Dbf4-Dependent Kinase (DDK)-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A in Saccharomyces cerevisiae

Autor: Jessica R. Eisenstatt, Lars Boeckmann, Wei-Chun Au, Valerie Garcia, Levi Bursch, Josefina Ocampo, Michael Costanzo, Michael Weinreich, Robert A. Sclafani, Anastasia Baryshnikova, Chad L. Myers, Charles Boone, David J. Clark, Richard Baker, Munira A. Basrai

Publikováno v: G3: Genes, Genomes, Genetics, Vol 10, Iss 6, Pp 2057-2068 (2020)

The evolutionarily conserved centromeric histone H3 variant (Cse4 in budding yeast, CENP-A in humans) is essential for faithful chromosome segregation. Mislocalization of CENP-A to non-centromeric chromatin contributes to chromosomal instability (CIN

Externí odkaz: https://doaj.org/article/18406182fbf848b19238234c13a0f3b1

Dbf4-dependent kinase (DDK)-mediated proteolysis of CENP-A prevents mislocalization of CENP-A in Saccharomyces cerevisiae

Autor: Michael Weinreich, Lars Boeckmann, Richard Baker, Michael Costanzo, Anastasia Baryshnikova, Josefina Ocampo, Charles Boone, Levi Bursch, Chad L. Myers, Jessica R. Eisenstatt, David Clark, Munira A. Basrai, Valerie Garcia, Wei-Chun Au, Robert A. Sclafani

Publikováno v: G3: Genes, Genomes, Genetics, Vol 10, Iss 6, Pp 2057-2068 (2020)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

The evolutionarily conserved centromeric histone H3 variant (Cse4 in budding yeast, CENP-A in humans) is essential for faithful chromosome segregation. Mislocalization of CENP-A to non-centromeric chromatin contributes to chromosomal instability (CIN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a61c9df8dc3c7a830058a84165e8d48a
https://www.g3journal.org/content/10/6/2057

Localization of Cdc7 Protein Kinase During DNA Replication in Saccharomyces cerevisiae

Autor: Robert A. Sclafani, Daniel Rossbach, Jay R. Hesselberth, D. Suzi Bryan

Publikováno v: G3: Genes|Genomes|Genetics
G3: Genes, Genomes, Genetics, Vol 7, Iss 11, Pp 3757-3774 (2017)

DDK, a conserved serine-threonine protein kinase composed of a regulatory subunit, Dbf4, and a catalytic subunit, Cdc7, is essential for DNA replication initiation during S phase of the cell cycle through MCM2-7 helicase phosphorylation. The biologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f202033e9da1f965d72662ac26bf20be
http://europepmc.org/articles/PMC5677158

The late‐annotated small ORF LSO 1 is a target gene of the iron regulon of Saccharomyces cerevisiae

Autor: Xiuxiang An, Caiguo Zhang, Mingxia Huang, Robert A. Sclafani, Paul A. Seligman

Publikováno v: MicrobiologyOpen

We have identified a new downstream target gene of the Aft1/2‐regulated iron regulon in budding yeast Saccharomyces cerevisiae, the late‐annotated small open reading frame LSO1. LSO1 transcript is among the most highly induced from a transcriptom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500b9635381d2cd46cad29df7cbb3950
https://doi.org/10.1002/mbo3.303

Grape seed extract and resveratrol prevent 4-nitroquinoline 1-oxide induced oral tumorigenesis in mice by modulating AMPK activation and associated biological responses

Autor: David J. Orlicky, Rajesh Agarwal, Gagan Deep, Robert A. Sclafani, Xiao-Jing Wang, Joshua Wisell, Chapla Agarwal, Alpna Tyagi, Sangeeta Shrotriya

Publikováno v: Molecular Carcinogenesis. 54:291-300

Preventive measures against oral carcinogenesis are urgently warranted to lower the high morbidity and mortality associated with this malignancy worldwide. Here, we investigated the chemopreventive efficacy of grape seed extract (GSE) and resveratrol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0bd39061830c35ea4e7ce5d43aea84c6
https://doi.org/10.1002/mc.22099