Cardiovascular Outcomes Associated With Hypoplastic Left Heart Syndrome Versus Other Types of Single Right Ventricle: A Multicenter Study

Autor: Nabil Dib, Nancy Poirier, Michelle Samuel, Sewanou Hermann Honfo, Ali Zaidi, Alexander R. Opotowsky, François‐Pierre Mongeon, Blandine Mondésert, Joseph Kay, Reda Ibrahim, Robert M. Hamilton, Anne Fournier, Susan M. Jameson, Annie Dore, Stephen Cook, Scott Cohen, Marie‐A. Chaix, Craig S. Broberg, Jamil Aboulhosn, Paul Khairy

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 23 (2024)

Background The univentricular heart with a predominant right ventricle morphology (uRV) has been associated with a higher rate of adverse cardiovascular events. It remains to be determined whether the specific type of uRV influences outcomes. Methods

Externí odkaz: https://doaj.org/article/d8d449b45b064626b97e783f82d6accd

A human monoclonal antibody based immunoenzymetric assay to measure Fel d 1 concentrations in cat hair and pelt allergenic extracts

Autor: Ronald L. Rabin, Derek Croote, Aaron Chen, Ekaterina Dobrovolskaia, Joyce Jia Wen Wong, Jessica Grossman, Robert G. Hamilton

Publikováno v: Frontiers in Allergy, Vol 5 (2024)

In the United States, 19 allergen extracts of different specificities are standardized, which means that their potencies are determined in comparison to a US reference standard. For cat allergen extracts, potency is determined by measuring Fel d 1 co

Externí odkaz: https://doaj.org/article/4eef0e774513475a8d0c9caca58591e4

Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysisResearch in context

Autor: James Yarmolinsky, Jamie W. Robinson, Daniela Mariosa, Ville Karhunen, Jian Huang, Niki Dimou, Neil Murphy, Kimberley Burrows, Emmanouil Bouras, Karl Smith-Byrne, Sarah J. Lewis, Tessel E. Galesloot, Lambertus A. Kiemeney, Sita Vermeulen, Paul Martin, Demetrius Albanes, Lifang Hou, Polly A. Newcomb, Emily White, Alicja Wolk, Anna H. Wu, Loïc Le Marchand, Amanda I. Phipps, Daniel D. Buchanan, Sizheng Steven Zhao, Dipender Gill, Stephen J. Chanock, Mark P. Purdue, George Davey Smith, Paul Brennan, Karl-Heinz Herzig, Marjo-Riitta Järvelin, Chris I. Amos, Rayjean J. Hung, Abbas Dehghan, Mattias Johansson, Marc J. Gunter, Kostas K. Tsilidis, Richard M. Martin, Maria Teresa Landi, Victoria Stevens, Ying Wang, Demetrios Albanes, Neil Caporaso, Christopher I. Amos, Sanjay Shete, Heike Bickeböller, Angela Risch, Richard Houlston, Stephen Lam, Adonina Tardon, Chu Chen, Stig E. Bojesen, H-Erich Wichmann, David Christiani, Gadi Rennert, Susanne Arnold, John K. Field, Loic Le Marchand, Olle Melander, Hans Brunnström, Geoffrey Liu, Angeline Andrew, Hongbing Shen, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, M. Dawn Teare, Yun-Chul Hong, Jian-Min Yuan, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Rosalind A. Eeles, Christopher A. Haiman, Zsofia Kote-Jarai, Fredrick R. Schumacher, Sara Benlloch, Ali Amin Al Olama, Kenneth R. Muir, Sonja I. Berndt, David V. Conti, Fredrik Wiklund, Stephen Chanock, Catherine M. Tangen, Jyotsna Batra, Judith A. Clements, Henrik Grönberg, Nora Pashayan, Johanna Schleutker, Stephanie J. Weinstein, Catharine M.L. West, Lorelei A. Mucci, Géraldine Cancel-Tassin, Stella Koutros, Karina Dalsgaard Sørensen, Eli Marie Grindedal, David E. Neal, Freddie C. Hamdy, Jenny L. Donovan, Ruth C. Travis, Robert J. Hamilton, Sue Ann Ingles, Barry S. Rosenstein, Yong-Jie Lu, Graham G. Giles, Robert J. MacInnis, Adam S. Kibel, Ana Vega, Manolis Kogevinas, Kathryn L. Penney, Jong Y. Park, Janet L. Stanfrod, Cezary Cybulski, Børge G. Nordestgaard, Sune F. Nielsen, Hermann Brenner, Christiane Maier, Christopher J. Logothetis, Esther M. John, Manuel R. Teixeira, Susan L. Neuhausen, Kim De Ruyck, Azad Razack, Lisa F. Newcomb, Davor Lessel, Radka Kaneva, Nawaid Usmani, Frank Claessens, Paul A. Townsend, Jose Esteban Castelao, Monique J. Roobol, Florence Menegaux, Kay-Tee Khaw, Lisa Cannon-Albright, Hardev Pandha, Stephen N. Thibodeau, David J. Hunter, Peter Kraft, William J. Blot, Elio Riboli

