Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Robert A, Goodnow"'
Autor:
Matthias Zentgraf, Elizabeth Krutoholow, Thomas S. Rush, Chris Luebkemann, Kimito Funatsu, Gisbert Schneider, Jeff Blaney, Alleyn T. Plowright, Norman Sieroka, John Edward Hill, Petra Schneider, Jennifer Listgarten, José S. Duca, Robert Alan Goodnow, Johanna M. Jansen, Jasmin Fisher, Matthias Kohler, W. Patrick Walters
Publikováno v:
Nature Reviews Drug Discovery. 19:353-364
Artificial intelligence (AI) tools are increasingly being applied in drug discovery. While some protagonists point to vast opportunities potentially offered by such tools, others remain sceptical, waiting for a clear impact to be shown in drug discov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53001ef1a373cf62d629543029f92869
https://doi.org/10.1038/s41573-019-0050-3
https://doi.org/10.1038/s41573-019-0050-3
Autor:
Petra, Schneider, W Patrick, Walters, Alleyn T, Plowright, Norman, Sieroka, Jennifer, Listgarten, Robert A, Goodnow, Jasmin, Fisher, Johanna M, Jansen, José S, Duca, Thomas S, Rush, Matthias, Zentgraf, John Edward, Hill, Elizabeth, Krutoholow, Matthias, Kohler, Jeff, Blaney, Kimito, Funatsu, Chris, Luebkemann, Gisbert, Schneider
Publikováno v:
Nature reviews. Drug discovery. 19(5)
Artificial intelligence (AI) tools are increasingly being applied in drug discovery. While some protagonists point to vast opportunities potentially offered by such tools, others remain sceptical, waiting for a clear impact to be shown in drug discov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3b4340fe33dcb827c37bc8bd01eead2f
https://pubmed.ncbi.nlm.nih.gov/31801986
https://pubmed.ncbi.nlm.nih.gov/31801986
Autor:
Thierry Kogej, Ying Zhang, Nidhal Selmi, Robert A. Goodnow, Xia Tian, Matthew Clark, Gregory S. Basarab
Publikováno v:
MedChemComm. 7:1316-1322
The generation of novel chemical leads for clinical development is a constant challenge in the pharmaceutical industry. The synthesis of DNA-encoded libraries has emerged as a powerful method for hit and lead generation. We report the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8021a9e357208f5e112dd4bae914ca1
https://doi.org/10.1039/c6md00088f
https://doi.org/10.1039/c6md00088f
Autor:
Robert A. Goodnow
Platform Technologies in Drug Discovery and Validation, Volume 50, the latest release in the Annual Reports in Medicinal Chemistry series, provides timely and critical reviews of important topics in medicinal chemistry, with an emphasis on emerging t
Autor:
Rebecca Taub, Robert Alan Goodnow, Lida Qi, Joseph Anthony Bilotta, Sherrie Lynn Pietranico-Cole, Yonglin Ren, Cheryl Spence, Jefferson Wright Tilley, Baolian Liu, Sung-Sau So, Kevin Richard Guertin, Karin Conde-Knape, Matthew Michael Hamilton, Nancy-Ellen Haynes, Kshitij Chhabilbhai Thakkar, Catherine Zwingelstein, Nathan Robert Scott, Paul Gillespie, Michael Paul Myers, Nader Fotouhi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2707-2711
Starting from screening hit, (4S,7R)-1,7,8,8-tetramethyl-2-phenyl-1,2,4,5,6,7-hexahydro-4,7-methano-indazol-3-one (7), we optimized the potency and pharmacokinetic properties. This led to the identification of compounds with good in vivo activity in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a633bbb07d24cb3c7b6963f9c8c2b89d
https://doi.org/10.1016/j.bmcl.2014.04.049
https://doi.org/10.1016/j.bmcl.2014.04.049
Publikováno v:
MedChemComm. 7:1268-1270
Guest Editors Robert Goodnow and Christopher Davie recap the first Boston Symposium of Encoded Library Platforms and introduce the MedChemComm web collection on ‘DNA Encoded Libraries’.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84352da18aefe5451be1912652e8a733
https://doi.org/10.1039/c6md90023b
https://doi.org/10.1039/c6md90023b
Autor:
Andrew X. Zhang, Nicholas J. Pace, Michael Zinda, Alan Sabirsh, Aarti Kawatkar, James E. Dowling, Farzin Garahdaghi, Kumar Thakur, Timothy Pontz, Christopher R. Denz, Ivan Cornella-Taracido, Matias Casás-Selves, Qing Cao, Eranthie Weerapana, Robert A. Goodnow, Jun Hu, Nichole O'Connell, Stefan Hallén, M. Paola Castaldi
Publikováno v:
ChemMedChem. 12(12)
Wnt signaling is critical for development, cell proliferation and differentiation, and mutations in this pathway resulting in constitutive signaling have been implicated in various cancers. A pathway screen using a Wnt-dependent reporter identified a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fedc882f308f647e7c45cd0e5928963b
https://pubmed.ncbi.nlm.nih.gov/28371485
https://pubmed.ncbi.nlm.nih.gov/28371485
In the 25 years since the first publication of the concept of encoded combinatorial library synthesis with sequences of DNA, DNA-encoded library technology (DELT) has become a widely accepted method for hit finding along with high-throughput screenin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99ccc4ec92e09151516da9498802266b
https://doi.org/10.1016/bs.armc.2017.09.002
https://doi.org/10.1016/bs.armc.2017.09.002
Publikováno v:
Nature reviews. Drug discovery. 16(2)
DNA-encoded chemistry enables rapid and inexpensive syntheses and screening of vast chemical libraries, and is generating substantial interest and investment in the pharmaceutical industry. Here, Goodnow and colleagues provide an overview of the step
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25f945b0e111a59e56333741312ad13a
https://pubmed.ncbi.nlm.nih.gov/27932801
https://pubmed.ncbi.nlm.nih.gov/27932801