Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Robert A Huddart"'
Autor:
Shane Zaidi, Martin McLaughlin, Shreerang A Bhide, Suzanne A Eccles, Paul Workman, Christopher M Nutting, Robert A Huddart, Kevin J Harrington
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35436 (2012)
Heat shock protein 90 (HSP90) is a molecular chaperone responsible for the conformational maintenance of a number of client proteins that play key roles in cell cycle arrest, DNA damage repair and apoptosis following radiation. HSP90 inhibitors exhib
Externí odkaz:
https://doaj.org/article/08a586a1c76b454e94482aefa4f9bc63
Autor:
Tim A.D. Smith, Catharine M.L. West, Nuradh Joseph, Brian Lane, Joely Irlam-Jones, Elisabet More, Hitesh Mistry, Kimberley J. Reeves, Yee Pei Song, Mark Reardon, Peter J. Hoskin, Syed A. Hussain, Helen Denley, Emma Hall, Nuria Porta, Robert A. Huddart, Nick D. James, Ananya Choudhury
Publikováno v:
EBioMedicine, Vol 101, Iss , Pp 105032- (2024)
Summary: Background: BC2001 showed combining chemotherapy (5-FU + mitomycin-C) with radiotherapy improves loco-regional disease-free survival in patients with muscle-invasive bladder cancer (MIBC). We previously showed a 24-gene hypoxia-associated si
Externí odkaz:
https://doaj.org/article/d3a41a7a7af4450b80b677f0486387d4
Autor:
Arlene O. Siefker-Radtke, Andrea Necchi, Se Hoon Park, Jesús García-Donas, Robert A. Huddart, Earle F. Burgess, Mark T. Fleming, Arash Rezazadeh Kalebasty, Begoña Mellado, Sergei Varlamov, Monika Joshi, Ignacio Duran, Scott T. Tagawa, Yousef Zakharia, Keqin Qi, Sydney Akapame, Spyros Triantos, Anne O'Hagan, Yohann Loriot
Publikováno v:
European Urology Open Science, Vol 50, Iss , Pp 1-9 (2023)
Background: Erdafitinib is indicated for the treatment of adults with locally advanced/metastatic urothelial carcinoma and susceptible FGFR3/2 alterations progressing on/after one or more lines of prior platinum-based chemotherapy. Objective: To bett
Externí odkaz:
https://doaj.org/article/859488fb49644ff6bbf4afa1b1012ee4
Autor:
Shaista Hafeez, Mu Koh, Kelly Jones, Amir El Ghzal, James D’Arcy, Pardeep Kumar, Vincent Khoo, Susan Lalondrelle, Fiona McDonald, Alan Thompson, Erica Scurr, Aslam Sohaib, Robert Anthony Huddart
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
ObjectiveThis study aims to determine local treatment response and long-term survival outcomes in patients with localised muscle-invasive bladder cancer (MIBC) patients receiving neoadjuvant chemotherapy (NAC) using diffusion-weighted MRI (DWI) and a
Externí odkaz:
https://doaj.org/article/4b0febd6cc174119bd9bed80e044a450
Autor:
Alexander P.M. Jay, Mohammed Aldiwani, Michael E. O’Callaghan, Adam K. Pearce, Robert A. Huddart, Erik Mayer, Alison H. Reid, David L. Nicol
Publikováno v:
European Urology Open Science, Vol 29, Iss , Pp 82-88 (2021)
Background: Late relapse (LR) of nonseminomatous germ cell tumour (NSGCT) is uncommon, with limited data published. LR is defined as relapse occurring after a disease-free interval of 2 yr. Objective: To review features of NSGCT LR in a UK tertiary c
Externí odkaz:
https://doaj.org/article/943b1047d6314205816946e12420e363
Autor:
Lee Whiteside, Lisa McDaid, Rosie B Hales, John Rodgers, Michael Dubec, Robert A Huddart, Ananya Choudhury, Cynthia L Eccles
Publikováno v:
Journal of Medical Imaging and Radiation Sciences. 53:362-373
This work evaluated the suitability of MR derived sequences for use in online adaptive RT workflows on a 1.5 Tesla (T) MR-Linear Accelerator (MR Linac).Non-patient volunteers were recruited to an ethics approved MR Linac imaging study. Participants a
Autor:
Robert A. Huddart, Alison M. Reid
Publikováno v:
Advances in Urology, Vol 2018 (2018)
Testicular germ cell tumours are the commonest tumours of young men and are broadly managed either as pure seminomas or as ‘nonseminomas’. The management of Stage 1 nonseminomatous germ cell tumours (NSGCTs), beyond surgical removal of the primar
Externí odkaz:
https://doaj.org/article/856df800b3cb4696a9172d1e99731587
Autor:
Syed A Hussain, Jason F Lester, Richard Jackson, Matthew Gornall, Muneeb Qureshi, Anthony Elliott, Simon J Crabb, Robert A Huddart, Naveen Vasudev, Alison J Birtle, Jane Worlding, Nicholas D James, Omi Parikh, Maria Vilarino-Varela, Roberto Alonzi, Mark D Linch, Irbaz B Riaz, James W F Catto, Thomas Powles, Robert J Jones
Background:\ud Recurrence is common after neoadjuvant chemotherapy and radical treatment for muscle-invasive bladder cancer. We investigated the effect of adding nintedanib to neoadjuvant chemotherapy on response and survival in muscle-invasive bladd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32dffbd1f3a7fc686957cee4573e1511
Autor:
Robert A Huddart, Shaista Hafeez, Abdullahi Omar, Alison Jane Birtle, Ka Ching Cheung, Ananya Choudhury, Farshad Foroudi, Hannah Gribble, Clare Griffin, Ann Henry, Ben Hindson, Rebecca Lewis, Duncan McLaren, Helen McNair, Ashok Nikapota, Omi Parikh, Isabel Syndikus, Mohini Anna Varughese, Amanda Webster, Emma Hall
Publikováno v:
Journal of Clinical Oncology. 41:446-446
446 Background: The bladder is a mobile, deformable structure which makes radiotherapy (RT) delivery challenging. Plan of the day (POD) adaptive image guided RT and tumour boost dose escalation can optimise treatment. We aimed to define a feasible, s
Autor:
Dacheng Huo, Robert A Huddart, Fay Helen Cafferty, Laura Murphy, Gordon J. S. Rustin, Syed A Sohaib, Francesca Schiavone, Richard S. Kaplan, Johnathan K Joffe, Mark Sculpher, Saramago Pedro
Publikováno v:
Journal of Clinical Oncology. 41:408-408
408 Background: Risk of radiation exposure from standard computed tomography (CT) surveillance is a major concern in the management of stage I seminoma testis patients. The TRISST randomized trial (NCT00589537) demonstrated that effective monitoring