Zobrazeno 1 - 10
of 443
pro vyhledávání: '"Robert A Cross"'
Autor:
Courtney Woolsey, Robert W. Cross, Abhishek N. Prasad, Krystle N. Agans, Viktoriya Borisevich, Daniel J. Deer, Natalie S. Dobias, Alyssa C. Fears, Mack B. Harrison, Megan L. Heinrich, Karla A. Fenton, Robert F. Garry, Luis M. Branco, Thomas W. Geisbert
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
ABSTRACTLassa virus (LASV) is a World Health Organization (WHO) priority pathogen that causes high morbidity and mortality. Recently, we showed that a combination of three broadly neutralizing human monoclonal antibodies known as Arevirumab-3 (8.9F,
Externí odkaz:
https://doaj.org/article/055f26a5860147ff8cc66a9db9b3c6b4
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30738 (2012)
The kinesins-8 were originally thought to be microtubule depolymerases, but are now emerging as more versatile catalysts of microtubule dynamics. We show here that S. pombe Klp5-436 and Klp6-440 are non-processive plus-end-directed motors whose in vi
Externí odkaz:
https://doaj.org/article/08f0e54cb3c84de9927429210b84e2cc
Autor:
Barry J Grant, Dana M Gheorghe, Wenjun Zheng, Maria Alonso, Gary Huber, Maciej Dlugosz, J Andrew McCammon, Robert A Cross
Publikováno v:
PLoS Biology, Vol 9, Iss 11, p e1001207 (2011)
The minimum motor domain of kinesin-1 is a single head. Recent evidence suggests that such minimal motor domains generate force by a biased binding mechanism, in which they preferentially select binding sites on the microtubule that lie ahead in the
Externí odkaz:
https://doaj.org/article/24ebc1a931464eb2bb03d0c509f23df4
Autor:
Yean Ming Chew, Robert A. Cross
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract Taxol is a small molecule effector that allosterically locks tubulin into the microtubule lattice. We show here that taxol has different effects on different single-isotype microtubule lattices. Using in vitro reconstitution, we demonstrate
Externí odkaz:
https://doaj.org/article/c66b6eabede4475daaa507fc7552cd28
Autor:
Robert W. Cross, Abhishek N. Prasad, Courtney B. Woolsey, Krystle N. Agans, Viktoriya Borisevich, Natalie S. Dobias, Jason E. Comer, Daniel J. Deer, Joan B. Geisbert, Angela L. Rasmussen, Walter Ian Lipkin, Karla A. Fenton, Thomas W. Geisbert
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Transmission of Ebola virus (EBOV) primarily occurs via contact exposure of mucosal surfaces with infected body fluids. Historically, nonhuman primate (NHP) challenge studies have employed intramuscular (i.m.) or small particle aerosol expos
Externí odkaz:
https://doaj.org/article/e50fc8bae44c4bac9ac933f1779af9f9
Autor:
Courtney Woolsey, Alyssa C. Fears, Viktoriya Borisevich, Krystle N. Agans, Natalie S. Dobias, Abhishek N. Prasad, Daniel J. Deer, Joan B. Geisbert, Karla A. Fenton, Thomas W. Geisbert, Robert W. Cross
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 1635-1646 (2022)
Due to its high mortality rate and continued re-emergence, Ebolavirus disease (EVD) continues to pose a serious threat to global health. A group of viruses within the genus Ebolavirus causes this severe hemorrhagic disease in humans: Ebola virus (EBO
Externí odkaz:
https://doaj.org/article/4ba14efe32f140fb83a7c614da4e3f7b
Autor:
Robert W. Cross, Christopher M. Wiethoff, Patricia Brown-Augsburger, Shawn Berens, Jamie Blackbourne, Ling Liu, Xiaohua Wu, Jonathan Tetreault, Carter Dodd, Ramtin Sina, Derrick R. Witcher, Deanna Newcomb, Denzil Frost, Angela Wilcox, Viktoriya Borisevich, Krystle N. Agans, Courtney Woolsey, Abhishek N. Prasad, Daniel J. Deer, Joan B. Geisbert, Natalie S. Dobias, Karla A. Fenton, Beth Strifler, Philip Ebert, Richard Higgs, Anne Beall, Sumit Chanda, Laura Riva, Xin Yin, Thomas W. Geisbert
Publikováno v:
Pathogens, Vol 12, Iss 12, p 1408 (2023)
As part of the non-clinical safety package characterizing bamlanivimab (SARS-CoV-2 neutralizing monoclonal antibody), the risk profile for antibody-dependent enhancement of infection (ADE) was evaluated in vitro and in an African green monkey (AGM) m
Externí odkaz:
https://doaj.org/article/f7f4761387234185a8923bd4c6b15ef6
Autor:
Courtney Woolsey, Viktoriya Borisevich, Alyssa C. Fears, Krystle N. Agans, Daniel J. Deer, Abhishek N. Prasad, Rachel O’Toole, Stephanie L. Foster, Natalie S. Dobias, Joan B. Geisbert, Karla A. Fenton, Robert W. Cross, Thomas W. Geisbert
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 3 (2023)
The emergence of the novel henipavirus, Langya virus, received global attention after the virus sickened over three dozen people in China. There is heightened concern that henipaviruses, as respiratory pathogens, could spark another pandemic, most no
Externí odkaz:
https://doaj.org/article/6fae00c584d04cfdac053badea1f2c59
Autor:
Moushimi Amaya, Randy Yin, Lianying Yan, Viktoriya Borisevich, Bishwo N. Adhikari, Andrew Bennett, Francisco Malagon, Regina Z. Cer, Kimberly A. Bishop-Lilly, Antony S. Dimitrov, Robert W. Cross, Thomas W. Geisbert, Christopher C. Broder
Publikováno v:
Viruses, Vol 15, Iss 5, p 1077 (2023)
The henipaviruses, Nipah virus (NiV), and Hendra virus (HeV) can cause fatal diseases in humans and animals, whereas Cedar virus is a nonpathogenic henipavirus. Here, using a recombinant Cedar virus (rCedV) reverse genetics platform, the fusion (F) a
Externí odkaz:
https://doaj.org/article/335eab983bc343c08d5dd66d42df9af6
Autor:
Courtney Woolsey, Robert W Cross, Krystle N Agans, Viktoriya Borisevich, Daniel J Deer, Joan B Geisbert, Cheryl Gerardi, Theresa E Latham, Karla A Fenton, Michael A Egan, John H Eldridge, Thomas W Geisbert, Demetrius Matassov
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 5, p e0010433 (2022)
BackgroundMarburg virus (MARV), an Ebola-like virus, remains an eminent threat to public health as demonstrated by its high associated mortality rate (23-90%) and recent emergence in West Africa for the first time. Although a recombinant vesicular st
Externí odkaz:
https://doaj.org/article/03f5f518f8bc426ba64de4f125e7cfd9