Zobrazeno 1 - 10
of 1 053
pro vyhledávání: '"Robert A, Hegele"'
Genetic Testing for Familial Hypercholesterolemia: The Current State of Its Implementation in Canada
Autor:
Adam I. Kramer, MD, MSc, Susan Christian, MSc, PhD, Kirsten Bartels, MSc, Nicol Vaizman, BS, Robert A. Hegele, MD, Liam R. Brunham, MD, PhD
Publikováno v:
CJC Open, Vol 6, Iss 11, Pp 1395-1402 (2024)
Background: Familial hypercholesterolemia (FH) is a common genetic disorder, yet it remains largely underdiagnosed in Canada. Multiple national and international guidelines recommend the use of clinical genetic testing for FH. However, the level of i
Externí odkaz:
https://doaj.org/article/f49f497e8c9a4d53994a602c3b7ba285
Autor:
Daniel R. Tabet, Da Kuang, Megan C. Lancaster, Roujia Li, Karen Liu, Jochen Weile, Atina G. Coté, Yingzhou Wu, Robert A. Hegele, Dan M. Roden, Frederick P. Roth
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Background Computational variant effect predictors offer a scalable and increasingly reliable means of interpreting human genetic variation, but concerns of circularity and bias have limited previous methods for evaluating and comparing pred
Externí odkaz:
https://doaj.org/article/be0e465c42924e5dbc503b50ed990281
Autor:
Maud Ahmad, Brooke A. Kennedy, Surim Son, Adam D. McIntyre, Julieta Lazarte, Jian Wang, Robert A. Hegele
Publikováno v:
Atherosclerosis Plus, Vol 56, Iss , Pp 7-11 (2024)
Background and aims: Severe hypertriglyceridemia (HTG), defined as plasma triglyceride (TG) concentration > 10 mmol/L, is relatively uncommon, and its implications for atherosclerotic cardiovascular disease (ASCVD) risk remain somewhat unclear. We ev
Externí odkaz:
https://doaj.org/article/dd32439b123c40239fd2e9bf7450cd81
Publikováno v:
Journal of International Medical Research, Vol 52 (2024)
Objective To investigate the relationship between plasma lipoprotein (a) (Lp[a]) and lipid profiles in patients with severe hypertriglyceridaemia (HTG). Methods This case–control study undertook a retrospective chart review of patients from the Lip
Externí odkaz:
https://doaj.org/article/352509eebb0742e28f17672eea0b5983
Autor:
Tiffany Yuen, MD, FRCPC, G.B. John Mancini, MD, FRCPC, FACP, FACC, Robert A. Hegele, MD, FRCPC, Glen J. Pearson, PharmD, FCCS
Publikováno v:
CJC Open, Vol 6, Iss 3, Pp 597-606 (2024)
Lipoprotein(a) (Lp[a]) is an low-density lipoprotein (LDL)-like particle in which apolipoprotein (apo) B is covalently bound to a plasminogen-like molecule called apo(a). A High level of Lp(a) has been demonstrated to be an independent, causal, and p
Externí odkaz:
https://doaj.org/article/54eb1845209e449fa7533480d25e4773
Autor:
Shyann Hang, Robert A. Hegele
Publikováno v:
Journal of International Medical Research, Vol 52 (2024)
Lipoprotein(a) (Lp(a)) is an atherogenic low-density lipoprotein (LDL)-like particle that is currently regarded as a non-modifiable risk factor for atherosclerotic cardiovascular disease. The number of patients detected with elevated Lp(a) concentrat
Externí odkaz:
https://doaj.org/article/6a350aaee5de4ea6bd076ed4e619dc6d
Publikováno v:
CJC Open, Vol 6, Iss 1, Pp 40-46 (2024)
Background: Low density lipoprotein (LDL) and Lipoprotein (Lp)(a) are proatherogenic apolipoprotein (apo) B-containing members of the non–high-density lipoprotein (non-HDL) family of particles. Elevated plasma levels of LDL cholesterol (C), non-HDL
Externí odkaz:
https://doaj.org/article/4f5ddc131a5e4e81acbf0329c221eac6
Autor:
Lawrence A. Leiter, Robert A. Hegele, Vivien Brown, Jean Bergeron, Erin S. Mackinnon, G. B. John Mancini
Publikováno v:
Reviews in Cardiovascular Medicine, Vol 25, Iss 10, p 383 (2024)
Externí odkaz:
https://doaj.org/article/571d110f310246ae8c213f2595e67747
Autor:
Shengjie Ying, Tracy Heung, Bhooma Thiruvahindrapuram, Worrawat Engchuan, Yue Yin, Christina Blagojevic, Zhaolei Zhang, Robert A. Hegele, Ryan K. C. Yuen, Anne S. Bassett
Publikováno v:
BMC Medical Genomics, Vol 16, Iss 1, Pp 1-11 (2023)
Abstract Background Elevated triglyceride (TG) levels are a heritable and modifiable risk factor for cardiovascular disease and have well-established associations with common genetic variation captured in a polygenic risk score (PRS). In young adulth
Externí odkaz:
https://doaj.org/article/e3b86bf5315244c5ade858fc4967c998
Autor:
Daniela Andriuta, Joel Ramirez, Fuqiang Gao, Jennifer Rabin, Madeline E Wood, Paula M McLaughlin, Christopher JM Scott, Miracle Ozzoude, Allison A Dilliott, Robert A Hegele, Maria C Tartaglia, David Tang-Wai, Richard H Swartz, Leanne Casaubon, Sanjeev Kumar, Dar Dowlatshahi, Jennifer Mandzia, Demetrios Sahlas, Gustavo Saposnik, Corinne Fischer, Michael Borrie, Ayman Hassan, Malcolm A Binns, Morris Freedman, Elizabeth Finger, Andrew Frank, Robert Bartha, Sean Symons, Mario Masellis, Sandra E Black
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100292- (2024)
Introduction: MRI-visible perivascular spaces (PVS) are a neuroimaging feature of cerebral small vessel disease and are commonly observed in patients with cerebrovascular and neurodegenerative disease. However, it is unclear whether PVS burden is ass
Externí odkaz:
https://doaj.org/article/3072b8b20a2542edba402451a620a4f6