Zobrazeno 1 - 10
of 229
pro vyhledávání: '"Robert V. Stahelin"'
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 11, Pp 100663- (2024)
Plasma membrane (PM) domains and order phases have been shown to play a key role in the assembly, release, and entry of several lipid-enveloped viruses. In the present study, we provide a mechanistic understanding of the Ebola virus (EBOV) matrix pro
Externí odkaz:
https://doaj.org/article/4e984c7d200344eaad048843b83c8e07
Impact of Ebola virus nucleoprotein on VP40 virus-like particle production: a computational approach
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Ebola virus (EBOV) matrix protein VP40 can assemble and bud as virus-like particles (VLPs) when expressed alone in mammalian cells. Nucleoprotein (NP) could be recruited to VLPs as inclusion body (IB) when co-expressed, and increase VLP prod
Externí odkaz:
https://doaj.org/article/93a391c333704612b2a474633f4a37b4
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 4 (2024)
ABSTRACTEbola virus (EBOV) infection is threatening human health, especially in Central and West Africa. Limited clinical trials and the requirement of biosafety level-4 laboratories hinder experimental work to advance our understanding of EBOV and t
Externí odkaz:
https://doaj.org/article/3bc91e9432db4f21be1a667bd41a2506
Autor:
Kristen A. Johnson, Melissa R. Budicini, Nisha Bhattarai, Tej Sharma, Sarah Urata, Bernard S. Gerstman, Prem P. Chapagain, Sheng Li, Robert V. Stahelin
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 3, Pp 100512- (2024)
Ebola virus (EBOV) causes severe hemorrhagic fever in humans and is lethal in a large percentage of those infected. The EBOV matrix protein viral protein 40 kDa (VP40) is a peripheral binding protein that forms a shell beneath the lipid bilayer in vi
Externí odkaz:
https://doaj.org/article/8a3341cab06f4c60a01e5ef7dbe9ff15
Autor:
Angana Mukherjee, Marie-Ève Crochetière, Audrey Sergerie, Souad Amiar, L. Alexa Thompson, Zeinab Ebrahimzadeh, Dominic Gagnon, Florian Lauruol, Alexandra Bourgeois, Thomas Galaup, Stéphanie Roucheray, Stéphanie Hallée, Prasad K. Padmanabhan, Robert V. Stahelin, Joel B. Dacks, Dave Richard
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Phosphoinositide lipids play key roles in a variety of processes in eukaryotic cells, but our understanding of their functions in the malaria parasite Plasmodium falciparum is still very much limited. To gain a deeper comprehension of the ro
Externí odkaz:
https://doaj.org/article/9e43f0123320471f913225822f115263
Autor:
Silvia Vaena, Paramita Chakraborty, Han Gyul Lee, Alhaji H. Janneh, Mohamed Faisal Kassir, Gyda Beeson, Zachariah Hedley, Ahmet Yalcinkaya, M. Hanief Sofi, Hong Li, Monica L. Husby, Robert V. Stahelin, Xue-Zhong Yu, Shikhar Mehrotra, Besim Ogretmen
Publikováno v:
Cell Reports, Vol 35, Iss 5, Pp 109076- (2021)
Summary: We lack a mechanistic understanding of aging-mediated changes in mitochondrial bioenergetics and lipid metabolism that affect T cell function. The bioactive sphingolipid ceramide, induced by aging stress, mediates mitophagy and cell death; h
Externí odkaz:
https://doaj.org/article/1e9021872d124ee9993e5c571f0785f7
Autor:
Larissa Smulders, Rachel Altman, Carolina Briseno, Alireza Saatchi, Leslie Wallace, Maha AlSebaye, Robert V. Stahelin, Nikolas Nikolaidis
Publikováno v:
Biomolecules, Vol 12, Iss 6, p 856 (2022)
HSPA1A is a molecular chaperone that regulates the survival of stressed and cancer cells. In addition to its cytosolic pro-survival functions, HSPA1A also localizes and embeds in the plasma membrane (PM) of stressed and tumor cells. Membrane-associat
Externí odkaz:
https://doaj.org/article/3a3c3e43df4f43ed8bd05905939198aa
Autor:
Balindile B. Motsa, Robert V. Stahelin
Publikováno v:
The Biochemist. 45:18-22
Surface plasmon resonance (SPR) has emerged as a powerful optical detection technique for studying the binding behaviour of immobilized ligands and analytes in solution. The technique makes it possible to measure interactions in real time with high s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d0d517042a9adb25e1a2159027b9152
https://doi.org/10.1042/bio_2022_139
https://doi.org/10.1042/bio_2022_139
Autor:
Amar Parvate, Ranjan Sengupta, Evan P. Williams, Yi Xue, Yong-Kyu Chu, Robert V. Stahelin, Colleen B. Jonsson
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Hantaviruses rewire the host cell and induce extensive membrane rearrangements for their replication and the morphogenesis of the virion. Transmission electron microscopy (TEM) is a powerful technique for imaging these pathological membrane changes e
Externí odkaz:
https://doaj.org/article/a8fa4aa1a6794a79a75c0dc9be9fcf43
Autor:
Souad Amiar, Robert V. Stahelin
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 7, Pp 971- (2020)
Externí odkaz:
https://doaj.org/article/0ce6d69e258648599609e88323719dc7