Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Robert A Kirken"'
Autor:
Armando Estrada, Alejandro C. Rodriguez, Georgialina Rodriguez, Alice H. Grant, Yoshira M. Ayala-Marin, Amy J. Arrieta, Robert A. Kirken
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract T-cell activation and cellular expansion by common gamma chain cytokines such as Interleukin-2 is necessary for adaptive immunity. However, when unregulated these same pathways promote pathologies ranging from autoimmune disorders to cancer.
Externí odkaz:
https://doaj.org/article/9512cc6ef415433aa641845f6ef594ca
Autor:
Shengjie Sun, Georgialina Rodriguez, Yixin Xie, Wenhan Guo, Alan E. Lopez Hernandez, Jason E. Sanchez, Robert Arthur Kirken, Lin Li
Publikováno v:
Life, Vol 13, Iss 4, p 981 (2023)
Janus Kinase 3 (JAK3) plays a key role in the development, proliferation, and differentiation of various immune cells. It regulates gene expression by phosphorylation of Signal Transducers and Activators of Transcriptions (STATs) via the JAK/STAT pat
Externí odkaz:
https://doaj.org/article/2fbecfce9ae2446681b571d497480034
Autor:
Elisa Robles-Escajeda, Jonathon E. Mohl, Lisett Contreras, Ana P. Betancourt, Bibiana M. Mancera, Robert A. Kirken, Georgialina Rodriguez
Publikováno v:
Viruses, Vol 15, Iss 3, p 658 (2023)
COVID-19, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), remains an ongoing global health challenge. This study analyzed 3641 SARS-CoV-2 positive samples from the El Paso, Texas, community and hospitalized patients over 4
Externí odkaz:
https://doaj.org/article/4c5485917aa64341ab8d8ae95655c34a
Autor:
Alice H. Grant, Armando Estrada, Yoshira M. Ayala-Marin, America Y. Alvidrez-Camacho, Georgialina Rodriguez, Elisa Robles-Escajeda, Denisse A. Cadena-Medina, Alejandro C. Rodriguez, Robert A. Kirken
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The positive-sense single stranded RNA virus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), resulted in a global pandemic with horrendous health and economic consequences not seen in a century. At a finer scale, immunologically, many
Externí odkaz:
https://doaj.org/article/fd93700fa4a744979cbff590d5c2c9e5
Autor:
Lisa L.R. Hartman, Derrick M. Oaxaca, Benjamin Carcamo, Harry L. Wilson, Jeremy A. Ross, Elisa Robles-Escajeda, Robert A. Kirken
Publikováno v:
Case Reports in Oncology, Vol 12, Iss 1, Pp 211-217 (2019)
Embryonal tumor with multilayered rosettes (ETMR) are rare pediatric brain tumors with increased malignant potential. Despite the advances in multimodal treatment schemes the overall 5-year event free survival rates for ETMR are not favorable. Furthe
Externí odkaz:
https://doaj.org/article/4e137ce11e7042f88329e4bb967e32ec
Autor:
Jessica D. Hess, Luca H. Macias, Denisse A. Gutierrez, Karla Moran-Santibanez, Lisett Contreras, Stephanie Medina, Paulina J. Villanueva, Robert A. Kirken, Armando Varela-Ramirez, Manuel L. Penichet, Renato J. Aguilera
Publikováno v:
Biology, Vol 11, Iss 6, p 930 (2022)
In recent years, the thienopyrazole moiety has emerged as a pharmacologically active scaffold with antitumoral and kinase inhibitory activity. In this study, high-throughput screening of 2000 small molecules obtained from the ChemBridge DIVERset libr
Externí odkaz:
https://doaj.org/article/ecd0ac3c2f914b6c81921427813e37b2
Autor:
Denisse A. Gutierrez, Lisett Contreras, Paulina J. Villanueva, Edgar A. Borrego, Karla Morán-Santibañez, Jessica D. Hess, Rebecca DeJesus, Manuel Larragoity, Ana P. Betancourt, Jonathon E. Mohl, Elisa Robles-Escajeda, Khodeza Begum, Sourav Roy, Robert A. Kirken, Armando Varela-Ramirez, Renato J. Aguilera
Publikováno v:
Cells, Vol 11, Iss 2, p 254 (2022)
In this study, we identified a novel pyrazole-based derivative (P3C) that displayed potent cytotoxicity against 27 human cancer cell lines derived from different tissue origins with 50% cytotoxic concentrations (CC50) in the low micromolar and nanomo
Externí odkaz:
https://doaj.org/article/5cbd8028ab8145fe8e7fc335095f7d64
Autor:
Alice H. Grant, Alejandro C. Rodriguez, Omar J. Rodriguez Moncivais, Shengjie Sun, Lin Li, Jonathon E. Mohl, Ming-Ying Leung, Robert A. Kirken, Georgialina Rodriguez
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 7; Pages: 6805
Overactive Janus kinases (JAKs) are known to drive leukemia, making them well-suited targets for treatment. We sought to identify new JAK-activating mutations and instead found a JAK1-inactivating pseudokinase mutation, V666G. In contrast to other ps
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::661e57f43da61cfeb98c7744052ce3d2
Autor:
Marja T. Nevalainen, James Karras, Robert A. Kirken, Lukas Bubendorf, Tapio Visakorpi, Zoran Culig, Tobias Zellweger, Edward P. Gelmann, Ying Zhang, Junaid Abdulghani, Zhiyong Liao, Lei Gu, Feng Shen, Ayush Dagvadorj, Shyh-Han Tan
Supplementary Figure 1 from Transcription Factor Stat5 Synergizes with Androgen Receptor in Prostate Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fdfc39b6b17e157690943de317a6cf0
https://doi.org/10.1158/0008-5472.22371183
https://doi.org/10.1158/0008-5472.22371183
Autor:
Marja T. Nevalainen, James Karras, Robert A. Kirken, Lukas Bubendorf, Tapio Visakorpi, Zoran Culig, Tobias Zellweger, Edward P. Gelmann, Ying Zhang, Junaid Abdulghani, Zhiyong Liao, Lei Gu, Feng Shen, Ayush Dagvadorj, Shyh-Han Tan
The molecular mechanisms underlying progression of prostate cancer to the hormone-independent state are poorly understood. Signal transducer and activator of transcription 5a and 5b (Stat5a/b) is critical for the viability of human prostate cancer ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97f27aeff85e16de6e0a5c157da49e3a
https://doi.org/10.1158/0008-5472.c.6496695
https://doi.org/10.1158/0008-5472.c.6496695