Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Robert A Colbert"'
Autor:
Fatemeh Navid, Tejpal Gill, Lilah Fones, Jules D. Allbritton-King, Kelly Zhou, Isabel Shen, Jinny Van Doorn, Francesca LiCausi, Antony Cougnoux, Davide Randazzo, Stephen R. Brooks, Robert A. Colbert
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract HLA-B27 is a major risk factor for spondyloarthritis (SpA), yet the underlying mechanisms remain unclear. HLA-B27 misfolding-induced IL-23, which is mediated by endoplasmic reticulum (ER) stress has been hypothesized to drive SpA pathogenesi
Externí odkaz:
https://doaj.org/article/98d56151e5764ce0a0a57ba4b073e5cc
Autor:
Phoebe Lin, Mary Bach, Mark Asquith, Aaron Y Lee, Lakshmi Akileswaran, Patrick Stauffer, Sean Davin, Yuzhen Pan, Eric D Cambronne, Martha Dorris, Justine W Debelius, Christian L Lauber, Gail Ackermann, Yoshiki V Baeza, Tejpal Gill, Rob Knight, Robert A Colbert, Joel D Taurog, Russell N Van Gelder, James T Rosenbaum
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105684 (2014)
The HLA-B27 gene is a major risk factor for clinical diseases including ankylosing spondylitis, acute anterior uveitis, reactive arthritis, and psoriatic arthritis, but its mechanism of risk enhancement is not completely understood. The gut microbiom
Externí odkaz:
https://doaj.org/article/1539fbec0dfc48e0bba9fcc7d90d0cc9
Autor:
Hemalatha Srinivasalu, Erin Brennan Treemarcki, Dax G. Rumsey, Pamela F. Weiss, Robert A. Colbert
Publikováno v:
The Journal of Rheumatology. 50:532-537
ObjectiveTo validate the Juvenile Spondyloarthritis Disease Activity Index (JSpADA), and modified versions thereof, in a North American cohort of patients with enthesitis-related arthritis (ERA).MethodsWe utilized the Childhood Arthritis and Rheumato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae59a870040c3109cf537feba9e88532
https://doi.org/10.3899/jrheum.220509
https://doi.org/10.3899/jrheum.220509
Autor:
Laura E. Schanberg, Lily (Yeruk) Mulugeta, Bolanle Akinlade, Hermine I. Brunner, Jianmeng Chen, Robert A. Colbert, Vincent Delgaizo, Marc R. Gastonguay, Rachel Glaser, Lisa Imundo, Daniel J. Lovell, Jocelyn H. Leu, Nael M. Mostafa, Robert M. Nelson, Peter A. Nigrovic, Nikolay P. Nikolov, Lisa G. Rider, Rebecca Rothwell, Chandrahas Sahajwalla, Renu Singh, Vikram Sinha, Carolyn L. Yancey, Lynne Yao
Publikováno v:
Arthritis & Rheumatology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42ccce1811effae897137b13f08f7027
https://doi.org/10.1002/art.42534
https://doi.org/10.1002/art.42534
Autor:
Robert C. Fuhlbrigge, Daniel J. Lovell, Pamela F. Weiss, Robert A. Colbert, Emily von Scheven, Hermine I. Brunner
Publikováno v:
Arthritis Care & Research. 74:1058-1064
This review will summarize clinical, genetic and pathophysiologic characteristics that are shared between children with enthesitis related arthritis (ERA) with axial involvement and adults with non-radiographic, and in some cases radiographic, axial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90e52df832c1eb90d7346422ecc4e45e
https://doi.org/10.1002/acr.24529
https://doi.org/10.1002/acr.24529
Autor:
Wanxia L. Tsai, Robert A. Colbert, Marcus Y Chen, Arlene Sirajuddin, Ryan S. Laird, Peter C. Grayson, Patrycja Hoffmann, Sinisa Savic, Marcela A. Ferrada, Emma M. Groarke, Kristina V. Wells, Massimo Gadina, Bhavisha A Patel, Mariana J. Kaplan, Keith A. Sikora, Emily Rose, Lorena Wilson, Daniel L. Kastner, Gustaf Wigerblad, Zuoming Deng, Amanda K. Ombrello, Oskar Schnappauf, Emily Rominger, Kaitlin A. Quinn, Daniela Ospina Cardona, Jeff Kim, Ivona Aksentijevich, Neal S. Young, David B. Beck, Wendy Goodspeed, Clint T. Allen, Mimi T. Le, Katherine R. Calvo, Yiming Luo, Anne Jones
Publikováno v:
Arthritis & Rheumatology. 73:1886-1895
Objective Somatic mutations in UBA1 cause a newly defined syndrome known as VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic syndrome). More than 50% of patients currently identified as having VEXAS met diagnostic criteria for relapsin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37447f01621cbbbfbba7098afa3da792
https://doi.org/10.1002/art.41743
https://doi.org/10.1002/art.41743
Autor:
Tri M. Tran, Tejpal Gill, Joshua Bennett, Sohee Hong, Vance Holt, Anders J. Lindstedt, Sufia Bakshi, Keith Sikora, Joel D. Taurog, Maxime Breban, Fatemeh Navid, Robert A. Colbert
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.)REFERENCES.
