Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Robert A, Heinzen"'
Autor:
Carrie M. Long, Paul A. Beare, Diane Cockrell, Picabo Binette, Mahelat Tesfamariam, Crystal Richards, Matthew Anderson, Jessica McCormick-Ell, Megan Brose, Rebecca Anderson, Anders Omsland, Talima Pearson, Robert A. Heinzen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-8 (2024)
Abstract Lipopolysaccharide (LPS) phase variation is a critical aspect of virulence in many Gram-negative bacteria. It is of particular importance to Coxiella burnetii, the biothreat pathogen that causes Q fever, as in vitro propagation of this organ
Externí odkaz:
https://doaj.org/article/a0dbc7cdafb446f6aee58d667d80ebc3
Autor:
Doulin C. Shepherd, Mohammed Kaplan, Naveen Vankadari, Ki Woo Kim, Charles L. Larson, Przemysław Dutka, Paul A. Beare, Edward Krzymowski, Robert A. Heinzen, Grant J. Jensen, Debnath Ghosal
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107210- (2023)
Summary: Coxiella burnetii is an obligate zoonotic bacterium that targets macrophages causing a disease called Q fever. It has a biphasic developmental life cycle where the extracellular and metabolically inactive small cell variant (SCV) transforms
Externí odkaz:
https://doaj.org/article/27c86346303a4fe4bee530fa4804c8f2
Autor:
Carrie M. Long, Paul A. Beare, Diane Cockrell, Picabo Binette, Mahelat Tesfamariam, Crystal Richards, Matthew Anderson, Jessica McCormick-Ell, Megan Brose, Rebecca Anderson, Anders Omsland, Talima Pearson, Robert A. Heinzen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/e437619e60f542a9bd7dca538dae0820
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Coxiella burnetii is a Gram-negative pathogen that infects a variety of mammalian hosts. Infection of domesticated ewes can cause fetal abortion, whereas acute human infection normally manifests as the flu-like illness Q fever. Successful ho
Externí odkaz:
https://doaj.org/article/cc47f8ea49ef41f0ac2c6b8bc2397181
Autor:
Carrie M. Long, Paul A. Beare, Diane C. Cockrell, Jonathan Fintzi, Mahelat Tesfamariam, Carl I. Shaia, Robert A. Heinzen
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-14 (2021)
Abstract Coxiella burnetii is the bacterial causative agent of the zoonosis Q fever. The current human Q fever vaccine, Q-VAX®, is a fixed, whole cell vaccine (WCV) licensed solely for use in Australia. C. burnetii WCV administration is associated w
Externí odkaz:
https://doaj.org/article/d0529c4e3ca2440ab6147266ba854488
Autor:
Picabo Binette, Mahelat Tesfamariam, Diane Cockrell, Robert A. Heinzen, Crystal Richards, Carl Shaia, Carrie Mae Long
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Delayed-type hypersensitivity (DTH) responses to microbial vaccines and related components are a major roadblock for widespread licensing of whole cell vaccines such as that of Q fever. Q fever is a zoonotic disease caused by the intracellular bacter
Externí odkaz:
https://doaj.org/article/40965b3ad1cd4dc08074e97550903f06
Autor:
Eric Cheng, Dorjbal Dorjsuren, Stephanie Lehman, Charles L. Larson, Steven A. Titus, Hongmao Sun, Alexey Zakharov, Ganesha Rai, Robert A. Heinzen, Anton Simeonov, Matthias P. Machner
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Bacterial type IV secretion systems (T4SSs) are macromolecular machines that translocate effector proteins across multiple membranes into infected host cells. Loss of function mutations in genes encoding protein components of the T4SS render
Externí odkaz:
https://doaj.org/article/17ea4c8ef25440e6a85c917d59465e91
Autor:
Tatiana M. Clemente, Rochelle Ratnayake, Dhritiman Samanta, Leonardo Augusto, Paul A. Beare, Robert A. Heinzen, Stacey D. Gilk
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Coxiella burnetii replicates in a phagolysosome-like vacuole called the Coxiella-containing vacuole (CCV). While host cholesterol readily traffics to the CCV, cholesterol accumulation leads to CCV acidification and bacterial death. Thus, bac
Externí odkaz:
https://doaj.org/article/d2ba868c300745e8a0de32d5252ccb4a
Autor:
Mahelat Tesfamariam, Picabo Binette, Diane Cockrell, Paul A. Beare, Robert A. Heinzen, Carl Shaia, Carrie Mae Long
Publikováno v:
Microorganisms, Vol 10, Iss 11, p 2261 (2022)
Coxiella burnetii is a Gram-negative, intracellular bacterium that causes the zoonosis Q fever. Among the many natural isolates of C. burnetii recovered from various sources, the Dugway group exhibits unique genetic characteristics, including the lar
Externí odkaz:
https://doaj.org/article/436fc870a8ef454e88cffe2ace597d25
Publikováno v:
Virulence, Vol 10, Iss 1, Pp 133-150 (2019)
Coxiella burnetii is an intracellular, gram-negative bacterium that causes the zoonosis Q fever. This disease typically presents as an acute flu-like illness with persistent, focalized infections occurring less frequently. Clinical outcomes of Q feve
Externí odkaz:
https://doaj.org/article/0b63355c05944c1da3202ca0fb4cdd54