Zobrazeno 1 - 10
of 392
pro vyhledávání: '"Robert A Keenan"'
Publikováno v:
eLife, Vol 13 (2024)
The protein translocon at the endoplasmic reticulum comprises the Sec61 translocation channel and numerous accessory factors that collectively facilitate the biogenesis of secretory and membrane proteins. Here, we leveraged recent advances in cryo-el
Externí odkaz:
https://doaj.org/article/4407370f45984775adebe84f06d6491f
Autor:
Dana E. Rollison, Brian D. Gonzalez, Kea Turner, Heather S. L. Jim, Yayi Zhao, Rossybelle P. Amorrortu, Rachel Howard, Kavita M. Ghia, Bryan Ngo, Phillip Reisman, Colin Moore, Randa Perkins, Robert J. Keenan, David A. Sallman, Cristina M. Naso, Edmondo J. Robinson, Susan T. Vadaparampil, Vani N. Simmons, Matthew B. Schabath, Scott M. Gilbert
Publikováno v:
Cancer Medicine, Vol 12, Iss 18, Pp 19033-19046 (2023)
Abstract Background Patient‐reported data can improve quality of healthcare delivery and patient outcomes. Moffitt Cancer Center (“Moffitt”) administers the Electronic Patient Questionnaire (EPQ) to collect data on demographics, including sexua
Externí odkaz:
https://doaj.org/article/f152c0a7fc304aa4ba295dbe3c599625
Autor:
Jon Golenbiewski, Robert T. Keenan
Publikováno v:
Rheumatology and Therapy, Vol 6, Iss 2, Pp 179-193 (2019)
Abstract Gout is a the most common inflammatory arthritis in the United States. It is a significant cause of morbidity, disability, lost work days, and high healthcare utilization due to intermittent attacks, chronic inflammation, and joint damage. D
Externí odkaz:
https://doaj.org/article/e1c26ab6975f4858aa1d92500c94611b
Publikováno v:
Rheumatology and Therapy, Vol 6, Iss 2, Pp 299-304 (2019)
Abstract Introduction The aim of this work is to evaluate the impact of the timing of pre-infusion serum uric acid (sUA) test results for use in applying stopping rules for pegloticase to identify patients at risk for infusion reactions (IRs) while o
Externí odkaz:
https://doaj.org/article/6a0d84f73d374546af18a453067e696f
Autor:
Usman M. Haroon, Paul C. Ryan, Robert A. Keenan, Nicholas Hegarty, David Mulvin, Barry B. McGuire
Publikováno v:
Urology Case Reports, Vol 33, Iss , Pp 101325- (2020)
A 26-year-old male presented with an obstructing calculus in the mid superior-moiety ureter in a duplicated urinary collecting-system. A sequela of the obstruction resulted in a symptomatic stricture in a functional superior-moiety ureter, unresponsi
Externí odkaz:
https://doaj.org/article/7109ddd8a9504cc3aea7ee18c7bc34fa
Autor:
Philip T McGilvray, S Andrei Anghel, Arunkumar Sundaram, Frank Zhong, Michael J Trnka, James R Fuller, Hong Hu, Alma L Burlingame, Robert J Keenan
Publikováno v:
eLife, Vol 9 (2020)
Membrane proteins with multiple transmembrane domains play critical roles in cell physiology, but little is known about the machinery coordinating their biogenesis at the endoplasmic reticulum. Here we describe a ~ 360 kDa ribosome-associated complex
Externí odkaz:
https://doaj.org/article/8812d76dadcd4bab841ae217dfac2ebd
Autor:
John P O'Donnell, Ben P Phillips, Yuichi Yagita, Szymon Juszkiewicz, Armin Wagner, Duccio Malinverni, Robert J Keenan, Elizabeth A Miller, Ramanujan S Hegde
Publikováno v:
eLife, Vol 9 (2020)
Approximately 25% of eukaryotic genes code for integral membrane proteins that are assembled at the endoplasmic reticulum. An abundant and widely conserved multi-protein complex termed EMC has been implicated in membrane protein biogenesis, but its m
Externí odkaz:
https://doaj.org/article/687be91ad85d40c6832df01db1cb83cf
Publikováno v:
Nature
Multipass membrane proteins play numerous roles in biology and include receptors, transporters, ion channels, and enzymes(1,2). How multipass proteins are co-translationally inserted and folded at the endoplasmic reticulum (ER) is not well understood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fedb995be2c0d7e5089bbf9846900f7b
https://doi.org/10.1038/s41586-022-05336-2
https://doi.org/10.1038/s41586-022-05336-2
Autor:
Arunkumar Sundaram, Melvin Yamsek, Frank Zhong, Yogesh Hooda, Ramanujan S. Hegde, Robert J. Keenan
Publikováno v:
Nature. 611:167-172
Most membrane proteins are synthesized on endoplasmic reticulum (ER)-bound ribosomes docked at the translocon, a heterogeneous ensemble of transmembrane factors operating on the nascent chain1,2. How the translocon coordinates the actions of these fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d9ebc285b299e16486b8fb097fb2a6
https://doi.org/10.1038/s41586-022-05330-8
https://doi.org/10.1038/s41586-022-05330-8
Publikováno v:
Cell Reports, Vol 21, Iss 13, Pp 3708-3716 (2017)
Members of the evolutionarily conserved Oxa1/Alb3/YidC family mediate membrane protein biogenesis at the mitochondrial inner membrane, chloroplast thylakoid membrane, and bacterial plasma membrane, respectively. Despite their broad phylogenetic distr
Externí odkaz:
https://doaj.org/article/594276cbcbd54010991996a8bc3daa96