Zobrazeno 1 - 10
of 527
pro vyhledávání: '"Robert A, Stockley"'
Autor:
Robert A. Stockley, David G. Parr
Publikováno v:
ERJ Open Research, Vol 10, Iss 4 (2024)
The past 60 years have seen multiple publications related to lung disease in α1-antitrypsin deficiency largely reflecting the pathophysiology, biochemical effect and outcomes of augmentation therapy. However, the complexity of disease phenotype and
Externí odkaz:
https://doaj.org/article/5a88707c761e4231b050c16747a2b402
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: Alpha-1 antitrypsin deficiency (AATD) is a genetic condition resulting from mutations in the alpha-1 antitrypsin (AAT) protein, a major systemic antiproteinase, resulting in reduced/no release of AAT, disrupting the proteinase/antiprotein
Externí odkaz:
https://doaj.org/article/6f4233b5a72a4d90af2cf6faacf8a454
Autor:
Robert A. Stockley, Anita Pye, Joshua De Soyza, Alice M. Turner, Marc Miravitlles, the EARCO study investigators
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-8 (2023)
Abstract Background Although bronchiectasis has been recognised as a feature of some patients with Alpha1-Antitrypsin deficiency the prevalence and characteristics are not widely known. We wished to determine the prevalence of bronchiectasis and pati
Externí odkaz:
https://doaj.org/article/2d44dcabf471425ea5704c0287e3155f
Autor:
Mohammed A. Almeshari, Nowaf Y. Alobaidi, Elizabeth Sapey, Robert A. Stockley, James A. Stockley
Publikováno v:
Heliyon, Vol 9, Iss 10, Pp e20744- (2023)
Background: The small airways comprise the largest cross-sectional area of the lungs, however, assessing and reporting abnormalities for this region of the bronchial tree has been practically and scientifically uncertain. Methods: Using routinely col
Externí odkaz:
https://doaj.org/article/97c2e2af4c784a18acf30fbb524c1131
Autor:
Nowaf Y. Alobaidi, Mohammed A. Almeshari, James A. Stockley, Robert A. Stockley, Elizabeth Sapey
Publikováno v:
BMC Pulmonary Medicine, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Background Bronchodilator responsiveness (BDR) using FEV1 is often utilised to separate COPD patients from asthmatics, although it can be present in some COPD patients. With the advent of treatments with distal airway deposition, BDR in the
Externí odkaz:
https://doaj.org/article/fd09357d20704df2a4167f1f2898d99b
Autor:
Elizabeth Sapey, James Stockley, Nowaf Y Alobaidi, Mohammed Almeshari, Robert Andrew Stockley
Publikováno v:
BMJ Open Respiratory Research, Vol 9, Iss 1 (2022)
Background Chronic obstructive pulmonary disease (COPD) is diagnosed and its severity graded by traditional spirometric parameters (forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) and FEV1, respectively) but these parameters are co
Externí odkaz:
https://doaj.org/article/fc93c1f682da4f5788632fd1258baa86
Publikováno v:
Annals of Thoracic Medicine, Vol 15, Iss 2, Pp 54-63 (2020)
Chronic obstructive pulmonary disease (COPD) is common and debilitating. Most patients with COPD experience intermittent, acute deterioration in symptoms which require additional therapy, termed exacerbations. Exacerbations are prevalent in COPD and
Externí odkaz:
https://doaj.org/article/c5477564c4d04c888c26e4f564884965
Autor:
Peymané Adab, Rachel E Jordan, David Fitzmaurice, Jon G Ayres, KK Cheng, Brendan G Cooper, Amanda Daley, Andrew Dickens, Alexandra Enocson, Sheila Greenfield, Shamil Haroon, Kate Jolly, Sue Jowett, Tosin Lambe, James Martin, Martin R Miller, Kiran Rai, Richard D Riley, Steve Sadhra, Alice Sitch, Stanley Siebert, Robert A Stockley, Alice Turner
Publikováno v:
Programme Grants for Applied Research, Vol 9, Iss 13 (2021)
Background: Chronic obstructive pulmonary disease is a major contributor to morbidity, mortality and health service costs but is vastly underdiagnosed. Evidence on screening and how best to approach this is not clear. There are also uncertainties aro
Externí odkaz:
https://doaj.org/article/d5823b1af06247dbbff28d73cde2a65d
Autor:
Iris G.M. Schouten, Marise J. Kasteleyn, Roula Tsonaka, Robert Bals, Alice C. Turner, Ilaria Ferrarotti, Angelo G. Corsico, Beatriz Lara, Marc Miravitlles, Robert A. Stockley, Jan Stolk
Publikováno v:
ERJ Open Research, Vol 7, Iss 3 (2021)
Background Patients with ZZ (Glu342Lys) α-1-antitrypsin deficiency (ZZ-AATD) who received augmentation therapy with α-1-antitrypsin (AAT) in randomised controlled trials over 2–3 years failed to show a significant reduction of the annual decline
Externí odkaz:
https://doaj.org/article/c5c29e735f444343bcd757fbdb5cebf4
Autor:
Chirag Dave, Simon Wharton, Rahul Mukherjee, Bandar M. Faqihi, Robert A. Stockley, Alice M. Turner
Publikováno v:
Canadian Respiratory Journal, Vol 2021 (2021)
Background. Identification of patients who may become hypercapnic, or develop acidotic hypercapnic respiratory failure (AHRF), is important in chronic obstructive pulmonary disease (COPD) to avoid hospital admission and select patients for use of hom
Externí odkaz:
https://doaj.org/article/8d54e9b530e14eafbc84a856bc1f8f54