Publikováno v: EBioMedicine, Vol 100, Iss , Pp 104991- (2024)

Summary: Background: Tumour-promoting inflammation is a “hallmark” of cancer and conventional epidemiological studies have reported links between various inflammatory markers and cancer risk. The causal nature of these relationships and, thus, th

Externí odkaz: https://doaj.org/article/76559893532a492cbb3d1275b22f7ce4

Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts

Autor: Allen C. T. Teng, Liyang Gu, Michelle Di Paola, Robert Lakin, Zachary J. Williams, Aaron Au, Wenliang Chen, Neal I. Callaghan, Farigol Hakem Zadeh, Yu-Qing Zhou, Meena Fatah, Diptendu Chatterjee, L. Jane Jourdan, Jack Liu, Craig A. Simmons, Thomas Kislinger, Christopher M. Yip, Peter H. Backx, Robert G. Gourdie, Robert M. Hamilton, Anthony O. Gramolini

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

The intercalated disc (ICD) is a membrane structure of the cardiac muscle involved in normal heart function. Here the authors report that knockdown of the ICD-bound transmembrane protein 65 results in impaired ICD structure, abnormal cardiac electrop

Externí odkaz: https://doaj.org/article/aafde2c6ca28412ea8f19a14b47c1f34

Development, multi-institutional external validation, and algorithmic audit of an artificial intelligence-based Side-specific Extra-Prostatic Extension Risk Assessment tool (SEPERA) for patients undergoing radical prostatectomy: a retrospective cohort study

Autor: Jethro C C Kwong, MD, Adree Khondker, BHSc, Eric Meng, BSc, Nicholas Taylor, BSc, Cynthia Kuk, MSc, Nathan Perlis, MD, Girish S Kulkarni, ProfMD, Robert J Hamilton, MD, Neil E Fleshner, ProfMD, Antonio Finelli, ProfMD, Theodorus H van der Kwast, ProfMD, Amna Ali, BSc, Munir Jamal, MD, Frank Papanikolaou, MD, Thomas Short, MD, John R Srigley, ProfMD, Valentin Colinet, MD, Alexandre Peltier, ProfMD, Romain Diamand, MD, Yolene Lefebvre, MD, Qusay Mandoorah, MD, Rafael Sanchez-Salas, MD, Petr Macek, MD, Xavier Cathelineau, ProfMD, Martin Eklund, ProfPhD, Alistair E W Johnson, DPhil, Andrew Feifer, MD, Alexandre R Zlotta, ProfMD

Publikováno v: The Lancet: Digital Health, Vol 5, Iss 7, Pp e435-e445 (2023)

Summary: Background: Accurate prediction of side-specific extraprostatic extension (ssEPE) is essential for performing nerve-sparing surgery to mitigate treatment-related side-effects such as impotence and incontinence in patients with localised pros

Externí odkaz: https://doaj.org/article/9e48ab8efa664112a1f3da359fa83dba