Zobrazeno 1 - 10
of 476
pro vyhledávání: '"Robert A Gatenby"'
Immunomodulatory and pro-oncologic effects of ketamine and isoflurane anesthetics in a murine model.
Autor:
Dominique Abrahams, Arig Ibrahim-Hashim, Robert S Ackerman, Joel S Brown, Christopher J Whelan, Megan B Garfinkel, Robert A Gatenby, Aaron R Muncey
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0292492 (2023)
IntroductionVolatile and intravenous anesthetics may worsen oncologic outcomes in basic science animal models. These effects may be related to suppressed innate and adaptive immunity, decreased immunosurveillance, and disrupted cellular signaling. We
Externí odkaz:
https://doaj.org/article/89ccfa288f7a45ea995a2eb332830cff
Autor:
Péter Bayer, Robert A Gatenby, Patricia H McDonald, Derek R Duckett, Kateřina Staňková, Joel S Brown
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0261578 (2022)
We propose a model of cancer initiation and progression where tumor growth is modulated by an evolutionary coordination game. Evolutionary games of cancer are widely used to model frequency-dependent cell interactions with the most studied games bein
Externí odkaz:
https://doaj.org/article/7b6a2c89ad884d0d987be3628de097f3
Autor:
Olya Grove, Anders E Berglund, Matthew B Schabath, Hugo J W L Aerts, Andre Dekker, Hua Wang, Emmanuel Rios Velazquez, Philippe Lambin, Yuhua Gu, Yoganand Balagurunathan, Edward Eikman, Robert A Gatenby, Steven Eschrich, Robert J Gillies
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248541 (2021)
[This corrects the article DOI: 10.1371/journal.pone.0118261.].
Externí odkaz:
https://doaj.org/article/92f46502f45b4738906c8ef62e7d448b
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185085 (2017)
To maintain optimal fitness, a cell must balance the risk of inadequate energy reserve for response to a potentially fatal perturbation against the long-term cost of maintaining high concentrations of ATP to meet occasional spikes in demand. Here we
Externí odkaz:
https://doaj.org/article/2006b1f2bb4540e08987d3056d8a55b2
Autor:
Daniel Nichol, Peter Jeavons, Alexander G Fletcher, Robert A Bonomo, Philip K Maini, Jerome L Paul, Robert A Gatenby, Alexander R A Anderson, Jacob G Scott
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 9, p e1004493 (2015)
The increasing rate of antibiotic resistance and slowing discovery of novel antibiotic treatments presents a growing threat to public health. Here, we consider a simple model of evolution in asexually reproducing populations which considers adaptatio
Externí odkaz:
https://doaj.org/article/047a95c5dca345fa8dd3d86260d44965
Autor:
Olya Grove, Anders E Berglund, Matthew B Schabath, Hugo J W L Aerts, Andre Dekker, Hua Wang, Emmanuel Rios Velazquez, Philippe Lambin, Yuhua Gu, Yoganand Balagurunathan, Edward Eikman, Robert A Gatenby, Steven Eschrich, Robert J Gillies
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0118261 (2015)
Two CT features were developed to quantitatively describe lung adenocarcinomas by scoring tumor shape complexity (feature 1: convexity) and intratumor density variation (feature 2: entropy ratio) in routinely obtained diagnostic CT scans. The develop
Externí odkaz:
https://doaj.org/article/13b1772cbf3a4946950996c2a1572661
Autor:
Daniel Verduzco, Mark Lloyd, Liping Xu, Arig Ibrahim-Hashim, Yoganand Balagurunathan, Robert A Gatenby, Robert J Gillies
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120958 (2015)
Hypoxia in tumors correlates with greater risk of metastases, increased invasiveness, and resistance to systemic and radiation therapy. The evolutionary dynamics that links specific adaptations to hypoxia with these observed tumor properties have not
Externí odkaz:
https://doaj.org/article/1ddf4165742f49189bf716c4aea4155b
Publikováno v:
Frontiers in Oncology, Vol 3 (2013)
We apply competition colonization tradeoff models to tumor growth and invasion dynamics to explore the hypothesis that varying selection forces will result in predictable phenotypic differences in cells at the tumor invasive front compared to those i
Externí odkaz:
https://doaj.org/article/58ad2f02e3574e30a0a8b24aaf8e11e1
Autor:
Holger Perfahl, Helen M Byrne, Tingan Chen, Veronica Estrella, Tomás Alarcón, Alexei Lapin, Robert A Gatenby, Robert J Gillies, Mark C Lloyd, Philip K Maini, Matthias Reuss, Markus R Owen
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e14790 (2011)
We investigate a three-dimensional multiscale model of vascular tumour growth, which couples blood flow, angiogenesis, vascular remodelling, nutrient/growth factor transport, movement of, and interactions between, normal and tumour cells, and nutrien
Externí odkaz:
https://doaj.org/article/7c38252c1ae64071ac049093438893c7
Autor:
B Roy Frieden, Robert A Gatenby
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22085 (2011)
Living systems use information and energy to maintain stable entropy while far from thermodynamic equilibrium. The underlying first principles have not been established.We propose that stable entropy in living systems, in the absence of thermodynamic
Externí odkaz:
https://doaj.org/article/d15eb459044a4deca813b1f8965437fd