Retrospective examination of pseudoprogression in IDH mutant gliomas

Autor: Ethan A Wetzel, Matthew J Farrell, Blaine S C Eldred, Vicki Liu, Ishan Saha, Serendipity Zapanta Rinonos, Terry Prins, Tie Li, Minsong Cao, John Hegde, Tania Kaprealian, Negar Khanlou, Linda M Liau, Phioanh Leia Nghiemphu, Timothy Francis Cloughesy, Robert A Chong, Benjamin M Ellingson, Albert Lai

Publikováno v: Neuro-Oncology Advances. 5

Background Tumor surveillance of isocitrate dehydrogenase (IDH) mutant gliomas is accomplished via serial contrast MRI. When new contrast enhancement (CEnew) is detected during postsurgical surveillance, clinicians must assess whether CEnew indicates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f2d6d4c6168479d989a231f05bdea5b0
https://doi.org/10.1093/noajnl/vdad028

MELAS: Monitoring treatment with magnetic resonance spectroscopy

Autor: Alexandra Galati, Robert A. Chong, Rajarshi Mazumder, Christopher M. DeGiorgio, Shri K. Mishra, Catherine Yim, Dominic A. Hovsepian

Publikováno v: Acta Neurologica Scandinavica. 139:82-85

Background To assess the utility of Magnetic Resonance Spectroscopy (MRS) as a biomarker of response to L-arginine in mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS). Aims To describe a case of MELAS treated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bffd5c808b54c36bc642e9c887d51295
https://doi.org/10.1111/ane.13027

Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination

Autor: Jerry E. Chipuk, Lan Huang, Yingying Yang, Robert A. Chong, Ming Xu, Gary S. Shaw, Brian D. Brown, Zhen-Qiang Pan, Donald E. Spratt, Chan Lee, Inger Tappin, Roberto Sanchez, Jerard Hurwitz, Zhijian J. Chen, Jessica Li, Jaladhi Nayak, Rana Elkholi, Kenneth K. Wu

Publikováno v: Chong, RA; Wu, K; Spratt, DE; Yang, Y; Lee, C; Nayak, J; et al.(2014). Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination. Proceedings of the National Academy of Sciences of the United States of America, 111(23), 8434-8439. doi: 10.1073/pnas.1407849111. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/466015fs

Lysine 48 (K48)-polyubiquitination is the predominant mechanism for mediating selective protein degradation, but the underlying molecular basis of selecting ubiquitin (Ub) K48 for linkage-specific chain synthesis remains elusive. Here, we present bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9505b513c840657df967b4edddecfb7
https://doi.org/10.1073/pnas.1407849111

Suramin inhibits cullin-RING E3 ubiquitin ligases

Autor: Jin Bai, Kenneth Wu, Inger Tappin, Zhen-Qiang Pan, Ning Zheng, Junnian Zheng, Jerard Hurwitz, Donald E. Spratt, Kevin Ching, Chan Lee, Haibin Miao, Robert A. Chong, Dan P. Felsenfeld, Yi Sun, Qing Yu, Gary S. Shaw, Roberto Sanchez

Publikováno v: Proceedings of the National Academy of Sciences. 113

Cullin-RING E3 ubiquitin ligases (CRL) control a myriad of biological processes by directing numerous protein substrates for proteasomal degradation. Key to CRL activity is the recruitment of the E2 ubiquitin-conjugating enzyme Cdc34 through electros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a314e314b9a427363ac4f06dbfcb678a
https://doi.org/10.1073/pnas.1601089113

Generation of a proteolytic signal: E3/E2-mediated polyubiquitination of IκBα

Autor: Robert A, Chong, Kenneth, Wu, Jordan, Kovacev, Zhen-Qiang, Pan

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1280

A key regulatory node in NF-κB signaling is the removal of the IκBα inhibitor, whose levels are tightly controlled by the ubiquitin-proteasome system. In response to signal activation and transmission, ubiquitin E1, E2, and E3 enzymes are employed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d0296daf9e5161618d80895caa11e610
https://pubmed.ncbi.nlm.nih.gov/25736759