter Tsang, Teresa Romeo Luperchio, Katja Pekrun, Robert A. Ach, James Taylor, Xianrong Wong, N. Alice Yamada, Michael E.G. Sauria, Karen L. Reddy

SummaryNon-random, dynamic three-dimensional organization of the nucleus is important for regulation of gene expression. Numerous studies using chromosome conformation capture strategies have uncovered ensemble organizational principles of individual

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd160c5d0330ae30ce11e9685dd4a50a

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Abstract 1403: Combining oligonucleotide library-based RNA fluorescence in situ hybridization and fluorescent immunohistochemistry on the same tissue section

Autor: Robert A. Ach, May Tom-Moy, Peter Tsang, Kelly Kroeger

Publikováno v: Cancer Research. 79:1403-1403

The ability to visualize both RNA and protein expression in a single formalin-fixed paraffin-embedded (FFPE) tissue section is a powerful technique for studying biological problems such as the regulation of protein expression and RNA/protein interact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::230368414fdda7ff9f400bbf903e80fa
https://doi.org/10.1158/1538-7445.am2019-1403

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Direct and sensitive miRNA profiling from low-input total RNA

Autor: Robert A. Ach, Bo Curry, Hui Wang

Publikováno v: RNA. 13:151-159

We have developed a sensitive, accurate, and multiplexed microRNA (miRNA) profiling assay that is based on a highly efficient labeling method and novel microarray probe design. The probes provide both sequence and size discrimination, yielding in mos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c49d08a77815e72d7e6e3f1d6e88821e
https://doi.org/10.1261/rna.234507

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RRB1 and RRB2 Encode Maize Retinoblastoma-Related Proteins That Interact with a Plant D-Type Cyclin and Geminivirus Replication Protein

Autor: Linda Hanley-Bowdoin, Patti Taranto, Wilhelm Gruissem, Patricia Zambryski, Ann B. Miller, Tim Durfee, Robert A. Ach

Publikováno v: Molecular and Cellular Biology. 17:5077-5086

Unlike mammalian and yeast cells, little is known about how plants regulate G1 progression and entry into the S phase of the cell cycle. In mammalian cells, a key regulator of this process is the retinoblastoma tumor suppressor protein (RB). In contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5428567469cbc93aadeb5b62474c1f9b
https://doi.org/10.1128/mcb.17.9.5077

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A Prader-Willi locus lncRNA cloud modulates diurnal genes and energy expenditure

Autor: Florence K. Crary, Rochelle L. Coulson, Dag H. Yasui, N. Alice Yamada, Robert A. Ach, Peter Tsang, Weston T. Powell, Janine M. LaSalle, Spencer S. Wong

Publikováno v: Human Molecular Genetics

Prader-Willi syndrome (PWS), a genetic disorder of obesity, intellectual disability and sleep abnormalities, is caused by loss of non-coding RNAs on paternal chromosome 15q11-q13. The imprinted minimal PWS locus encompasses a long non-coding RNA (lnc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9208a2d69a60b414f5b920b4afcb2d6a
https://pubmed.ncbi.nlm.nih.gov/23771028

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lincRNAs act in the circuitry controlling pluripotency and differentiation

Autor: Xiaoping Yang, Robert A. Ach, Manuel Garber, Aviv Regev, Eric S. Lander, Julie Donaghey, Jennifer K. Grenier, Mitchell Guttman, Alexander Meissner, John L. Rinn, Laurakay Bruhn, Geneva Young, Anne Bergstrom Lucas, Ido Amit, Bryce W. Carey, Glen Munson, David E. Root

Publikováno v: Nature
PMC

Although thousands of large intergenic non-coding RNAs (lincRNAs) have been identified in mammals, few have been functionally characterized, leading to debate about their biological role. To address this, we performed loss-of-function studies on most

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553421fc778f4cf221a4bd9d5391c423
https://pubmed.ncbi.nlm.nih.gov/22539754

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Cooperation between CCAAT and octamer motifs in the distal sequence element of the rat U3 small nucleolar RNA promoter

Autor: Robert A. Ach, Alan M. Weiner

Publikováno v: Nucleic Acids Research. 19:4209-4218

Mammalian U3 small nucleolar RNA promoters possess a highly conserved distal sequence element (DSE) consisting of CCAAT and octamer motifs separated by 11-12 base pairs. We show here that both motifs are required for transcription of a rat U3D gene i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cdd76d9e94f911708afbeb86f3ae874
https://doi.org/10.1093/nar/19.15.4209

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