We undertook this study to examine the functional basis for epistasis between endoplasmic reticulum aminopeptidase 1 (ERAP1) and HLA-B27 in experimental spondyloarthritis (SpA).ERAP1-knockout rats were created using genome editing and bred with HLA-B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d71714db59978b7505af6597bea62fe9
https://pubmed.ncbi.nlm.nih.gov/36577442
https://pubmed.ncbi.nlm.nih.gov/36577442
Publikováno v:
Rheumatology (Oxford)
Several cytokines involved in inflammatory pathologies signal via the Janus kinase-signal transducer and activator of transcription pathway. Four JAKs are known: JAK1, JAK2, JAK3 and TYK2. The specific activation of JAKs and STATs determines the biol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe103760d12caafc7ad2c89d4045b054
https://doi.org/10.1093/rheumatology/keab024
https://doi.org/10.1093/rheumatology/keab024
Autor:
V. Michael Holers, Nicolino Ruperto, Rae S. M. Yeung, Alberto Martini, Robert A. Colbert, Peter A. Nigrovic, Seza Ozen, Lucy R. Wedderburn, Susan D. Thompson
Publikováno v:
Nature Reviews Rheumatology. 17:257-269
Chronic inflammatory arthritis in childhood is heterogeneous in presentation and course. Most forms exhibit clinical and genetic similarity to arthritis of adult onset, although at least one phenotype might be restricted to children. Nevertheless, pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bd38f1171267097e2b6907f2bd95340
https://doi.org/10.1038/s41584-021-00590-6
https://doi.org/10.1038/s41584-021-00590-6
Autor:
Jianliang Xu, Robert A. Colbert, Martina Turroja, Fabian Schmidt, Jenna Ariel Lieberman, Roshni Patel, Yiska Weisblum, Justin Da Silva, Irina Shimeliovich, Kathryn E. Huey-Tubman, Zijun Wang, Marina Caskey, Thiago Y. Oliveira, Theodora Hatziioannou, Michel C. Nussenzweig, Cecille Unson-O'Brien, Morgan E. Abernathy, Christian Gaebler, Arlene Hurley, Melissa Cipolla, Rafael Casellas, Zhi Yang, Frauke Muecksch, Juan Dizon, Christopher O. Barnes, Kamille A. West, Anna Gazumyan, Katrina G. Millard, Shlomo Finkin, Victor A. Ramos, Paul D. Bieniasz, Pamela J. Bjorkman, Dennis Schaefer-Babajew, Kristie Gordon
Publikováno v:
bioRxiv
Signal Transduction and Targeted Therapy
Nature
Signal Transduction and Targeted Therapy
Nature
To date severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected over 100 million individuals resulting in over two million deaths. Many vaccines are being deployed to prevent coronavirus disease 2019 (COVID-19) including two novel m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afdccbb2e04218d82b6e8fac7d072289
https://doi.org/10.1038/s41586-021-03324-6
https://doi.org/10.1038/s41586-021-03324-6