Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Robert A McCutcheon"'
Autor:
Fran Hancock, Fernando E Rosas, Robert A McCutcheon, Joana Cabral, Ottavia Dipasquale, Federico E Turkheimer
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0282707 (2023)
The disconnection hypothesis of schizophrenia proposes that symptoms of the disorder arise as a result of aberrant functional integration between segregated areas of the brain. The concept of metastability characterizes the coexistence of competing t
Externí odkaz:
https://doaj.org/article/3da3dc0adf7940bda5f88172c423483e
Publikováno v:
eLife, Vol 8 (2019)
Chronic psychosocial adversity induces vulnerability to mental illnesses. Animal studies demonstrate that this may be mediated by dopaminergic dysfunction. We therefore investigated whether long-term exposure to psychosocial adversity was associated
Externí odkaz:
https://doaj.org/article/86cda3e2c7054ac5af40c132653d7d38
Autor:
Matthew M Nour, Tarik Dahoun, Robert A McCutcheon, Rick A Adams, Matthew B Wall, Oliver D Howes
Publikováno v:
eLife, Vol 8 (2019)
Working memory performance is thought to depend on both striatal dopamine 2/3 receptors (D2/3Rs) and task-induced functional organisation in key cortical brain networks. Here, we combine functional magnetic resonance imaging and D2/3R positron emissi
Externí odkaz:
https://doaj.org/article/6ecafc1c17564f29a1db983d8845f764
Autor:
Katherine Beck, Atheeshaan Arumuham, Mattia Veronese, Barbara Santangelo, Colm J. McGinnity, Joel Dunn, Robert A. McCutcheon, Stephen J. Kaar, Nisha Singh, Toby Pillinger, Faith Borgan, James Stone, Sameer Jauhar, Teresa Sementa, Federico Turkheimer, Alexander Hammers, Oliver D. Howes
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract N-methyl-D-aspartate receptor (NMDAR) hypofunction is hypothesised to underlie psychosis but this has not been tested early in illness. To address this, we studied 40 volunteers (21 patients with first-episode psychosis and 19 matched health
Externí odkaz:
https://doaj.org/article/01e5daca97374a1c9b30a252f899148c
Autor:
Uzma Zahid, Robert A. McCutcheon, Faith Borgan, Sameer Jauhar, Fiona Pepper, Matthew M. Nour, Maria Rogdaki, Martin Osugo, Graham K. Murray, Pamela Hathway, Robin M. Murray, Alice Egerton, Oliver D. Howes
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
IntroductionGlutamatergic dysfunction is implicated in the pathophysiology of schizophrenia. It is unclear whether glutamatergic dysfunction predicts response to treatment or if antipsychotic treatment influences glutamate levels. We investigated the
Externí odkaz:
https://doaj.org/article/ef7fcfab14ee4946aed61942d82d31bb
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Alterations in cortical inter-areal functional connectivity, and aberrant glutamatergic signalling are implicated in the pathophysiology of schizophrenia but the relationship between the two is unclear. We used multimodal imaging to identify
Externí odkaz:
https://doaj.org/article/aacd9938169b4bf1a550435ce7eab52f
Autor:
John Tully, Ben Cross, Brooke Gerrie, Julia Griem, Nigel Blackwood, Robert James Blair, Robert A. McCutcheon
Publikováno v:
Nature Mental Health. 1:163-173
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c6de1b99dba25c3d2e0d58c6b62ea25
https://doi.org/10.1038/s44220-023-00032-0
https://doi.org/10.1038/s44220-023-00032-0
Autor:
Toby Pillinger, Emanuele F Osimo, Antonio de Marvao, Mit Shah, Catherine Francis, Jian Huang, Enrico D'Ambrosio, Joseph Firth, Matthew M Nour, Robert A McCutcheon, Antonio F Pardiñas, Paul M Matthews, Declan P O'Regan, Oliver D Howes
Publikováno v:
Pillinger, T, Osimo, EF, de, M A, D'Ambrosio, E, Firth, J, Nour, MM, McCutcheon, RA, Pardiñas, AF, O'Regan, DP & Howes, OD 2023, ' Effect of polygenic risk for schizophrenia on cardiac structure and function: a UK Biobank observational study. ', The lancet. Psychiatry, vol. 10, no. 2, pp. 98-107 . https://doi.org/10.1016/s2215-0366(22)00403-5
Background:Cardiovascular disease is a major cause of excess mortality in people with schizophrenia. Several factors are responsible, including lifestyle and metabolic effects of antipsychotics. However, variations in cardiac structure and function a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51852b042e7ae462e5c0e585e8d07bbc
https://doi.org/10.1016/s2215-0366(22)00403-5
https://doi.org/10.1016/s2215-0366(22)00403-5
Autor:
Sameer Jauhar, Robert A. McCutcheon, Mattia Veronese, Faith Borgan, Matthew Nour, Maria Rogdaki, Fiona Pepper, James M. Stone, Alice Egerton, George Vamvakas, Federico Turkheimer, Philip K. McGuire, Oliver D. Howes
Publikováno v:
Translational Psychiatry
The neuromodulator dopamine and excitatory neurotransmitter glutamate have both been implicated in the pathogenesis of psychosis, and dopamine antagonists remain the predominant treatment for psychotic disorders. To date no study has measured the eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2244aebc266132f8bfd4e4f4b5201ef0
https://hdl.handle.net/21.11116/0000-000D-3DA9-1
https://hdl.handle.net/21.11116/0000-000D-3DA9-1
Autor:
Borja Pedruzo, Claudia Aymerich, Malein Pacho, Jon Herrero, María Laborda, Marta Bordenave, Anthony J. Giuliano, Robert A. McCutcheon, Luis Gutiérrez-Rojas, Philip McGuire, William S. Stone, Paolo Fusar-Poli, Miguel Ángel González-Torres, Ana Catalan
Publikováno v:
European Child & Adolescent Psychiatry.
Clinical high risk of psychosis (CHR-P) population has become an attractive area of interest in preventing transitions to psychosis. The consequences of developing a psychotic disorder may be worse in cases of early onset. Thus, childhood and adolesc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d72efe76bbe984720dc6bd3e8199cc2
https://doi.org/10.1007/s00787-023-02221-9
https://doi.org/10.1007/s00787-023-02221-9