Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Robert A, Figler"'
Autor:
Ryan E Feaver, M Scott Bowers, Banumathi K Cole, Steve Hoang, Mark J Lawson, Justin Taylor, Brian D LaMoreaux, Lin Zhao, Brad R Henke, Brian A Johns, Andrew C Nyborg, Brian R Wamhoff, Robert A Figler
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0291330 (2023)
Some health concerns are often not identified until late into clinical development of drugs, which can place participants and patients at significant risk. For example, the United States Food and Drug Administration (FDA) labeled the xanthine oxidase
Externí odkaz:
https://doaj.org/article/73653be581c742099685677071b70e9b
Autor:
Devin G. Roller, Stephen A. Hoang, Kristopher D. Rawls, Katherine A. Owen, Michael B. Simmers, Robert A. Figler, Julia D. Wulfkuhle, Emanuel F. Petricoin, Brian R. Wamhoff, Daniel Gioeli
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Lung cancer rates are rising globally and non-small cell lung cancer (NSCLC) has a five year survival rate of only 24%. Unfortunately, the development of drugs to treat cancer is severely hampered by the inefficiency of translating pre-clini
Externí odkaz:
https://doaj.org/article/8c42edff85c244b88abc08fd238c4aa8
Autor:
Emma L. Shepherd, Raquel Saborano, Ellie Northall, Kae Matsuda, Hitomi Ogino, Hiroaki Yashiro, Jason Pickens, Ryan E. Feaver, Banumathi K. Cole, Stephen A. Hoang, Mark J. Lawson, Matthew Olson, Robert A. Figler, John E. Reardon, Nobuhiro Nishigaki, Brian R. Wamhoff, Ulrich L. Günther, Gideon Hirschfield, Derek M. Erion, Patricia F. Lalor
Publikováno v:
JHEP Reports, Vol 3, Iss 2, Pp 100217- (2021)
Background & Aims: Increasing evidence highlights dietary fructose as a major driver of non-alcoholic fatty liver disease (NAFLD) pathogenesis, the majority of which is cleared on first pass through the hepatic circulation by enzymatic phosphorylatio
Externí odkaz:
https://doaj.org/article/4340ddc01197436fbd613f61ff255144
Autor:
Maria S. Collado, Banumathi K. Cole, Robert A. Figler, Mark Lawson, David Manka, Michael B. Simmers, Steve Hoang, Felipe Serrano, Brett R. Blackman, Sanjay Sinha, Brian R. Wamhoff
Publikováno v:
Stem Cells Translational Medicine, Vol 6, Iss 8, Pp 1673-1683 (2017)
Abstract Human induced pluripotent stem cells (iPSCs) can be differentiated into vascular endothelial (iEC) and smooth muscle (iSMC) cells. However, because iECs and iSMCs are not derived from an intact blood vessel, they represent an immature phenot
Externí odkaz:
https://doaj.org/article/13ade552b30543e5bd3d6e5691a0dbeb
Autor:
Charles J. Billington, Kimberly A. Chapman, Eyby Leon, Beatrix W. Meltzer, Seth I. Berger, Matthew Olson, Robert A. Figler, Steve A. Hoang, Cui Wanxing, Brian R. Wamhoff, M. Sol Collado, Kristina Cusmano‐Ozog
Publikováno v:
American Journal of Medical Genetics Part A. 188:2738-2749
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b66d3c54f69fb3e39a611777e46bfaa
https://doi.org/10.1002/ajmg.a.62893
https://doi.org/10.1002/ajmg.a.62893
Autor:
Brian A. Johns, Christin A. Hamilton, Allison J. Armstrong, Robert A. Figler, Maria Sol Collado, Taylor D. Pourtaheri, Brad R. Henke, Marshall M. Summar, Stephen A. Hoang, Kimberly A. Chapman, John E. Reardon, Brian R. Wamhoff, Matthew W. Olson
Publikováno v:
Mol Genet Metab
