Zobrazeno 1 - 10
of 972
pro vyhledávání: '"Robert A, West"'
Autor:
Peng V. Wu, Matt Fish, Florette K. Hazard, Chunfang Zhu, Sujay Vennam, Hannah Walton, Dhananjay Wagh, John Coller, Joanna Przybyl, Maurizio Morri, Norma Neff, Robert B. West, Roel Nusse
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Cancers evolve not only through the acquisition and clonal transmission of somatic mutations but also by epigenetic mechanisms that modify cell phenotype. Here, we use histology-guided and spatial transcriptomics to characterize hepatoblasto
Externí odkaz:
https://doaj.org/article/2d94ec01e9d046b7b6d307f07deb9f1b
Autor:
Shadia Ahmed, Joanne Fielding, Catherine E. Porter, Kelsey F. Armitage, Marta Wanat, Chris Bates, Lazarina Engonidou, Robert M. West, Ly-Mee Yu, Ushma Galal, Philip Howard, Christopher C. Butler, Sinisa Savic, Jenny Boards, Sarah Tonkin-Crine, John Parry, Sue A. Pavitt, Jonathan T. Sandoe, on behalf of ALABAMA research team
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Background Use of electronic health records (EHR) to provide real-world data for research is established, but using EHR to deliver randomised controlled trials (RCTs) more efficiently is less developed. The Allergy AntiBiotics And Microbial
Externí odkaz:
https://doaj.org/article/08305baed77e4f57828c9603edde5f43
Autor:
Siri H. Strand, Kathleen E. Houlahan, Vernal Branch, Thomas Lynch, Belén Rivero-Guitiérrez, Bryan Harmon, Fergus Couch, Kristalyn Gallagher, Mark Kilgore, Shi Wei, Angela DeMichele, Tari King, Priscilla McAuliffe, Christina Curtis, Kouros Owzar, Jeffrey R. Marks, Graham A. Colditz, E. Shelley Hwang, Robert B. West
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-15 (2024)
Abstract Background Ductal carcinoma in situ (DCIS) is a non-obligate precursor to invasive breast cancer (IBC). Studies have indicated differences in DCIS outcome based on race or ethnicity, but molecular differences have not been investigated. Meth
Externí odkaz:
https://doaj.org/article/a8fcc0a964614940addf1aa9c93ffeba
Autor:
Paola Cocco, Alison Florence Smith, Kerrie Ann Davies, Christopher Michael Rooney, Robert Michael West, Bethany Shinkins
Publikováno v:
MDM Policy & Practice, Vol 9 (2024)
Background. Target product profiles (TPPs) specify the essential properties tests must have to be able to address an unmet clinical need. Aim. To explore how early economic modeling can help to define TPP specifications based on cost-effectiveness co
Externí odkaz:
https://doaj.org/article/1eb12adda22640548e4d156b8564c80c
Autor:
Xinyue Wang, Liming Li, Xun Jiang, Patrick M. Fry, Robert A. West, Conor A. Nixon, Larry Guan, Thishan D. Karandana G, Ronald Albright, Joshua E. Colwell, Tristan Guillot, Mark D. Hofstadter, Matthew E. Kenyon, Anthony Mallama, Santiago Perez-Hoyos, Agustin Sanchez-Lavega, Amy A. Simon, Daniel Wenkert, Xi Zhang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The global energy budget is pivotal to understanding planetary evolution and climate behaviors. Assessing the energy budget of giant planets, particularly those with large seasonal cycles, however, remains a challenge without long-term obser
Externí odkaz:
https://doaj.org/article/08f31c7e99aa4aca823c6701b3661877
Autor:
Neil Powell, Nicola Jones, Rachel Pollard, Robert M West, Mairead McErlean, Chidanand Hullur, Mamidipudi Thirumala Krishna, Louise Savic, Ron Daniels, Iestyn Williams, Jonathan A T Sandoe, Siraj Misbah, Yogini H Jani, Rashmeet Bhogal, Bee Yean Ng, Kornelija Kildonaviciute, Ariyur Balaji, Louise Dunsmure, Caroline Thomas, Amena Warner
Publikováno v:
BMJ Open Quality, Vol 13, Iss 3 (2024)
Background Over 95% of penicillin allergy labels are inaccurate and may be addressed in low-risk patients using direct oral penicillin challenge (DPC). This study explored the behaviour, attitudes and acceptability of patients, healthcare professiona
Externí odkaz:
https://doaj.org/article/05d323541b3d4d17afe355c16cc1d5ef
Autor:
Norah Alsadhan, Sultana A Alhurishi, Mar Pujades-Rodriguez, Farag Shuweihdi, Cathy Brennan, Robert M West
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background In Saudi Arabia, approximately one-third of colorectal cancer (CRC) patients are diagnosed at an advanced stage. Late diagnosis is often associated with a worse prognosis. Understanding the risk factors for late-stage presentation
Externí odkaz:
https://doaj.org/article/64a1542eaf7a47f98ed4dfd5cfcde7f3
Autor:
Neil Powell, Emma Thomas-Jones, Tamas Szakmany, Susan Hopkins, Jonathan Sandoe, Margaret Ogden, Robert M West, Enitan Carrol, Lucy Brookes-Howell, Philip Pallmann, Bethany Shinkins, Dominick Shaw, Philip Howard, Stacy Todd, Thomas P Hellyer, David G Partridge, Graham Prestwich, Sarah M Gerver, Mahableshwar Albur, Martin Llewelyn, Joanne Euden, Iain J McCullagh, Josie Henley, Ryan Hamilton, Wakunyambo Maboshe, Stuart E Bond, Helena Parsons
Publikováno v:
BMJ Open, Vol 13, Iss 12 (2023)
Objective To explore and model factors affecting antibiotic prescribing decision-making early in the pandemic.Design Semistructured qualitative interview study.Setting National Health Service (NHS) trusts/health boards in England and Wales.Participan
Externí odkaz:
https://doaj.org/article/3fe12ce0a430438f986fe9cc4519332a
Publikováno v:
JMIR Cancer, Vol 9, p e49471 (2023)
BackgroundTo inform the development of an intervention, it is essential to have a well-developed theoretical understanding of how an intervention causes change, as stated in the UK Medical Research Council guidelines for developing complex interventi
Externí odkaz:
https://doaj.org/article/f281080ab87247179f8514a67120b239
Autor:
Sarah Tonkin-Crine, Sinisa Savic, Robert M West, Ly-Mee Yu, Sue Pavitt, Ushma Galal, Christopher C Butler, Marta Wanat, Johanna Cook, Bethany Shinkins, Mina Davoudianfar, Emily Bongard, Philip Howard, Marta Santillo, Jenny Boards, Jonathan A T Sandoe, Ruben Mujica-Mota, Razan Saman, Kelsey Fiona Armitage, Catherine E Porter, Shadia Ahmed, Kate Corfield
Publikováno v:
BMJ Open, Vol 13, Iss 9 (2023)
Introduction Incorrect penicillin allergy records are recognised as an important barrier to the safe treatment of infection and affect an estimated 2.7 million people in England. Penicillin allergy records are associated with worse health outcome and
Externí odkaz:
https://doaj.org/article/fb3989c207db43b5b4991134f8fc2fb5