Zobrazeno 1 - 10
of 1 093
pro vyhledávání: '"Robert A Holt"'
Autor:
Kristina J Weaver, Sonakshi Raju, Rachel A Rucker, Tuhin Chakraborty, Robert A Holt, Scott D Pletcher
Publikováno v:
eLife, Vol 12 (2023)
Hunger is a motivational drive that promotes feeding, and it can be generated by the physiological need to consume nutrients as well as the hedonic properties of food. Brain circuits and mechanisms that regulate feeding have been described, but which
Externí odkaz:
https://doaj.org/article/9400d62edf3b4053b15f60fe7d981d3c
Autor:
Madison Foster, Dean A Fergusson, Terry Hawrysh, Justin Presseau, Natasha Kekre, Stuart Schwartz, Gisell Castillo, Sarah Asad, Grace Fox, Harold Atkins, Kednapa Thavorn, Joshua Montroy, Robert A Holt, Zarah Monfaredi, Manoj M Lalu
Publikováno v:
Research Involvement and Engagement, Vol 6, Iss 1, Pp 1-10 (2020)
Abstract Aim Though patient engagement in clinical research is growing, recent reports suggest few clinical trials report on such activities. To address this gap, we describe our approach to patient engagement in the development of a clinical trial p
Externí odkaz:
https://doaj.org/article/41291d56e02947a0aa68b46ceb1c3cfe
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0262416 (2022)
BackgroundMucosal infiltration by certain bacterial species may contribute to the development and progression of colorectal cancer (CRC). There is considerable variation in reported detection rates in human CRC samples and the extent to which bacteri
Externí odkaz:
https://doaj.org/article/3f1871c3844c4568a5d218f074547d51
Autor:
Pawan K Pandoh, Richard D Corbett, Helen McDonald, Miguel Alcaide, Heather Kirk, Eva Trinh, Simon Haile, Tina MacLeod, Duane Smailus, Steve Bilobram, Andrew J Mungall, Yussanne Ma, Richard A Moore, Robin Coope, Yongjun Zhao, Steven JM Jones, Robert A Holt, Aly Karsan, Ryan D Morin, Marco A Marra
Publikováno v:
BioTechniques, Vol 66, Iss 2, Pp 85-92 (2019)
The analysis of cell-free circulating tumor DNA (ctDNA) is potentially a less invasive, more dynamic assessment of cancer progression and treatment response than characterizing solid tumor biopsies. Standard isolation methods require separation of pl
Externí odkaz:
https://doaj.org/article/f8f9577ca3a1407898403489370a3edf
Autor:
Justin Presseau, Kednapa Thavorn, Joshua Montroy, Natasha Kekre, Gisell Castillo, Sarah Asad, Madison Foster, Terry Hawrysh, Harold Atkins, Stuart Schwartz, Robert A Holt, Raewyn Broady
Publikováno v:
BMJ Open, Vol 11, Iss 3 (2021)
Objectives Bench to bedside translation of groundbreaking treatments like chimeric antigen receptor T (CAR-T) cell therapy depends on patient participation in early phase trials. Unfortunately, many novel therapies fail to be adequately evaluated due
Externí odkaz:
https://doaj.org/article/e15ae9c463df487f90a74d002eadfad4
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract Current tools for functionally profiling T cell receptors with respect to cytotoxic potency and cross-reactivity are hampered by difficulties in establishing model systems to test these proteins in the contexts of different HLA alleles and a
Externí odkaz:
https://doaj.org/article/7e661a7f9e84401eafd2a999f6bce319
Autor:
Spencer D Martin, Scott D Brown, Darin A Wick, Julie S Nielsen, David R Kroeger, Kwame Twumasi-Boateng, Robert A Holt, Brad H Nelson
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155189 (2016)
Due to advances in sequencing technology, somatically mutated cancer antigens, or neoantigens, are now readily identifiable and have become compelling targets for immunotherapy. In particular, neoantigen-targeted vaccines have shown promise in severa
Externí odkaz:
https://doaj.org/article/e6254d0f66804202a0022687d5592a85
Autor:
Lauren Coombe, René L Warren, Shaun D Jackman, Chen Yang, Benjamin P Vandervalk, Richard A Moore, Stephen Pleasance, Robin J Coope, Joerg Bohlmann, Robert A Holt, Steven J M Jones, Inanc Birol
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163059 (2016)
The linked read sequencing library preparation platform by 10X Genomics produces barcoded sequencing libraries, which are subsequently sequenced using the Illumina short read sequencing technology. In this new approach, long fragments of DNA are part
Externí odkaz:
https://doaj.org/article/107d908370d04fc18e8c9470aed74cba
Autor:
Joel Kidman, Rachael M. Zemek, John-William Sidhom, Debora Correa, Nicola Principe, Fezaan Sheikh, Vanessa S. Fear, Catherine A. Forbes, Abha Chopra, Louis Boon, Ayham Zaitouny, Emma de Jong, Robert A. Holt, Matt Jones, Michael J. Millward, Timo Lassmann, Alistair R.R. Forrest, Anna K. Nowak, Mark Watson, Richard A. Lake, W. Joost Lesterhuis, Jonathan Chee
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
ABSTRACTImmune checkpoint therapy (ICT) causes durable tumour responses in a subgroup of patients, but it is not well known how T cell receptor beta (TCRβ) repertoire dynamics contribute to the therapeutic response. Using murine models that exclude
Externí odkaz:
https://doaj.org/article/f60545e051804f9796499b61db90824e
Autor:
Charles N de Leeuw, Frank M Dyka, Sanford L Boye, Stéphanie Laprise, Michelle Zhou, Alice Y Chou, Lisa Borretta, Simone C McInerny, Kathleen G Banks, Elodie Portales-Casamar, Magdalena I Swanson, Cletus A D'Souza, Shannon E Boye, Steven JM Jones, Robert A Holt, Daniel Goldowitz, William W Hauswirth, Wyeth W Wasserman, Elizabeth M Simpson
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
Critical for human gene therapy is the availability of small promoters tools to drive gene expression in a highly specific and reproducible manner. We tackled this challenge by developing human DNA MiniPromoters (MiniPs) using computational biology a
Externí odkaz:
https://doaj.org/article/a4992868fae84ac68f19247787a4fd6f