Propionic Acidemia (PA) and Methylmalonic Acidemia (MMA) are inborn errors of metabolism affecting the catabolism of valine, isoleucine, methionine, threonine and odd-chain fatty acids. These are multi-organ disorders caused by the enzymatic deficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2d2bba59a2136c64aeca4cb4d67b68
https://doi.org/10.1016/j.ymgme.2021.03.001
https://doi.org/10.1016/j.ymgme.2021.03.001
Autor:
Brian R. Wamhoff, Daniel Gioeli, Devin G. Roller, Kristopher D. Rawls, Katherine A. Owen, Emanuel F. Petricoin, Julia Wulfkuhle, Stephen A. Hoang, Robert A. Figler, Michael B. Simmers
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Lung cancer rates are rising globally and non-small cell lung cancer (NSCLC) has a five year survival rate of only 24%. Unfortunately, the development of drugs to treat cancer is severely hampered by the inefficiency of translating pre-clinical studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b6fb5abd08967fc19b35686028bfdb
https://doaj.org/article/8c42edff85c244b88abc08fd238c4aa8
https://doaj.org/article/8c42edff85c244b88abc08fd238c4aa8
Autor:
Nathan Day, Brian R. Wamhoff, Matthew Olson, Marshall L. Summar, Allison J. Armstrong, Stephen A. Hoang, Robert A. Figler, M. Sol Collado, John E. Reardon, Kimberly A. Chapman
Publikováno v:
Mol Genet Metab
Propionic acidemia (PA) and methylmalonic acidemia (MMA) are autosomal recessive disorders of propionyl-CoA (P-CoA) catabolism, which are caused by a deficiency in the enzyme propionyl-CoA carboxylase or the enzyme methylmalonyl-CoA (MM-CoA) mutase,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa105949df1c68bac4254f95a16f56af
https://doi.org/10.1016/j.ymgme.2020.05.003
https://doi.org/10.1016/j.ymgme.2020.05.003
Autor:
John E Dillberger, Thomas D Roper, Allison J. Armstrong, Brian R. Wamhoff, Stephen A. Hoang, Matthew W. Olson, Justin M. Taylor, Brad R. Henke, John E. Reardon, Maria Sol Collado, Brian A. Johns, Robert A. Figler, Taylor D. Pourtaheri
Publikováno v:
Journal of medicinal chemistry. 64(8)
Propionic acidemia (PA) and methylmalonic acidemia (MMA) are rare autosomal recessive disorders of propionyl-CoA (P-CoA) catabolism, caused by a deficiency in the enzymes P-CoA carboxylase and methylmalonyl-CoA (M-CoA) mutase, respectively. PA and MM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254da545beecc6f429bfbe4bad4afc4f
https://pubmed.ncbi.nlm.nih.gov/33848153
https://pubmed.ncbi.nlm.nih.gov/33848153
Autor:
Ellie Northall, Banumathi K. Cole, John E. Reardon, Brian R. Wamhoff, Matthew W. Olson, Stephen A. Hoang, Kae Matsuda, Ulrich L. Günther, Mark J. Lawson, Ryan E. Feaver, Jason Pickens, Patricia F. Lalor, Raquel Saborano, Robert A. Figler, Hiroaki Yashiro, Derek M. Erion, Hitomi Ogino, Emma L. Shepherd, Gideon M. Hirschfield, Nobuhiro Nishigaki
Publikováno v:
JHEP Reports, Vol 3, Iss 2, Pp 100217-(2021)
JHEP Reports
JHEP Reports
Background & Aims Increasing evidence highlights dietary fructose as a major driver of non-alcoholic fatty liver disease (NAFLD) pathogenesis, the majority of which is cleared on first pass through the hepatic circulation by enzymatic phosphorylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e901d5e74295d49cc1586ef5be254e
http://www.sciencedirect.com/science/article/pii/S2589555920301518
http://www.sciencedirect.com/science/article/pii/S2589555920301518