Zobrazeno 1 - 10
of 491
pro vyhledávání: '"Robert A, Batey"'
Autor:
Corentin Bedart, Grace Shimokura, Frederick G. West, Tabitha E. Wood, Robert A. Batey, John J. Irwin, Matthieu Schapira
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-13 (2024)
Abstract Computationally screening chemical libraries to discover molecules with desired properties is a common technique used in early-stage drug discovery. Recent progress in the field now enables the efficient exploration of billions of molecules
Externí odkaz:
https://doaj.org/article/b624ee73a7a94805b65486ee4eb98585
Publikováno v:
BMC Research Notes, Vol 16, Iss 1, Pp 1-4 (2023)
Abstract Objectives The glucocorticoid receptor (GR) is a well-studied, ligand-activated transcription factor and a common target of anti-inflammatory treatments. Recently, several studies have drawn attention the effects of binding of GR to RNA rath
Externí odkaz:
https://doaj.org/article/e19431f23b724374b3466764dc2229f5
Autor:
Nickolaus C. Lammer, Humza M. Ashraf, Daniella A. Ugay, Sabrina L. Spencer, Mary A. Allen, Robert T. Batey, Deborah S. Wuttke
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The glucocorticoid receptor (GR) is a ligand-activated transcription factor that regulates a suite of genes through direct binding of GR to specific DNA promoter elements. GR also interacts with RNA, but the function of this RNA-binding acti
Externí odkaz:
https://doaj.org/article/5fd3b59696db4521b28300ffa680c084
Autor:
Zachariah E. Holmes, Desmond J. Hamilton, Taeyoung Hwang, Nicholas V. Parsonnet, John L. Rinn, Deborah S. Wuttke, Robert T. Batey
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Some transcription factors have been proposed to functionally interact with RNA to facilitate proper regulation of gene expression. Here the authors demonstrate that human Sox2 interact directly and with high affinity to RNAs through its HMG DNA-bind
Externí odkaz:
https://doaj.org/article/b2a71949f809466bb1ecf7371b1026f2
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Bacteria lack the same suite of CRISPR tools that have been developed for mammalian cells. Here, the authors link aptamers to sgRNAs to allow small molecule control of gene editing in E. coli.
Externí odkaz:
https://doaj.org/article/ded3f93171cd4f4bb57d5a441ed60ade
Autor:
Shelby R. Lennon, Aleksandra J. Wierzba, Shea H. Siwik, Dorota Gryko, Amy E. Palmer, Robert T. Batey
Publikováno v:
ACS Chemical Biology. 18:1136-1147
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2342316c381c8a6734920f6323ae7d60
https://doi.org/10.1021/acschembio.2c00939
https://doi.org/10.1021/acschembio.2c00939
Autor:
Mikhail Ignatov, Akhil Jindal, Sergei Kotelnikov, Dmitri Beglov, Ganna Posternak, Xiaojing Tang, Pierre Maisonneuve, Gennady Poda, Robert A. Batey, Frank Sicheri, Adrian Whitty, Peter J. Tonge, Sandor Vajda, Dima Kozakov
Publikováno v:
Journal of the American Chemical Society. 145:7123-7135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::510d834b0d63ea62c192849afd677972
https://doi.org/10.1021/jacs.2c09387
https://doi.org/10.1021/jacs.2c09387
Autor:
Ava C Carter, Jin Xu, Meagan Y Nakamoto, Yuning Wei, Brian J Zarnegar, Quanming Shi, James P Broughton, Ryan C Ransom, Ankit Salhotra, Surya D Nagaraja, Rui Li, Diana R Dou, Kathryn E Yost, Seung-Woo Cho, Anil Mistry, Michael T Longaker, Paul A Khavari, Robert T Batey, Deborah S Wuttke, Howard Y Chang
Publikováno v:
eLife, Vol 9 (2020)
The Xist lncRNA mediates X chromosome inactivation (XCI). Here we show that Spen, an Xist-binding repressor protein essential for XCI , binds to ancient retroviral RNA, performing a surveillance role to recruit chromatin silencing machinery to these
Externí odkaz:
https://doaj.org/article/4ae4315c8e724765a92613e02ab27e83
Autor:
Lea K Drogalis, Robert T Batey
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243155 (2020)
Riboswitches, generally located in the 5'-leader of bacterial mRNAs, direct expression via a small molecule-dependent structural switch that informs the transcriptional or translational machinery. While the structure and function of riboswitch effect
Externí odkaz:
https://doaj.org/article/f711c32adf574f12b70b26c9a1ed00ce
Publikováno v:
Biochemistry. 61:2490-2494
Estrogen receptor alpha (ERα) is a ligand-responsive transcription factor critical for sex determination and development. Recent reports challenge the canonical view of ERα function by suggesting an activity beyond binding dsDNA at estrogen-respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e45dd5f02cb05c4354825fbc1a809a3
https://doi.org/10.1021/acs.biochem.2c00536
https://doi.org/10.1021/acs.biochem.2c00536