Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Robert A, Nagourney"'
Autor:
Paulo D’Amora, Ismael D. C. G. Silva, Steven S. Evans, Adam J. Nagourney, Katharine A. Kirby, Brett Herrmann, Daniela Cavalheiro, Federico R. Francisco, Paula J. Bernard, Robert A. Nagourney
Publikováno v:
Metabolites, Vol 14, Iss 3, p 148 (2024)
With 64,050 new diagnoses and 50,550 deaths in the US in 2023, pancreatic ductal adenocarcinoma (PDAC) is among the most lethal of all human malignancies. Early detection and improved prognostication remain critical unmet needs. We applied next-gener
Externí odkaz:
https://doaj.org/article/92f85caaafc846098fff7e5c906d07e4
Autor:
Paulo D'Amora, Ismael Dale C G Silva, Maria Auxiliadora Budib, Ricardo Ayache, Rafaela Moraes Siufi Silva, Fabricio Colacino Silva, Robson Mateus Appel, Saturnino Sarat Júnior, Henrique Budib Dorsa Pontes, Ana Carolina Alvarenga, Emilli Carvalho Arima, Wellington Galhano Martins, Nakal Laurenço F Silva, Ricardo Sobhie Diaz, Marcia B Salzgeber, Anton M Palma, Steven S Evans, Robert A Nagourney
Publikováno v:
PLoS ONE, Vol 16, Iss 12, p e0259909 (2021)
This study investigated the association between COVID-19 infection and host metabolic signatures as prognostic markers for disease severity and mortality. We enrolled 82 patients with RT-PCR confirmed COVID-19 infection who were classified as mild, m
Externí odkaz:
https://doaj.org/article/2d6f9073a84446dca68372ebde0279bf
Autor:
Pedro Luiz Serrano Usón Junior, Jairo Wagner, Marcus Vinicius de Nigro Corpa, Iracema Moraes Coelho, Robert A Nagourney, Nise Hitomi Yamaguchi
Publikováno v:
SAGE Open Medical Case Reports, Vol 7 (2019)
Background: The treatment of carcinoma of unknown primary based on histopathology and immunohistochemistry is generally chemotherapy. The use of molecular markers, genetic profiling platforms, and personalized medicine is under active investigation.
Externí odkaz:
https://doaj.org/article/841d836f44fe4948820c7b545872e08f
Autor:
Adam J. Nagourney, Joshua B. Gipoor, Steven S. Evans, Paulo D’Amora, Max S. Duesberg, Paula J. Bernard, Federico Francisco, Robert A. Nagourney
Publikováno v:
Genes; Volume 14; Issue 3; Pages: 747
Background:TP53 is the most commonly mutated gene in human cancer with loss of function mutations largely concentrated in “hotspots” affecting DNA binding. APR-246 and COTI-2 are small molecules under investigation in P53 mutated cancers. APR bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6abff3dc9cb778e5fb8eeb96892cb9
Autor:
Adam J. Nagourney, Steven S. Evans, Paulo D'Amora, Nise Yamaguchi, Paula Bernard, Federico Francisco, Joshua B. Gipoor, Robert Alan Nagourney
Publikováno v:
Cancer Research. 83:4910-4910
There is growing interest in the use of human tumor primary cultures for the prediction of response to drugs and drug combinations in cancer medicine. While the field has witnessed numerous attempts to apply human tissue for the prediction of respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23f4cc175c3b156e3e824c033f0e4951
https://doi.org/10.1158/1538-7445.am2023-4910
https://doi.org/10.1158/1538-7445.am2023-4910
Autor:
Anton M. Palma, Steven S. Evans, Antônio Augusto Ferreira Carioca, Kristine R. Penner, Marcia Batista Salzgeber, Dirce Maria Lobo Marchioni, Ismael Dale Cotrim Guerreiro da Silva, Fabio Cappuccini, Robert E. Bristow, Jill Alldredge, Teresa C. Longoria, Paulo D'Amora, Robert A. Nagourney, Paula J. Addis-Bernard, Krishnansu S. Tewari
Publikováno v:
Gynecologic oncology. 163(1)
Objective Platinum resistance, defined as the lack of response or relapse within six months of platinum-based chemotherapy, is an important determinant of survival in gynecologic cancer. We used quantitative Mass Spectrometry to identify metabolic si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c19e8bb1bf1f847ddfd031c852b0bff
https://pubmed.ncbi.nlm.nih.gov/34446269
https://pubmed.ncbi.nlm.nih.gov/34446269
Autor:
Adam J. Nagourney, Paulo D'Amora, Ismael Dale Cotrim Guerreiro Silva, Steven S. Evans, Robert A. Nagourney
Publikováno v:
Cancer Research. 82:1965-1965
Ovarian cancer is the leading cause of gynecologic cancer death with over 21,000 new diagnosis and 13,000 deaths each year in the US. Treatment with platinum-based chemotherapy induces remission in up to 80% of patients yet the majority relapse and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e91269edfbcddb7a92cdf5a777221b49
https://doi.org/10.1158/1538-7445.am2022-1965
https://doi.org/10.1158/1538-7445.am2022-1965
Autor:
Adam Jeremiah Nagourney, Paulo D'Amora, Steven Scott Evans, Paula Bernard, Federico Francisco, Young Ko, Thomas Stockwell, Maxine Johnson, Robert Alan Nagourney
Publikováno v:
Cancer Research. 82:4062-4062
Altered metabolism is a hallmark of human malignancy. The “Warburg Effect “reflecting increased glycolytic activity in the presence of oxygen represents an opportunity to target specific features of cancer to induce selective toxicity to malignan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12190ce32cd816915a0db95ace3d3643
https://doi.org/10.1158/1538-7445.am2022-4062
https://doi.org/10.1158/1538-7445.am2022-4062
Autor:
Adam Jeremiah Nagourney, Steven Scott Evans, Max Serge Duesberg, Paulo D'Amora, Paula J. Bernard, Eric Francisco, Robert Alan Nagourney
Publikováno v:
Journal of Clinical Oncology. 40:e15092-e15092
e15092 Background: The TP53 tumor suppressor is the most commonly mutated gene in human cancer. P53 protein comprised of 393 amino acids functions as a tetramer with the loss of function mutations concentrated in “hotspots” that often affect DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c114c565ff00adae02b0445d4b70a97
https://doi.org/10.1200/jco.2022.40.16_suppl.e15092
https://doi.org/10.1200/jco.2022.40.16_suppl.e15092
Publikováno v:
Case Reports in Medicine, Vol 2013 (2013)
Breast cancer occurring in women under the age of 40 is uncommon in the absence of family history or genetic predisposition, and prompts the exploration of other possible exposures or environmental risks. We report a case series of four young women
Externí odkaz:
https://doaj.org/article/c410004eef174c868907a87dbb22b4e1