Zobrazeno 1 - 10
of 303
pro vyhledávání: '"Robert A Casero"'
Autor:
Tracy Murray Stewart, Jackson R Foley, Cassandra E Holbert, Maxim Khomutov, Noushin Rastkari, Xianzun Tao, Alex R Khomutov, R Grace Zhai, Robert A Casero Jr
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp n/a-n/a (2023)
Abstract Snyder–Robinson syndrome (SRS) results from mutations in spermine synthase (SMS), which converts the polyamine spermidine into spermine. Affecting primarily males, common manifestations of SRS include intellectual disability, osteoporosis,
Externí odkaz:
https://doaj.org/article/5cc8bb3c21394af3a39b11fa46178f84
Autor:
Tracy Murray-Stewart, Matthew Dunworth, Yuan Lui, Francis M Giardiello, Patrick M Woster, Robert A Casero
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202677 (2018)
Curcumin, a natural polyphenol that contributes to the flavor and yellow pigment of the spice turmeric, is known for its antioxidant, anti-inflammatory, and anticarcinogenic properties. Capable of affecting the initiation, promotion, and progression
Externí odkaz:
https://doaj.org/article/7b4ab5d402b44a759a12260a54461949
Autor:
Tracy Murray-Stewart, Elena Ferrari, Ying Xie, Fei Yu, Laurence J Marton, David Oupicky, Robert A Casero
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0178102 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0175917.].
Externí odkaz:
https://doaj.org/article/0d46307286994a9b96a2e3ed61ba3387
Autor:
Kamyar Zahedi, Sharon Barone, Christina Destefano-Shields, Marybeth Brooks, Tracy Murray-Stewart, Matthew Dunworth, Weimin Li, Joanne R Doherty, Mark A Hall, Roger D Smith, John L Cleveland, Robert A Casero, Manoocher Soleimani
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184570 (2017)
Cisplatin-induced nephrotoxicity limits its use in many cancer patients. The expression of enzymes involved in polyamine catabolism, spermidine/spermine N1-acetyltransferase (SSAT) and spermine oxidase (SMOX) increase in the kidneys of mice treated w
Externí odkaz:
https://doaj.org/article/1e3a8c94360248df90771470467f9e57
Autor:
Tracy Murray-Stewart, Elena Ferrari, Ying Xie, Fei Yu, Laurence J Marton, David Oupicky, Robert A Casero
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175917 (2017)
Synthesizing polycationic polymers directly from existing drugs overcomes the drug-loading limitations often associated with pharmacologically inert nanocarriers. We recently described nanocarriers formed from a first-generation polyamine analogue, b
Externí odkaz:
https://doaj.org/article/bb99cdd867ba49acb4ce1c6c0927efe0
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Cellular proliferation, function and survival is reliant upon maintaining appropriate intracellular polyamine levels. Due to increased metabolic needs, cancer cells elevate their polyamine pools through coordinated metabolism and uptake. Hig
Externí odkaz:
https://doaj.org/article/fa46c4e9d60a406cbd62b256f2e5d9bd
Autor:
Xianzun Tao, Jiaqi Liu, Zoraida Diaz-Perez, Jackson R. Foley, Ashley Nwafor, Tracy Murray Stewart, Robert A. Casero, R. Grace Zhai
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-10 (2024)
Abstract Precise polyamine metabolism regulation is vital for cells and organisms. Mutations in spermine synthase (SMS) cause Snyder–Robinson intellectual disability syndrome (SRS), characterized by significant spermidine accumulation and autophagy
Externí odkaz:
https://doaj.org/article/df16f6f1f6604cb3868b67740e22aee2
Autor:
Kamyar Zahedi, Sharon Barone, Yang Wang, Tracy Murray-Stewart, Prabir Roy-Chaudhury, Roger D Smith, Robert A Casero, Manoocher Soleimani
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e110161 (2014)
Expression and activity of spermidine/spermine N1-acetyltransferase (SSAT) increases in kidneys subjected to ischemia/reperfusion (I/R) injury, while its ablation reduces the severity of such injuries. These results suggest that increased SSAT levels
Externí odkaz:
https://doaj.org/article/e3a05719ed094628a8b9a0d60d786a4d
Autor:
Oluwaseun Akinyele, Anushe Munir, Marie A. Johnson, Megan S. Perez, Yuan Gao, Jackson R. Foley, Ashley Nwafor, Yijen Wu, Tracy Murray-Stewart, Robert A. Casero, Hülya Bayir, Dwi U. Kemaladewi
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 6 (2024)
Externí odkaz:
https://doaj.org/article/97fb027069a74c2b824600638dca6afa
Autor:
Lori A Coburn, Xue Gong, Kshipra Singh, Mohammad Asim, Brooks P Scull, Margaret M Allaman, Christopher S Williams, Michael J Rosen, M Kay Washington, Daniel P Barry, M Blanca Piazuelo, Robert A Casero, Rupesh Chaturvedi, Zhongming Zhao, Keith T Wilson
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33546 (2012)
Inflammatory bowel disease (IBD), consisting of Crohn's disease and ulcerative colitis (UC), results in substantial morbidity and is difficult to treat. New strategies for adjunct therapies are needed. One candidate is the semi-essential amino acid,
Externí odkaz:
https://doaj.org/article/533feca6ab3b4bd2a33c8baf8209e8b6