Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Robert A Budinsky"'
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0127952 (2015)
A stochastic model of nuclear receptor-mediated transcription was developed based on activation of the aryl hydrocarbon receptor (AHR) by 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and subsequent binding the activated AHR to xenobiotic response elements
Externí odkaz:
https://doaj.org/article/8575df5f2d804c5389c56fe8817d65b7
Publikováno v:
The Journal of the Acoustical Society of America. 153:A52-A52
Hearing aid processing is designed to improve audibility for sounds of interest, often by targeting external speech signals. During natural conversation, however, the hearing aid user is also the source of speech, potentially interacting with hearing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31d6a7b6d5481f91626a391be2e1be7c
https://doi.org/10.1121/10.0018132
https://doi.org/10.1121/10.0018132
Autor:
Janice K. Britt, Caroline Ring, Daniele Wikoff, Robert A. Budinsky, Jonathan D. Urban, Laurie C. Haws, Seneca Fitch
Publikováno v:
Toxicological Sciences. 179:162-182
Regulatory agencies have derived noncancer toxicity values for 2,3,7,8-tetrachlorodibenzo-p-dioxin based on reduced sperm counts relying on single studies from a large body of evidence. Techniques such as meta-regression allow for greater use of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecbc176ed4cb63d88b92d73df6be243d
https://doi.org/10.1093/toxsci/kfaa171
https://doi.org/10.1093/toxsci/kfaa171
Autor:
John M. DeSesso, Lynn H. Pottenger, Robert A. Budinsky, Raymond G York, James S. Bus, Pragati S. Coder, Joelle M Lucarell, Christopher Bevan, Shiladitya Sen
Publikováno v:
Birth Defects Research
Background Trichloroethylene (TCE) was negative for developmental toxicity after inhalation and oral gavage exposure of pregnant rats but fetal cardiac defects were reported following drinking water exposure throughout gestation. Because of the defic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237ef13da313d1dd1768aba3f3c0fdbe
http://europepmc.org/articles/PMC7432160
http://europepmc.org/articles/PMC7432160
Autor:
Joanna Klapacz, Richard C. Pleus, Matthew J. LeBaron, Lisa M. Corey, Robert A. Budinsky, James Crissman, Rachel M. Golden, Mark Lafranconi
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 119
Studies demonstrate that with sufficient dose and duration, 1,4-dioxane (1,4-DX) induces liver tumors in laboratory rodent models. The available evidence aligns with a threshold-dependent, tumor promotion mode of action (MOA). The MOA and key events
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745bf5f74f7bf096d00ffc0fc5be03b8
https://pubmed.ncbi.nlm.nih.gov/33189748
https://pubmed.ncbi.nlm.nih.gov/33189748
Autor:
Raymond G York, Joelle M Lucarell, John M. DeSesso, James S. Bus, Christopher Bevan, Lynn H. Pottenger, Robert A. Budinsky, Shiladitya Sen, Pragati S. Coder
Publikováno v:
Birth Defects Research. 111:1237-1239
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3547ca07a3123486f4bbd9ed77b1da4
https://doi.org/10.1002/bdr2.1577
https://doi.org/10.1002/bdr2.1577
Autor:
Robert A. Budinsky, Matthew W. Koehler, Wade T. Barranco, Hua Shen, Erik K. Rushton, Christopher R. Kirman, M. Sue Marty, Neeraja Erraguntla, Colin M. North, Stuart Z. Cagen
Publikováno v:
Regulatory Toxicology and Pharmacology. 127:105066
1,3 Butadiene (BD) is an industrial intermediate used primarily in product manufacturing with the greatest exposure potential via inhalation. BD was evaluated for reproductive and developmental effects in a Good Laboratory Practice (GLP)-compliant, e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec02b1edabc957e355a06638ea97f7b4
https://doi.org/10.1016/j.yrtph.2021.105066
https://doi.org/10.1016/j.yrtph.2021.105066
Autor:
Craig Formby, Nathan C. Higgins, Roger P. Juneau, David A. Eddins, Steve Armstrong, Robert A Budinsky
Publikováno v:
The Journal of the Acoustical Society of America. 150:A261-A261
Earplug attenuation depends on developing and maintaining an acoustic seal between the earplug and the walls of the ear canal. During use, earplugs may lose some of their effectiveness by loosening over time and with activity, thereby compromising th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa02cad3b933217f0b1ed716c3fdeab4
https://doi.org/10.1121/10.0008222
https://doi.org/10.1121/10.0008222
Publikováno v:
Reproductive toxicology (Elmsford, N.Y.). 93
Fetal rat exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) reduces epididymal sperm number involving altered pituitary-testicular hormonal signaling as the proposed mode-of-action (MOA). To evaluate this MOA and compare TCDD to 2,3,7,8-tetrachl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbf3c2cd1be18cb435d9804a45fafd4
https://pubmed.ncbi.nlm.nih.gov/32109520
https://pubmed.ncbi.nlm.nih.gov/32109520
Publikováno v:
Journal of Applied Toxicology
Increasing interest in characterizing risk assessment uncertainty is highlighted by recent recommendations from the National Academy of Sciences. In this paper we demonstrate the utility of applying qualitative and quantitative methods for assessing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04e9a6a8296ca1dfe016672c44a7541
https://pubmed.ncbi.nlm.nih.gov/31257608
https://pubmed.ncbi.nlm.nih.gov/31257608